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Slc36a4 solute carrier family 36 (proton/amino acid symporter), member 4 [ Mus musculus (house mouse) ]

Gene ID: 234967, updated on 4-Jan-2025

Summary

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Official Symbol
Slc36a4provided by MGI
Official Full Name
solute carrier family 36 (proton/amino acid symporter), member 4provided by MGI
Primary source
MGI:MGI:2442595
See related
Ensembl:ENSMUSG00000043885 AllianceGenome:MGI:2442595
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
PAT4; 6330573I15Rik
Summary
Predicted to enable L-alanine transmembrane transporter activity; L-proline transmembrane transporter activity; and L-tryptophan transmembrane transporter activity. Predicted to be involved in amino acid transmembrane transport and carboxylic acid transport. Located in lysosomal membrane. Orthologous to human SLC36A4 (solute carrier family 36 member 4). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Broad expression in CNS E18 (RPKM 9.5), whole brain E14.5 (RPKM 7.8) and 26 other tissues See more
Orthologs
human all
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Genomic context

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See Slc36a4 in Genome Data Viewer
Location:
9 A2; 9 5.12 cM
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (15621034..15653684)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (15709738..15742388)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 35225 Neighboring gene high mobility group box 2 pseudogene Neighboring gene STARR-seq mESC enhancer starr_23387 Neighboring gene melatonin receptor 1B Neighboring gene FAT atypical cadherin 3 Neighboring gene STARR-seq mESC enhancer starr_23388 Neighboring gene STARR-seq mESC enhancer starr_23389 Neighboring gene STARR-seq mESC enhancer starr_23390 Neighboring gene STARR-seq mESC enhancer starr_23391 Neighboring gene STARR-seq mESC enhancer starr_23392 Neighboring gene STARR-seq mESC enhancer starr_23393 Neighboring gene predicted gene, 53499

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. PAT4 is abundantly expressed in excitatory and inhibitory neurons as well as epithelial cells. Roshanbin S, et al. Brain Res, 2014 Apr 4. PMID 24530433
  2. The amino acid transporter SLC36A4 regulates the amino acid pool in retinal pigmented epithelial cells and mediates the mechanistic target of rapamycin, complex 1 signaling. Shang P, et al. Aging Cell, 2017 Apr. PMID 28083894, Free PMC Article
  3. Rab12 regulates mTORC1 activity and autophagy through controlling the degradation of amino-acid transporter PAT4. Matsui T, et al. EMBO Rep, 2013 May. PMID 23478338, Free PMC Article
  4. Tpbpa-Cre-mediated deletion of TFAP2C leads to deregulation of Cdkn1a, Akt1 and the ERK pathway, causing placental growth arrest. Sharma N, et al. Development, 2016 Mar 1. PMID 26811378
  5. GenePaint.org: an atlas of gene expression patterns in the mouse embryo. Visel A, et al. Nucleic Acids Res, 2004 Jan 1. PMID 14681479, Free PMC Article

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. the amino acid transporter SLC36A4/proton-dependent amino acid transporter (PAT4) regulates the amino acid pool in the lysosomes of retinal pigment epithelium.
    Title: The amino acid transporter SLC36A4 regulates the amino acid pool in retinal pigmented epithelial cells and mediates the mechanistic target of rapamycin, complex 1 signaling.
  2. Detailed analysis of Slc36a4 mRNA distribution and protein mapping in mouse brain, showing an abundant expression in piriform cortex, hippocampus and hypothalamus in inhibitory and excitatory neurons and epithelial cells lining the ventricles in the brain
    Title: PAT4 is abundantly expressed in excitatory and inhibitory neurons as well as epithelial cells.
  3. A new mechanism of regulation of mTORC1 signalling and autophagy, that is, quality control of PAT4 by Rab12.
    Title: Rab12 regulates mTORC1 activity and autophagy through controlling the degradation of amino-acid transporter PAT4.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables L-alanine transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables L-alanine transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
  
enables L-proline transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables L-proline transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
  
enables L-tryptophan transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
  
enables symporter activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in L-alanine transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in L-alanine transport ISO
Inferred from Sequence Orthology
more info
  
involved_in L-alanine transport ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in amino acid transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in proline transport ISO
Inferred from Sequence Orthology
more info
  
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in tryptophan transport ISO
Inferred from Sequence Orthology
more info
  
involved_in tryptophan transport ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in lysosomal membrane IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in vacuolar membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
neutral amino acid uniporter 4
Names
proton-coupled amino acid transporter 4
proton/amino acid transporter 4
solute carrier family 36 member 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001357565.1 → NP_001344494.1  neutral amino acid uniporter 4 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice junction in the 3' coding sequence compared to variant 1, that causes a frameshift. The resulting isoform (2) has a shorter and distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AC154307, AK150167
    Consensus CDS
    CCDS90503.1
    UniProtKB/TrEMBL
    D3Z0L1
    Related
    ENSMUSP00000111251.2, ENSMUST00000115588.8
    Conserved Domains (1) summary
    cl00456
    Location:54 → 397
    SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain

  2. NM_001357566.1 → NP_001344495.1  neutral amino acid uniporter 4 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (3) is shorter at the N-terminus compared to isoform 1.
    Source sequence(s)
    AC154307
    Conserved Domains (1) summary
    cl00456
    Location:15 → 337
    SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain

  3. NM_001357567.1 → NP_001344496.1  neutral amino acid uniporter 4 isoform 4

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR and coding sequence and uses an alternate in-frame splice junction in the 3' coding sequence compared to variant 1, that causes a frameshift. The resulting isoform (4) is shorter at the N-terminus and has a shorter and distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AC154307
    Conserved Domains (1) summary
    cl00456
    Location:15 → 265
    SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain

  4. NM_172289.5 → NP_758493.2  neutral amino acid uniporter 4 isoform 1

    See identical proteins and their annotated locations for NP_758493.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AC154307, AK032074
    Consensus CDS
    CCDS22840.1
    UniProtKB/Swiss-Prot
    Q8C077, Q8CH36
    UniProtKB/TrEMBL
    A0A0R4J0Q3
    Related
    ENSMUSP00000057355.8, ENSMUST00000061568.9
    Conserved Domains (1) summary
    cl00456
    Location:54 → 469
    SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    15621034..15653684
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030244281.2 → XP_030100141.1  neutral amino acid uniporter 4 isoform X2

    Conserved Domains (1) summary
    cl00456
    Location:15 → 337
    SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain

  2. XM_006510170.5 → XP_006510233.1  neutral amino acid uniporter 4 isoform X1

    UniProtKB/Swiss-Prot
    Q8C077, Q8CH36
    Conserved Domains (1) summary
    cl00456
    Location:38 → 453
    SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8CH36.1 GenPept UniProtKB/Swiss-Prot:Q8CH36

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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