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Ddx49 DEAD box helicase 49 [ Mus musculus (house mouse) ]

Gene ID: 234374, updated on 4-Jan-2025

Summary

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Official Symbol
Ddx49provided by MGI
Official Full Name
DEAD box helicase 49provided by MGI
Primary source
MGI:MGI:2136689
See related
Ensembl:ENSMUSG00000057788 AllianceGenome:MGI:2136689
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
R27090_2
Summary
Predicted to enable several functions, including ATP binding activity; ATP hydrolysis activity; and ATP-dependent activity, acting on DNA. Predicted to be involved in positive regulation of cell growth; rRNA processing; and regulation of rRNA stability. Predicted to be active in nucleus. Orthologous to human DDX49 (DEAD-box helicase 49). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Ubiquitous expression in ovary adult (RPKM 41.1), cerebellum adult (RPKM 36.1) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Ddx49 in Genome Data Viewer
Location:
8 B3.3; 8 34.15 cM
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (70745516..70755121, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (70292866..70302471, complement)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene armadillo repeat containing 6 Neighboring gene STARR-positive B cell enhancer ABC_E8239 Neighboring gene SURP and G patch domain containing 2 Neighboring gene predicted gene, 38427 Neighboring gene homer scaffolding protein 3 Neighboring gene STARR-positive B cell enhancer ABC_E8240 Neighboring gene coatomer protein complex, subunit epsilon Neighboring gene ceramide synthase 1 Neighboring gene growth differentiation factor 1 Neighboring gene UPF1 RNA helicase and ATPase

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Comparative analysis of human 19p12-13 region in Fugu and mouse. Clarke D, et al. Mamm Genome, 2001 Jun. PMID 11353399
  2. Transcription factor Foxp3 and its protein partners form a complex regulatory network. Rudra D, et al. Nat Immunol, 2012 Oct. PMID 22922362, Free PMC Article
  3. Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method. Piao Y, et al. Genome Res, 2001 Sep. PMID 11544199, Free PMC Article
  4. Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas. Watahiki A, et al. Nat Methods, 2004 Dec. PMID 15782199
  5. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Gene trapped (1) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
  
enables ATP-dependent H2AZ histone chaperone activity IEA
Inferred from Electronic Annotation
more info
  
enables ATP-dependent H3-H4 histone complex chaperone activity IEA
Inferred from Electronic Annotation
more info
  
enables DNA clamp loader activity IEA
Inferred from Electronic Annotation
more info
  
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables RNA helicase activity IEA
Inferred from Electronic Annotation
more info
  
enables chromatin extrusion motor activity IEA
Inferred from Electronic Annotation
more info
  
enables cohesin loader activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in chromatin looping IEA
Inferred from Electronic Annotation
more info
  
involved_in chromatin remodeling IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of cell growth IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of cell growth ISO
Inferred from Sequence Orthology
more info
  
involved_in rRNA processing IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of rRNA stability IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of rRNA stability ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
probable ATP-dependent RNA helicase DDX49
Names
DEAD (Asp-Glu-Ala-Asp) box polypeptide 49
DEAD (aspartate-glutamate-alanine-aspartate) box polypeptide 27
DEAD box protein 49
DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 49
NP_001020093.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001024922.2 → NP_001020093.2  probable ATP-dependent RNA helicase DDX49

    See identical proteins and their annotated locations for NP_001020093.2

    Status: VALIDATED

    Source sequence(s)
    AA544796, BC085301
    Consensus CDS
    CCDS22364.1
    UniProtKB/Swiss-Prot
    Q4FZF3
    Related
    ENSMUSP00000008004.10, ENSMUST00000008004.10
    Conserved Domains (4) summary
    PRK11192
    Location:4 → 459
    PRK11192; ATP-dependent RNA helicase SrmB; Provisional
    cd00079
    Location:218 → 351
    HELICc; Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may ...
    cd00268
    Location:4 → 206
    DEADc; DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif ...
    cl19511
    Location:363 → 454
    DUF2317; Uncharacterized protein conserved in bacteria (DUF2317)

RNA

  1. NR_157058.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AA544796, BB578972, BC085301
    Related
    ENSMUST00000144890.8

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    70745516..70755121 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q4FZF3.1 GenPept UniProtKB/Swiss-Prot:Q4FZF3

Gene LinkOut

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