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U2SURP U2 snRNP associated SURP domain containing [ Homo sapiens (human) ]

Gene ID: 23350, updated on 27-Nov-2024

Summary

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Official Symbol
U2SURPprovided by HGNC
Official Full Name
U2 snRNP associated SURP domain containingprovided by HGNC
Primary source
HGNC:HGNC:30855
See related
Ensembl:ENSG00000163714 MIM:617849; AllianceGenome:HGNC:30855
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SR140; fSAPa
Summary
Enables RNA binding activity. Predicted to be involved in RNA processing. Located in nucleoplasm. [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in bone marrow (RPKM 18.6), lymph node (RPKM 15.0) and 25 other tissues See more
Orthologs
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Genomic context

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See U2SURP in Genome Data Viewer
Location:
3q23
Exon count:
29
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (143001570..143060725)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (145748812..145808123)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (142720412..142779567)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr3:142677150-142678349 Neighboring gene ReSE screen-validated silencer GRCh37_chr3:142681545-142681730 Neighboring gene progestin and adipoQ receptor family member 9 Neighboring gene PAQR9 antisense RNA 1 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:142717850-142718850 Neighboring gene uncharacterized LOC100289361 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:142719850-142720849 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20647 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr3:142791070-142791852 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr3:142792635-142793416 Neighboring gene uncharacterized LOC105374138 Neighboring gene CRISPRi-validated cis-regulatory element chr3.4297 Neighboring gene H3K27ac hESC enhancer GRCh37_chr3:142837669-142838170 Neighboring gene H3K27ac hESC enhancer GRCh37_chr3:142838171-142838670 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20650 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14793 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14794 Neighboring gene H3K27ac hESC enhancer GRCh37_chr3:142839329-142839970 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:142840613-142841254 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20651 Neighboring gene carbohydrate sulfotransferase 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. U2-related proteins CHERP and SR140 contribute to colorectal tumorigenesis via alternative splicing regulation. Wang Q, et al. Int J Cancer, 2019 Nov 15. PMID 30977118
  2. MYC-driven U2SURP regulates alternative splicing of SAT1 to promote triple-negative breast cancer progression. Deng L, et al. Cancer Lett, 2023 Apr 28. PMID 36907504
  3. Interactions of ErbB4 and Kap1 connect the growth factor and DNA damage response pathways. Gilmore-Hebert M, et al. Mol Cancer Res, 2010 Oct. PMID 20858735, Free PMC Article
  4. LncRNA H19 Regulates Breast Cancer DNA Damage Response and Sensitivity to PARP Inhibitors via Binding to ILF2. Zhao J, et al. Int J Mol Sci, 2023 May 23. PMID 37298108, Free PMC Article
  5. Mitochondrial antiviral-signalling protein is a client of the BAG6 protein quality control complex. Roboti P, et al. J Cell Sci, 2022 May 1. PMID 35543156, Free PMC Article

See all (155) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Protein interactions

Protein Gene Interaction Pubs
Tat tat Expression of HIV-1 Tat upregulates the abundance of U2 snRNP-associated SURP domain containing (U2SURP) in the nucleoli of Jurkat T-cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • KIAA0332, MGC133197

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables RNA binding HDA PubMed 
enables RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in RNA processing IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of U2 snRNP IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
  
located_in nucleoplasm TAS
Traceable Author Statement
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
U2 snRNP-associated SURP motif-containing protein
Names
140 kDa Ser/Arg-rich domain protein
Ser/Arg-rich domain protein, 140 kDa
U2-associated SR140 protein
U2-associated protein SR140
functional spliceosome-associated protein a

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001080415.2 → NP_001073884.1  U2 snRNP-associated SURP motif-containing protein isoform 1

    See identical proteins and their annotated locations for NP_001073884.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AC018450, AC026304
    Consensus CDS
    CCDS46928.1
    UniProtKB/Swiss-Prot
    A0PJ60, O15042, Q0D2M1, Q2NKQ7, Q9BR70
    Related
    ENSP00000418563.1, ENST00000473835.7
    Conserved Domains (5) summary
    smart00582
    Location:541 → 676
    RPR; domain present in proteins, which are involved in regulation of nuclear pre-mRNA
    COG0724
    Location:156 → 352
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
    pfam01805
    Location:429 → 480
    Surp; Surp module
    cd12223
    Location:273 → 356
    RRM_SR140; RNA recognition motif (RRM) found in U2-associated protein SR140 and similar proteins
    cd21370
    Location:836 → 884
    cwf21_SR140; cwf21 domain found in U2-associated protein SR140 and similar proteins

  2. NM_001320219.2 → NP_001307148.1  U2 snRNP-associated SURP motif-containing protein isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice junction compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is 1 aa shorter compared to isoform 1.
    Source sequence(s)
    AC018450, BC006474, BC111692
    UniProtKB/Swiss-Prot
    O15042
    Related
    ENSP00000422011.1, ENST00000493598.6
    Conserved Domains (5) summary
    smart00582
    Location:540 → 675
    RPR; domain present in proteins, which are involved in regulation of nuclear pre-mRNA
    COG0724
    Location:156 → 351
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
    pfam01805
    Location:428 → 479
    Surp; Surp module
    cd12223
    Location:272 → 355
    RRM_SR140; RNA recognition motif (RRM) found in U2-associated protein SR140 and similar proteins
    cd21370
    Location:835 → 883
    cwf21_SR140; cwf21 domain found in U2-associated protein SR140 and similar proteins

  3. NM_001320220.2 → NP_001307149.1  U2 snRNP-associated SURP motif-containing protein isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) contains an alternate exon compared to variant 1. The resulting isoform (3) has a shorter and distinct N-terminus compared to isoform 1.
    Source sequence(s)
    AC018450, BC111692
    UniProtKB/Swiss-Prot
    O15042
    Conserved Domains (3) summary
    smart00582
    Location:132 → 267
    RPR; domain present in proteins, which are involved in regulation of nuclear pre-mRNA
    pfam01805
    Location:20 → 71
    Surp; Surp module
    cd21370
    Location:427 → 475
    cwf21_SR140; cwf21 domain found in U2-associated protein SR140 and similar proteins

  4. NM_001320222.2 → NP_001307151.1  U2 snRNP-associated SURP motif-containing protein isoform 4

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) contains an alternate exon compared to variant 1. The resulting isoform (4) is shorter at the N-terminus compared to isoform 1.
    Source sequence(s)
    AC018450, BC028110, BC111692
    UniProtKB/Swiss-Prot
    O15042
    Conserved Domains (3) summary
    smart00582
    Location:108 → 243
    RPR; domain present in proteins, which are involved in regulation of nuclear pre-mRNA
    pfam01805
    Location:1 → 47
    Surp; Surp module
    pfam08312
    Location:410 → 451
    cwf21; cwf21 domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

    Range
    143001570..143060725
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060927.1 Alternate T2T-CHM13v2.0

    Range
    145748812..145808123
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O15042.2 GenPept UniProtKB/Swiss-Prot:O15042

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