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Prc1 protein regulator of cytokinesis 1 [ Mus musculus (house mouse) ]

Gene ID: 233406, updated on 27-Nov-2024

Summary

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Official Symbol
Prc1provided by MGI
Official Full Name
protein regulator of cytokinesis 1provided by MGI
Primary source
MGI:MGI:1858961
See related
Ensembl:ENSMUSG00000038943 AllianceGenome:MGI:1858961
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
D7Ertd348e
Summary
Predicted to enable cytoskeletal protein binding activity; identical protein binding activity; and protein kinase binding activity. Predicted to be involved in mitotic spindle midzone assembly; positive regulation of cell population proliferation; and regulation of cytokinesis. Predicted to act upstream of or within microtubule bundle formation. Predicted to be located in several cellular components, including contractile ring; intercellular bridge; and midbody. Predicted to be active in cytoplasm and mitotic spindle midzone. Is expressed in several structures, including alimentary system; genitourinary system; heart; nervous system; and sensory organ. Orthologous to human PRC1 (protein regulator of cytokinesis 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Broad expression in CNS E11.5 (RPKM 31.2), liver E14 (RPKM 29.8) and 16 other tissues See more
Orthologs
human all
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Genomic context

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See Prc1 in Genome Data Viewer
Location:
7 D2; 7 45.62 cM
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (79944224..79966007)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (80294445..80316259)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E2826 Neighboring gene neugrin, neurite outgrowth associated Neighboring gene vacuolar protein sorting 33B Neighboring gene STARR-positive B cell enhancer ABC_E2827 Neighboring gene RCC1 domain containing 1 Neighboring gene unc-45 myosin chaperone A Neighboring gene STARR-positive B cell enhancer ABC_E2828 Neighboring gene STARR-positive B cell enhancer ABC_E6566 Neighboring gene HD domain containing 3 Neighboring gene high mobility group box 2 pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Dual role of Med12 in PRC1-dependent gene repression and ncRNA-mediated transcriptional activation. Papadopoulou T, et al. Cell Cycle, 2016 Jun 2. PMID 27096886, Free PMC Article
  2. Live-cell single-molecule tracking reveals co-recognition of H3K27me3 and DNA targets polycomb Cbx7-PRC1 to chromatin. Zhen CY, et al. Elife, 2016 Oct 10. PMID 27723458, Free PMC Article
  3. Cdk1 negatively regulates the spindle localization of Prc1 in mouse oocytes. Nishiyama S, et al. Genes Cells, 2020 Oct. PMID 32865279
  4. PRC1 is a critical regulator for anaphase spindle midzone assembly and cytokinesis in mouse oocyte meiosis. Li XH, et al. FEBS J, 2021 May. PMID 33206458
  5. RYBP/YAF2-PRC1 complexes and histone H1-dependent chromatin compaction mediate propagation of H2AK119ub1 during cell division. Zhao J, et al. Nat Cell Biol, 2020 Apr. PMID 32203418

See all (52) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Polycomb repressive complexes 1 and 2 are each essential for maintenance of X inactivation in extra-embryonic lineages.
    Title: Polycomb repressive complexes 1 and 2 are each essential for maintenance of X inactivation in extra-embryonic lineages.
  2. PRC1 is a critical regulator for anaphase spindle midzone assembly and cytokinesis in mouse oocyte meiosis.
    Title: PRC1 is a critical regulator for anaphase spindle midzone assembly and cytokinesis in mouse oocyte meiosis.
  3. Cdk1 negatively regulates the spindle localization of Prc1 in mouse oocytes.
    Title: Cdk1 negatively regulates the spindle localization of Prc1 in mouse oocytes.
  4. Prc1-rich kinetochores are required for error-free acentrosomal spindle bipolarization during meiosis I in mouse oocytes.
    Title: Prc1-rich kinetochores are required for error-free acentrosomal spindle bipolarization during meiosis I in mouse oocytes.
  5. The results suggest that histone H1-dependent chromatin compaction plays a critical role in the stable propagation of H2AK119ub1 by RYBP/YAF2-PRC1 during cell division.
    Title: RYBP/YAF2-PRC1 complexes and histone H1-dependent chromatin compaction mediate propagation of H2AK119ub1 during cell division.
  6. Results indicate that Ub-independent mode of repression by PRC1 plays a key role in mammalian development during cell fate restriction.
    Title: Ubiquitination-Independent Repression of PRC1 Targets during Neuronal Fate Restriction in the Developing Mouse Neocortex.
  7. Authors analyzed whether elevated levels of the polycomb repressor complex 1 (PRC1) components Bmi1 and Ring1b and their catalyzed histone modification H2AK119ub in ADMs and tumor cells, are responsible for the mediation of acinar gene silencing.
    Title: Polycomb repressor complex 1 promotes gene silencing through H2AK119 mono-ubiquitination in acinar-to-ductal metaplasia and pancreatic cancer cells.
  8. Here, the authors discover that the histone H2AK119 E3 ubiquitin ligase activity of Polycomb repressive complex 1 (PRC1) is defined by the composition of its catalytic subunits and is highly regulated by RYBP/YAF2-dependent stimulation.
    Title: RYBP stimulates PRC1 to shape chromatin-based communication between Polycomb repressive complexes.
  9. Here, by combining live-cell single-molecule tracking (SMT) and genetic engineering, the authors reveal that H3K27me3 contributes significantly to the targeting of Cbx7-PRC1 complex to chromatin.
    Title: Live-cell single-molecule tracking reveals co-recognition of H3K27me3 and DNA targets polycomb Cbx7-PRC1 to chromatin.
  10. Pcgf6 is essential for recruitment of PRC1.6 to chromatin. Our results reveal a previously uncharacterized, H2AK119ub1-independent chromatin assembly associated with PRC1.6 complex
    Title: Essential Role for Polycomb Group Protein Pcgf6 in Embryonic Stem Cell Maintenance and a Noncanonical Polycomb Repressive Complex 1 (PRC1) Integrity.
Submit: New GeneRIF Correction See all GeneRIFs (12)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Chemically induced (ENU) (1) 
  • Endonuclease-mediated (2) 
  • Targeted (2) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC6745

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables kinesin binding ISO
Inferred from Sequence Orthology
more info
  
enables microtubule binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables microtubule binding IEA
Inferred from Electronic Annotation
more info
  
enables protein kinase binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in cell division IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within cytokinesis ISO
Inferred from Sequence Orthology
more info
 PubMed 
acts_upstream_of_or_within microtubule bundle formation ISO
Inferred from Sequence Orthology
more info
 PubMed 
involved_in microtubule cytoskeleton organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitotic spindle midzone assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of cell population proliferation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of cytokinesis ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of cytokinesis ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in contractile ring ISO
Inferred from Sequence Orthology
more info
  
located_in contractile ring ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in intercellular bridge ISO
Inferred from Sequence Orthology
more info
  
located_in microtubule IEA
Inferred from Electronic Annotation
more info
  
located_in microtubule cytoskeleton ISO
Inferred from Sequence Orthology
more info
  
located_in midbody ISO
Inferred from Sequence Orthology
more info
  
located_in midbody ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in mitotic spindle midzone IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
is_active_in spindle IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in spindle ISO
Inferred from Sequence Orthology
more info
 PubMed 
located_in spindle ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in spindle pole IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
protein regulator of cytokinesis 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001285997.2 → NP_001272926.1  protein regulator of cytokinesis 1 isoform 2

    See identical proteins and their annotated locations for NP_001272926.1

    Status: VALIDATED

    Source sequence(s)
    AC109232, AC136740
    Consensus CDS
    CCDS71985.1
    UniProtKB/Swiss-Prot
    E9QPF0, Q8CE25, Q99K43
    UniProtKB/TrEMBL
    G3XA79
    Related
    ENSMUSP00000043379.8, ENSMUST00000047558.14
    Conserved Domains (2) summary
    pfam03999
    Location:37 → 598
    MAP65_ASE1; Microtubule associated protein (MAP65/ASE1 family)
    pfam13094
    Location:34 → 130
    CENP-Q; CENP-Q, a CENPA-CAD centromere complex subunit

  2. NM_001285998.2 → NP_001272927.1  protein regulator of cytokinesis 1 isoform 3

    See identical proteins and their annotated locations for NP_001272927.1

    Status: VALIDATED

    Source sequence(s)
    AC109232, AC136740
    Consensus CDS
    CCDS71986.1
    UniProtKB/TrEMBL
    G3UY19, G3XA79
    Related
    ENSMUSP00000133910.2, ENSMUST00000173824.8
    Conserved Domains (1) summary
    pfam03999
    Location:37 → 560
    MAP65_ASE1; Microtubule associated protein (MAP65/ASE1 family)

  3. NM_001374624.1 → NP_001361553.1  protein regulator of cytokinesis 1 isoform 4

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) encodes the longest isoform (4).
    Source sequence(s)
    AC109232, AC136740
    Consensus CDS
    CCDS90258.1
    UniProtKB/TrEMBL
    G3UWQ7, G3XA79
    Related
    ENSMUSP00000133387.2, ENSMUST00000174172.8
    Conserved Domains (1) summary
    pfam03999
    Location:37 → 615
    MAP65_ASE1; Microtubule associated protein (MAP65/ASE1 family)

  4. NM_001382385.1 → NP_001369314.1  protein regulator of cytokinesis 1 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC109232, AC136740
    UniProtKB/TrEMBL
    G3XA79
    Conserved Domains (1) summary
    pfam03999
    Location:37 → 549
    MAP65_ASE1; Microtubule associated protein (MAP65/ASE1 family)

  5. NM_001382386.1 → NP_001369315.1  protein regulator of cytokinesis 1 isoform 6

    Status: VALIDATED

    Source sequence(s)
    AC109232, AC136740
    UniProtKB/TrEMBL
    G3XA79
    Conserved Domains (1) summary
    pfam03999
    Location:1 → 496
    MAP65_ASE1; Microtubule associated protein (MAP65/ASE1 family)

  6. NM_001382387.1 → NP_001369316.1  protein regulator of cytokinesis 1 isoform 7

    Status: VALIDATED

    Source sequence(s)
    AC109232, AC136740
    UniProtKB/TrEMBL
    G3XA79
    Conserved Domains (1) summary
    pfam03999
    Location:37 → 517
    MAP65_ASE1; Microtubule associated protein (MAP65/ASE1 family)

  7. NM_001382388.1 → NP_001369317.1  protein regulator of cytokinesis 1 isoform 8

    Status: VALIDATED

    Source sequence(s)
    AC109232, AC136740
    UniProtKB/TrEMBL
    G3XA79
    Conserved Domains (1) summary
    pfam03999
    Location:37 → 612
    MAP65_ASE1; Microtubule associated protein (MAP65/ASE1 family)

  8. NM_001382389.1 → NP_001369318.1  protein regulator of cytokinesis 1 isoform 9

    Status: VALIDATED

    Source sequence(s)
    AC109232, AC136740
    UniProtKB/TrEMBL
    G3XA79
    Conserved Domains (1) summary
    pfam03999
    Location:37 → 614
    MAP65_ASE1; Microtubule associated protein (MAP65/ASE1 family)

  9. NM_001382390.1 → NP_001369319.1  protein regulator of cytokinesis 1 isoform 10

    Status: VALIDATED

    Source sequence(s)
    AC109232, AC136740
    UniProtKB/TrEMBL
    G3XA79
    Conserved Domains (1) summary
    pfam03999
    Location:1 → 440
    MAP65_ASE1; Microtubule associated protein (MAP65/ASE1 family)

  10. NM_001420434.1 → NP_001407363.1  protein regulator of cytokinesis 1 isoform 11

    Status: VALIDATED

    Source sequence(s)
    AC109232, AC136740

  11. NM_145150.4 → NP_660132.2  protein regulator of cytokinesis 1 isoform 1

    See identical proteins and their annotated locations for NP_660132.2

    Status: VALIDATED

    Source sequence(s)
    AC109232, AC136740
    Consensus CDS
    CCDS39998.2
    UniProtKB/TrEMBL
    G3UW86, G3XA79
    Related
    ENSMUSP00000129675.3, ENSMUST00000163812.9
    Conserved Domains (2) summary
    pfam03999
    Location:37 → 601
    MAP65_ASE1; Microtubule associated protein (MAP65/ASE1 family)
    pfam13094
    Location:34 → 130
    CENP-Q; CENP-Q, a CENPA-CAD centromere complex subunit

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    79944224..79966007
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q99K43.2 GenPept UniProtKB/Swiss-Prot:Q99K43

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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