Samd4b sterile alpha motif domain containing 4B [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Samd4bprovided by MGI
Official Full Name: sterile alpha motif domain containing 4Bprovided by MGI
Primary source: MGI:MGI:2448542
See related: Ensembl:ENSMUSG00000109336 AllianceGenome:MGI:2448542
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary: Enables mRNA binding activity. Acts upstream of or within cerebellar neuron development. Predicted to be located in cytosol. Predicted to be active in P-body. Is expressed in cerebral cortex; cerebral cortex subventricular zone; cerebral cortex ventricular layer; cortical plate; and telencephalon. Orthologous to human SAMD4B (sterile alpha motif domain containing 4B). [provided by Alliance of Genome Resources, Jan 2025]
Expression: Ubiquitous expression in testis adult (RPKM 69.0), ovary adult (RPKM 36.9) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 7 A3; 7 16.73 cM

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	7	NC_000073.7 (28098947..28135616, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	7	NC_000073.6 (28399522..28436191, complement)

Chromosome 7 - NC_000073.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

A genome-wide transcriptomic analysis of embryos fathered by obese males in a murine model of diet-induced obesity.
Title: A genome-wide transcriptomic analysis of embryos fathered by obese males in a murine model of diet-induced obesity.
Smaug2 (and Nanos1) are critical regulators of neural stem cell differentiation and translational repression.
Title: A Smaug2-Based Translational Repression Complex Determines the Balance between Precursor Maintenance versus Differentiation during Mammalian Neurogenesis.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables mRNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables mRNA binding	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables translation repressor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within cerebellar neuron development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of translation	IEA Inferred from Electronic Annotation more info
involved_in nuclear-transcribed mRNA poly(A) tail shortening	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of mRNA stability	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in P-body	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: protein Smaug homolog 2

Names: mSmaug2; smaug 2; sterile alpha motif domain-containing protein 4B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.