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Zfp574 zinc finger protein 574 [ Mus musculus (house mouse) ]

Gene ID: 232976, updated on 27-Nov-2024

Summary

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Official Symbol
Zfp574provided by MGI
Official Full Name
zinc finger protein 574provided by MGI
Primary source
MGI:MGI:2442951
See related
Ensembl:ENSMUSG00000045252 AllianceGenome:MGI:2442951
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Znf574; A630056B21Rik
Summary
Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Is expressed in central nervous system; genitourinary system; and limb. Orthologous to human ZNF574 (zinc finger protein 574). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Broad expression in testis adult (RPKM 59.4), ovary adult (RPKM 14.9) and 24 other tissues See more
Orthologs
human all
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Genomic context

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See Zfp574 in Genome Data Viewer
Location:
7 A3; 7 13.73 cM
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (24775099..24782917)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (25075674..25083492)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E4905 Neighboring gene microRNA 7046 Neighboring gene Rab acceptor 1 (prenylated) Neighboring gene ATPase, Na+/K+ transporting, alpha 3 polypeptide Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:25785259-25785485 Neighboring gene microRNA 7047 Neighboring gene glutamate receptor, ionotropic, kainate 5 (gamma 2) Neighboring gene STARR-seq mESC enhancer starr_18288 Neighboring gene STARR-positive B cell enhancer ABC_E3704 Neighboring gene POU domain, class 2, transcription factor 2 Neighboring gene microRNA 6537 Neighboring gene STARR-seq mESC enhancer starr_18291 Neighboring gene STARR-positive B cell enhancer ABC_E2225 Neighboring gene STARR-positive B cell enhancer ABC_E6522 Neighboring gene STARR-positive B cell enhancer ABC_E3705 Neighboring gene RIKEN cDNA D930028M14 gene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Disruption of the ZFP574-THAP12 complex suppresses B cell malignancies in mice. Zhong X, et al. Proc Natl Acad Sci U S A, 2024 Jul 30. PMID 39047044,
  2. Interactome mapping of the phosphatidylinositol 3-kinase-mammalian target of rapamycin pathway identifies deformed epidermal autoregulatory factor-1 as a new glycogen synthase kinase-3 interactor. Pilot-Storck F, et al. Mol Cell Proteomics, 2010 Jul. PMID 20368287, Free PMC Article
  3. A systems approach reveals that the myogenesis genome network is regulated by the transcriptional repressor RP58. Yokoyama S, et al. Dev Cell, 2009 Dec. PMID 20059953, Free PMC Article
  4. Mouse brain organization revealed through direct genome-scale TF expression analysis. Gray PA, et al. Science, 2004 Dec 24. PMID 15618518
  5. EUCOMM--the European conditional mouse mutagenesis program. Friedel RH, et al. Brief Funct Genomic Proteomic, 2007 Sep. PMID 17967808

See all (22) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Disruption of the ZFP574-THAP12 complex suppresses B cell malignancies in mice.
    Title: Disruption of the ZFP574-THAP12 complex suppresses B cell malignancies in mice.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription activator activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
zinc finger protein 574

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001168506.2 → NP_001161978.1  zinc finger protein 574

    See identical proteins and their annotated locations for NP_001161978.1

    Status: VALIDATED

    Source sequence(s)
    AC125468, AK143997, BC059044
    Consensus CDS
    CCDS20971.1
    UniProtKB/Swiss-Prot
    Q3TDE5, Q3UNU1, Q8BKB5, Q8BY46
    Conserved Domains (2) summary
    COG5048
    Location:498 → 852
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:500 → 520
    ZF_C2H2; C2H2 Zn finger [structural motif]

  2. NM_175477.5 → NP_780686.1  zinc finger protein 574

    See identical proteins and their annotated locations for NP_780686.1

    Status: VALIDATED

    Source sequence(s)
    AC125468, AK143997, BC059044, BY087218
    Consensus CDS
    CCDS20971.1
    UniProtKB/Swiss-Prot
    Q3TDE5, Q3UNU1, Q8BKB5, Q8BY46
    Related
    ENSMUSP00000057817.10, ENSMUST00000053410.11
    Conserved Domains (2) summary
    COG5048
    Location:498 → 852
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:500 → 520
    ZF_C2H2; C2H2 Zn finger [structural motif]

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    24775099..24782917
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006539850.3 → XP_006539913.1  zinc finger protein 574 isoform X1

    Conserved Domains (2) summary
    COG5048
    Location:541 → 895
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:543 → 563
    ZF_C2H2; C2H2 Zn finger [structural motif]

  2. XM_006539852.5 → XP_006539915.1  zinc finger protein 574 isoform X2

    See identical proteins and their annotated locations for XP_006539915.1

    UniProtKB/Swiss-Prot
    Q3TDE5, Q3UNU1, Q8BKB5, Q8BY46
    Conserved Domains (2) summary
    COG5048
    Location:498 → 852
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:500 → 520
    ZF_C2H2; C2H2 Zn finger [structural motif]
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8BY46.1 GenPept UniProtKB/Swiss-Prot:Q8BY46

Gene LinkOut

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