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Klc3 kinesin light chain 3 [ Mus musculus (house mouse) ]

Gene ID: 232943, updated on 27-Nov-2024

Summary

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Official Symbol
Klc3provided by MGI
Official Full Name
kinesin light chain 3provided by MGI
Primary source
MGI:MGI:1277971
See related
Ensembl:ENSMUSG00000040714 AllianceGenome:MGI:1277971
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Klct
Summary
Enables kinesin binding activity and microtubule binding activity. Involved in sperm mitochondrial sheath assembly. Acts upstream of or within axo-dendritic transport. Located in several cellular components, including ciliary rootlet; mitochondrion; and motile cilium. Is expressed in cerebellum interpositus nucleus; deep cerebellar nucleus; dentate nucleus; fastigial nucleus; and vestibular nucleus. Orthologous to human KLC3 (kinesin light chain 3). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in thymus adult (RPKM 20.6), testis adult (RPKM 14.5) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Klc3 in Genome Data Viewer
Location:
7 A3; 7 9.62 cM
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (19128365..19138101, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (19394440..19404174, complement)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E6519 Neighboring gene protein phosphatase 1, regulatory subunit 13 like Neighboring gene STARR-seq mESC enhancer starr_18201 Neighboring gene STARR-positive B cell enhancer mm9_chr7:19967137-19967438 Neighboring gene excision repair cross-complementing rodent repair deficiency, complementation group 2 Neighboring gene microRNA 343 Neighboring gene predicted gene, 38954 Neighboring gene RIKEN cDNA A930016O22 gene Neighboring gene creatine kinase, muscle

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Targeted mutation and inactivation of the kinesin light chain 3 protein-encoding gene have no impact on mouse fertility†. Daniel-Carlier N, et al. Biol Reprod, 2024 Jan 13. PMID 37776549
  2. KLC3 is involved in sperm tail midpiece formation and sperm function. Zhang Y, et al. Dev Biol, 2012 Jun 15. PMID 22561200
  3. Disruption of the mouse xeroderma pigmentosum group D DNA repair/basal transcription gene results in preimplantation lethality. de Boer J, et al. Cancer Res, 1998 Jan 1. PMID 9426063
  4. KLC3 Regulates Ciliary Trafficking and Cyst Progression in CILK1 Deficiency-Related Polycystic Kidney Disease. Rah G, et al. J Am Soc Nephrol, 2022 Sep. PMID 35961787, Free PMC Article
  5. Sequence analysis of the ERCC2 gene regions in human, mouse, and hamster reveals three linked genes. Lamerdin JE, et al. Genomics, 1996 Jun 15. PMID 8786141

See all (30) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Targeted mutation and inactivation of the kinesin light chain 3 protein-encoding gene have no impact on mouse fertilitydagger.
    Title: Targeted mutation and inactivation of the kinesin light chain 3 protein-encoding gene have no impact on mouse fertility†.
  2. KLC3 Regulates Ciliary Trafficking and Cyst Progression in CILK1 Deficiency-Related Polycystic Kidney Disease.
    Title: KLC3 Regulates Ciliary Trafficking and Cyst Progression in CILK1 Deficiency-Related Polycystic Kidney Disease.
  3. KLC3 plays a role during spermiogenesis in the development of the midpiece and in the normal function of spermatozoa
    Title: KLC3 is involved in sperm tail midpiece formation and sperm function.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC28837

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables kinesin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables kinesin binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables microtubule binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within axo-dendritic transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within intraciliary transport TAS
Traceable Author Statement
more info
 PubMed 
involved_in microtubule-based movement IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in sperm mitochondrial sheath assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in spermatid development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in spermatogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in ciliary rootlet IDA
Inferred from Direct Assay
more info
 PubMed 
located_in ciliary rootlet IPI
Inferred from Physical Interaction
more info
 PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
part_of kinesin complex IEA
Inferred from Electronic Annotation
more info
  
located_in microtubule IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  
located_in motile cilium IDA
Inferred from Direct Assay
more info
 PubMed 
located_in neuron projection IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
kinesin light chain 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001286038.2 → NP_001272967.1  kinesin light chain 3 isoform a

    See identical proteins and their annotated locations for NP_001272967.1

    Status: VALIDATED

    Source sequence(s)
    AC118017
    Consensus CDS
    CCDS20901.1
    UniProtKB/Swiss-Prot
    Q3TZ56, Q91W40
    UniProtKB/TrEMBL
    D3Z710
    Related
    ENSMUSP00000038091.4, ENSMUST00000047170.10
    Conserved Domains (4) summary
    sd00006
    Location:291 → 319
    TPR; TPR repeat [structural motif]
    pfam00515
    Location:375 → 403
    TPR_1; Tetratricopeptide repeat
    pfam13374
    Location:290 → 331
    TPR_10; Tetratricopeptide repeat
    pfam13424
    Location:245 → 323
    TPR_12; Tetratricopeptide repeat

  2. NM_001286039.2 → NP_001272968.1  kinesin light chain 3 isoform a

    See identical proteins and their annotated locations for NP_001272968.1

    Status: VALIDATED

    Source sequence(s)
    AC118017
    Consensus CDS
    CCDS20901.1
    UniProtKB/Swiss-Prot
    Q3TZ56, Q91W40
    UniProtKB/TrEMBL
    D3Z710
    Related
    ENSMUSP00000104098.4, ENSMUST00000108458.10
    Conserved Domains (4) summary
    sd00006
    Location:291 → 319
    TPR; TPR repeat [structural motif]
    pfam00515
    Location:375 → 403
    TPR_1; Tetratricopeptide repeat
    pfam13374
    Location:290 → 331
    TPR_10; Tetratricopeptide repeat
    pfam13424
    Location:245 → 323
    TPR_12; Tetratricopeptide repeat

  3. NM_001403685.1 → NP_001390614.1  kinesin light chain 3 isoform b

    Status: VALIDATED

    Source sequence(s)
    AC118017
    Related
    ENSMUSP00000104097.2, ENSMUST00000108457.3

  4. NM_146182.5 → NP_666294.1  kinesin light chain 3 isoform a

    See identical proteins and their annotated locations for NP_666294.1

    Status: VALIDATED

    Source sequence(s)
    AC118017
    Consensus CDS
    CCDS20901.1
    UniProtKB/Swiss-Prot
    Q3TZ56, Q91W40
    UniProtKB/TrEMBL
    D3Z710
    Related
    ENSMUSP00000104099.3, ENSMUST00000108459.9
    Conserved Domains (4) summary
    sd00006
    Location:291 → 319
    TPR; TPR repeat [structural motif]
    pfam00515
    Location:375 → 403
    TPR_1; Tetratricopeptide repeat
    pfam13374
    Location:290 → 331
    TPR_10; Tetratricopeptide repeat
    pfam13424
    Location:245 → 323
    TPR_12; Tetratricopeptide repeat

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    19128365..19138101 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030242434.2 → XP_030098294.1  kinesin light chain 3 isoform X4

    UniProtKB/TrEMBL
    D3Z710
    Conserved Domains (3) summary
    TIGR02168
    Location:21 → 148
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    sd00006
    Location:291 → 319
    TPR; TPR repeat [structural motif]
    pfam13424
    Location:247 → 323
    TPR_12; Tetratricopeptide repeat

  2. XM_030242432.1 → XP_030098292.1  kinesin light chain 3 isoform X1

    UniProtKB/TrEMBL
    D3Z710
    Conserved Domains (3) summary
    TIGR02168
    Location:26 → 153
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    sd00006
    Location:296 → 324
    TPR; TPR repeat [structural motif]
    pfam13424
    Location:252 → 328
    TPR_12; Tetratricopeptide repeat

  3. XM_017322153.2 → XP_017177642.1  kinesin light chain 3 isoform X2

    UniProtKB/TrEMBL
    D3Z710
    Conserved Domains (3) summary
    TIGR02168
    Location:26 → 153
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    sd00006
    Location:296 → 324
    TPR; TPR repeat [structural motif]
    pfam13424
    Location:252 → 328
    TPR_12; Tetratricopeptide repeat

  4. XM_030242435.2 → XP_030098295.1  kinesin light chain 3 isoform X4

    UniProtKB/TrEMBL
    D3Z710
    Conserved Domains (3) summary
    TIGR02168
    Location:21 → 148
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    sd00006
    Location:291 → 319
    TPR; TPR repeat [structural motif]
    pfam13424
    Location:247 → 323
    TPR_12; Tetratricopeptide repeat
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q91W40.1 GenPept UniProtKB/Swiss-Prot:Q91W40

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