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Ppp1r12c protein phosphatase 1, regulatory subunit 12C [ Mus musculus (house mouse) ]

Gene ID: 232807, updated on 27-Nov-2024

Summary

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Official Symbol
Ppp1r12cprovided by MGI
Official Full Name
protein phosphatase 1, regulatory subunit 12Cprovided by MGI
Primary source
MGI:MGI:1924258
See related
Ensembl:ENSMUSG00000019254 AllianceGenome:MGI:1924258
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Mbs85; B430101M08; 2410197A17Rik
Summary
Predicted to enable enzyme inhibitor activity and myosin phosphatase regulator activity. Predicted to be involved in neuron projection morphogenesis. Predicted to be located in stress fiber. Predicted to be active in cytoplasm. Is expressed in limb mesenchyme. Orthologous to human PPP1R12C (protein phosphatase 1 regulatory subunit 12C). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in colon adult (RPKM 29.1), lung adult (RPKM 21.9) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Ppp1r12c in Genome Data Viewer
Location:
7 A1; 7 2.59 cM
Exon count:
22
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (4484518..4506762, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (4481519..4503763, complement)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene ATPase, H+ transporting, lysosomal V0 subunit C, pseudogene 1 Neighboring gene STARR-positive B cell enhancer ABC_E1718 Neighboring gene retinol dehydrogenase 13 (all-trans and 9-cis) Neighboring gene STARR-positive B cell enhancer ABC_E9682 Neighboring gene RIKEN cDNA D630041G03 gene Neighboring gene EPS8-like 1 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:4461475-4461662 Neighboring gene troponin T1, skeletal, slow Neighboring gene troponin I, cardiac 3 Neighboring gene dynein, axonemal assembly factor 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Actin cytoskeleton remodeling primes RIG-I-like receptor activation. Acharya D, et al. Cell, 2022 Sep 15. PMID 36113429, Free PMC Article
  2. TRIM27 cooperates with STK38L to inhibit ULK1-mediated autophagy and promote tumorigenesis. Yang Y, et al. EMBO J, 2022 Jul 18. PMID 35670107, Free PMC Article
  3. Epilepsy- and intellectual disability-associated CYFIP2 interacts with both actin regulators and RNA-binding proteins in the neonatal mouse forebrain. Lee Y, et al. Biochem Biophys Res Commun, 2020 Aug 13. PMID 32560809
  4. Rearrangement of the Protein Phosphatase 1 Interactome During Heart Failure Progression. Chiang DY, et al. Circulation, 2018 Oct 9. PMID 29669786, Free PMC Article
  5. KCTD13-mediated ubiquitination and degradation of GluN1 regulates excitatory synaptic transmission and seizure susceptibility. Gu J, et al. Cell Death Differ, 2023 Jul. PMID 37142655, Free PMC Article

See all (21) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Targeted (2) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables enzyme inhibitor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables myosin phosphatase regulator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables phosphatase regulator activity IEA
Inferred from Electronic Annotation
more info
  
enables protein kinase binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in neuron projection morphogenesis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in stress fiber IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
protein phosphatase 1 regulatory subunit 12C
Names
myosin-binding subunit 85
protein phosphatase 1 myosin-binding subunit of 85 kDa
protein phosphatase 1 myosin-binding subunit p85
protein phosphatase 1, regulatory (inhibitor) subunit 12C

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001419228.1 → NP_001406157.1  protein phosphatase 1 regulatory subunit 12C isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC161218
    Related
    ENSMUSP00000120029.2, ENSMUST00000124248.8

  2. NM_001419230.1 → NP_001406159.1  protein phosphatase 1 regulatory subunit 12C isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC161218

  3. NM_029834.4 → NP_084110.2  protein phosphatase 1 regulatory subunit 12C isoform 1

    See identical proteins and their annotated locations for NP_084110.2

    Status: VALIDATED

    Source sequence(s)
    AC161218
    Consensus CDS
    CCDS39735.1
    UniProtKB/Swiss-Prot
    Q3UMT1, Q9CWD5
    UniProtKB/TrEMBL
    F6XWD4
    Related
    ENSMUSP00000013886.9, ENSMUST00000013886.9
    Conserved Domains (5) summary
    cd00204
    Location:99 → 283
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam12796
    Location:109 → 261
    Ank_2; Ankyrin repeats (3 copies)
    pfam13637
    Location:264 → 312
    Ank_4; Ankyrin repeats (many copies)
    pfam15898
    Location:683 → 781
    PRKG1_interact; cGMP-dependent protein kinase interacting domain
    sd00045
    Location:104 → 135
    ANK; ANK repeat [structural motif]

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    4484518..4506762 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011250502.3 → XP_011248804.1  protein phosphatase 1 regulatory subunit 12C isoform X2

    UniProtKB/TrEMBL
    F6XWD4
    Conserved Domains (5) summary
    COG0666
    Location:1 → 175
    ANKYR; Ankyrin repeat [Signal transduction mechanisms]
    PRK12678
    Location:361 → 550
    PRK12678; transcription termination factor Rho; Provisional
    sd00045
    Location:83 → 114
    ANK; ANK repeat [structural motif]
    pfam12796
    Location:88 → 140
    Ank_2; Ankyrin repeats (3 copies)
    pfam15898
    Location:537 → 635
    PRKG1_interact; cGMP-dependent protein kinase interacting domain

RNA

  1. XR_881691.3 RNA Sequence

  2. XR_391056.4 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q3UMT1.1 GenPept UniProtKB/Swiss-Prot:Q3UMT1

Gene LinkOut

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