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Fkbp14 FK506 binding protein 14 [ Mus musculus (house mouse) ]

Gene ID: 231997, updated on 27-Nov-2024

Summary

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Official Symbol
Fkbp14provided by MGI
Official Full Name
FK506 binding protein 14provided by MGI
Primary source
MGI:MGI:2387639
See related
Ensembl:ENSMUSG00000038074 AllianceGenome:MGI:2387639
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
FKBP22; FKBP-14
Summary
Predicted to enable calcium ion binding activity and peptidyl-prolyl cis-trans isomerase activity. Predicted to be located in endoplasmic reticulum lumen. Is expressed in cerebral cortex ventricular layer; cranium; jaw; and thoracic segment skeleton. Human ortholog(s) of this gene implicated in Ehlers-Danlos syndrome kyphoscoliotic type 2. Orthologous to human FKBP14 (FKBP prolyl isomerase 14). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Broad expression in limb E14.5 (RPKM 15.3), bladder adult (RPKM 8.2) and 20 other tissues See more
Orthologs
human all
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Genomic context

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See Fkbp14 in Genome Data Viewer
Location:
6 B3; 6 27.01 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (54554590..54574329, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (54577602..54597344, complement)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene WAS/WASL interacting protein family, member 3 Neighboring gene predicted gene, 44026 Neighboring gene secernin 1 Neighboring gene predicted gene, 52863 Neighboring gene pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 8 Neighboring gene STARR-seq mESC enhancer starr_15954 Neighboring gene predicted gene, 34249 Neighboring gene maturin, neural progenitor differentiation regulator homolog (Xenopus) Neighboring gene predicted gene, 44008

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Targeting a complex transcriptome: the construction of the mouse full-length cDNA encyclopedia. Carninci P, et al. Genome Res, 2003 Jun. PMID 12819125, Free PMC Article
  2. Mapping the NPHP-JBTS-MKS protein network reveals ciliopathy disease genes and pathways. Sang L, et al. Cell, 2011 May 13. PMID 21565611, Free PMC Article
  3. Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development. Bedogni F, et al. Front Mol Neurosci, 2021. PMID 34321999, Free PMC Article
  4. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
  5. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Clone Names

  • MGC18737

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables RNA polymerase II CTD heptapeptide repeat P3 isomerase activity IEA
Inferred from Electronic Annotation
more info
  
enables RNA polymerase II CTD heptapeptide repeat P6 isomerase activity IEA
Inferred from Electronic Annotation
more info
  
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in endoplasmic reticulum lumen IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
peptidyl-prolyl cis-trans isomerase FKBP14
Names
PPIase FKBP14
rotamase
NP_001350721.1
NP_001350722.1
NP_001398495.1
NP_001398496.1
NP_001398497.1
NP_705801.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001363792.1 → NP_001350721.1  peptidyl-prolyl cis-trans isomerase FKBP14 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AK163384, BC024846
    Consensus CDS
    CCDS90048.1
    UniProtKB/TrEMBL
    D3YWB6, Q3TQQ3
    Related
    ENSMUSP00000112526.2, ENSMUST00000117375.2
    Conserved Domains (2) summary
    pfam13499
    Location:47 → 110
    EF-hand_7; EF-hand domain pair
    cl27578
    Location:1 → 41
    FKBP_N; Domain amino terminal to FKBP-type peptidyl-prolyl isomerase

  2. NM_001363793.1 → NP_001350722.1  peptidyl-prolyl cis-trans isomerase FKBP14 isoform 3

    Status: VALIDATED

    Source sequence(s)
    BC034313, BY775871
    UniProtKB/TrEMBL
    Q05BQ9
    Conserved Domains (2) summary
    COG0545
    Location:26 → 45
    FkpA; FKBP-type peptidyl-prolyl cis-trans isomerase [Posttranslational modification, protein turnover, chaperones]
    pfam13499
    Location:51 → 114
    EF-hand_7; EF-hand domain pair

  3. NM_001411566.1 → NP_001398495.1  peptidyl-prolyl cis-trans isomerase FKBP14 isoform 4 precursor

    Status: VALIDATED

    Source sequence(s)
    AC084800

  4. NM_001411567.1 → NP_001398496.1  peptidyl-prolyl cis-trans isomerase FKBP14 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC084800
    UniProtKB/TrEMBL
    Q05BQ9

  5. NM_001411568.1 → NP_001398497.1  peptidyl-prolyl cis-trans isomerase FKBP14 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC084800

  6. NM_153573.2 → NP_705801.1  peptidyl-prolyl cis-trans isomerase FKBP14 isoform 1 precursor

    See identical proteins and their annotated locations for NP_705801.1

    Status: VALIDATED

    Source sequence(s)
    AK081692, BC024846, BY775871
    Consensus CDS
    CCDS20157.1
    UniProtKB/Swiss-Prot
    P59024
    UniProtKB/TrEMBL
    Q542Q0
    Related
    ENSMUSP00000046070.7, ENSMUST00000046520.13
    Conserved Domains (3) summary
    pfam00254
    Location:38 → 132
    FKBP_C; FKBP-type peptidyl-prolyl cis-trans isomerase
    pfam13499
    Location:141 → 204
    EF-hand_7; EF-hand domain pair
    cl08302
    Location:142 → 204
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

RNA

  1. NR_177283.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC084800

  2. NR_177284.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC084800
    Related
    ENSMUST00000155047.6

  3. NR_177285.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC084800

  4. NR_177286.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC084800

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    54554590..54574329 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P59024.1 GenPept UniProtKB/Swiss-Prot:P59024

Gene LinkOut

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