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Oscp1 organic solute carrier partner 1 [ Mus musculus (house mouse) ]

Gene ID: 230751, updated on 27-Nov-2024

Summary

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Official Symbol
Oscp1provided by MGI
Official Full Name
organic solute carrier partner 1provided by MGI
Primary source
MGI:MGI:1916308
See related
Ensembl:ENSMUSG00000042616 AllianceGenome:MGI:1916308
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
5730415O04; 1810007P19Rik; 6030436A01Rik
Summary
Predicted to enable transmembrane transporter activity. Predicted to be involved in xenobiotic detoxification by transmembrane export across the plasma membrane. Located in cytoplasm. Is expressed in several structures, including brain ventricle; heart ventricle; and olfactory epithelium. Orthologous to human OSCP1 (organic solute carrier partner 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in testis adult (RPKM 14.5), frontal lobe adult (RPKM 1.7) and 7 other tissues See more
Orthologs
human all
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Genomic context

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See Oscp1 in Genome Data Viewer
Location:
4 D2.2; 4 59.82 cM
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (125949436..125985988)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (126055643..126092195)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 32908 Neighboring gene colony stimulating factor 3 receptor Neighboring gene STARR-positive B cell enhancer ABC_E2121 Neighboring gene mitochondrial ribosomal protein S15 Neighboring gene STARR-positive B cell enhancer ABC_E3512 Neighboring gene ribosomal protein L28, pseudogene 3 Neighboring gene STARR-positive B cell enhancer ABC_E2712 Neighboring gene STARR-positive B cell enhancer ABC_E2713 Neighboring gene U7 snRNP-specific Sm-like protein LSM10 Neighboring gene serine/threonine kinase 40

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Neuronal expression, cytosolic localization, and developmental regulation of the organic solute carrier partner 1 in the mouse brain. Hiratsuka K, et al. Histochem Cell Biol, 2011 Mar. PMID 21331566
  2. Isolation and characterization of polyspecific mouse organic solute carrier protein 1 (mOscp1). Kobayashi Y, et al. Drug Metab Dispos, 2007 Jul. PMID 17446263
  3. Abberent expression of NOR1 protein in tumor associated macrophages contributes to the development of DEN-induced hepatocellular carcinoma. Chen S, et al. J Cell Physiol, 2018 Jun. PMID 29227538
  4. Isolation and functional characterization of a novel organic solute carrier protein, hOSCP1. Kobayashi Y, et al. J Biol Chem, 2005 Sep 16. PMID 16006562
  5. Intratesticular localization of the organic solute carrier protein, OSCP1, in spermatogenic cells in mice. Hiratsuka K, et al. Mol Reprod Dev, 2008 Oct. PMID 18324622

See all (22) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Abberant expression of NOR1 protein in tumor associated macrophages contributes to the development of DEN-induced hepatocellular carcinoma
    Title: Abberent expression of NOR1 protein in tumor associated macrophages contributes to the development of DEN-induced hepatocellular carcinoma.
  2. The results indicate that OSCP1 may have a role in the brain indirectly mediating substrate uptake into the neurons in adult animals.
    Title: Neuronal expression, cytosolic localization, and developmental regulation of the organic solute carrier partner 1 in the mouse brain.
  3. mouse testis OSCP1 may indirectly mediate substrate uptake into meiotic and spermiogenic germ cells, within the cytosol.
    Title: Intratesticular localization of the organic solute carrier protein, OSCP1, in spermatogenic cells in mice.
  4. Report molecular cloning/functional characterization of Oscp1 from mouse testes.
    Title: Isolation and characterization of polyspecific mouse organic solute carrier protein 1 (mOscp1).
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Targeted (3)  1 citation

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in xenobiotic detoxification by transmembrane export across the plasma membrane ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in basal plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in basal plasma membrane ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
protein OSCP1
Names
organic solute carrier 1
organic solute carrier protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001356446.1 → NP_001343375.1  protein OSCP1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AI853667, AK077909, AL627101
    Consensus CDS
    CCDS89827.1
    UniProtKB/TrEMBL
    A0ZV96
    Related
    ENSMUSP00000152196.2, ENSMUST00000143712.3
    Conserved Domains (1) summary
    pfam10188
    Location:18 → 199
    Oscp1; Organic solute transport protein 1

  2. NM_172701.3 → NP_766289.2  protein OSCP1 isoform 1

    See identical proteins and their annotated locations for NP_766289.2

    Status: VALIDATED

    Source sequence(s)
    AI853667, AK077909, AL627101
    Consensus CDS
    CCDS38879.1
    UniProtKB/Swiss-Prot
    Q8BHQ7, Q8BHW2
    UniProtKB/TrEMBL
    A2A8Y5
    Related
    ENSMUSP00000045241.5, ENSMUST00000035497.5
    Conserved Domains (1) summary
    pfam10188
    Location:18 → 189
    Oscp1; Organic solute transport protein 1

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    125949436..125985988
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006503034.4 → XP_006503097.1  protein OSCP1 isoform X1

    Conserved Domains (1) summary
    pfam10188
    Location:49 → 201
    Oscp1; Organic solute transport protein 1

RNA

  1. XR_004941873.1 RNA Sequence

  2. XR_003954925.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8BHW2.1 GenPept UniProtKB/Swiss-Prot:Q8BHW2

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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