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Trmt13 tRNA methyltransferase 13 [ Mus musculus (house mouse) ]

Gene ID: 229780, updated on 4-Jan-2025

Summary

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Official Symbol
Trmt13provided by MGI
Official Full Name
tRNA methyltransferase 13provided by MGI
Primary source
MGI:MGI:1925219
See related
Ensembl:ENSMUSG00000033439 AllianceGenome:MGI:1925219
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Ccdc76; A330067P21; 4631408H19Rik; A930028L21Rik
Summary
Predicted to enable tRNA methyltransferase activity. Predicted to be involved in tRNA methylation. Orthologous to human TRMT13 (tRNA methyltransferase 13 homolog). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Broad expression in heart adult (RPKM 5.5), CNS E11.5 (RPKM 4.6) and 22 other tissues See more
Orthologs
human all
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Genomic context

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See Trmt13 in Genome Data Viewer
Location:
3 G1; 3 50.4 cM
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (116365706..116408236, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (116576061..116614587, complement)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene dihydrolipoamide branched chain transacylase E2 Neighboring gene ubiquitin-conjugating enzyme E2D 3 (UBC4/5 homolog, yeast) pseudogene Neighboring gene splicing factor, arginine/serine-rich pseudogene Neighboring gene leucine rich repeat containing 39 Neighboring gene STARR-seq mESC enhancer starr_08780 Neighboring gene STARR-positive B cell enhancer ABC_E1630 Neighboring gene SAS-6 centriolar assembly protein Neighboring gene STARR-seq mESC enhancer starr_08781 Neighboring gene STARR-seq mESC enhancer starr_08784 Neighboring gene major facilitator superfamily domain containing 14A Neighboring gene STARR-seq mESC enhancer starr_08785 Neighboring gene STARR-positive B cell enhancer ABC_E3464 Neighboring gene STARR-seq mESC enhancer starr_08789 Neighboring gene microRNA 3473h

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. tRNA modifications regulate translation during cellular stress. Gu C, et al. FEBS Lett, 2014 Nov 28. PMID 25304425, Free PMC Article
  2. Diversity in mechanism and function of tRNA methyltransferases. Swinehart WE, et al. RNA Biol, 2015. PMID 25626150, Free PMC Article
  3. BayGenomics: a resource of insertional mutations in mouse embryonic stem cells. Stryke D, et al. Nucleic Acids Res, 2003 Jan 1. PMID 12520002, Free PMC Article
  4. Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray. Tanaka TS, et al. Proc Natl Acad Sci U S A, 2000 Aug 1. PMID 10922068, Free PMC Article
  5. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables tRNA 2'-O-methyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables tRNA methyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in tRNA methylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in tRNA methylation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  

General protein information

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Preferred Names
tRNA:m(4)X modification enzyme TRM13 homolog
Names
coiled-coil domain containing 76
coiled-coil domain-containing protein 76
tRNA [Gm4] methyltransferase
tRNA guanosine-2'-O-methyltransferase TRM13 homolog
tRNA methyltransferase 13 homolog
NP_084292.1
XP_006501487.1
XP_011238413.1
XP_011238414.1
XP_030108459.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_030016.3 → NP_084292.1  tRNA:m(4)X modification enzyme TRM13 homolog

    See identical proteins and their annotated locations for NP_084292.1

    Status: VALIDATED

    Source sequence(s)
    AC131038, AK039588
    Consensus CDS
    CCDS38612.1
    UniProtKB/Swiss-Prot
    Q8BYH3
    Related
    ENSMUSP00000047320.5, ENSMUST00000041524.11
    Conserved Domains (3) summary
    pfam05206
    Location:165 → 469
    TRM13; Methyltransferase TRM13
    pfam05253
    Location:59 → 80
    zf-U11-48K; U11-48K-like CHHC zinc finger
    pfam11722
    Location:17 → 45
    zf-TRM13_CCCH; CCCH zinc finger in TRM13 protein

RNA

  1. NR_152258.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC131038, AK041636, AK163561

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    116365706..116408236 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030252599.2 → XP_030108459.1  tRNA:m(4)X modification enzyme TRM13 homolog isoform X3

    UniProtKB/TrEMBL
    V9GWW9
    Related
    ENSMUSP00000138868.2, ENSMUST00000184963.8
    Conserved Domains (3) summary
    pfam05253
    Location:59 → 80
    zf-U11-48K; U11-48K-like CHHC zinc finger
    pfam11722
    Location:17 → 45
    zf-TRM13_CCCH; CCCH zinc finger in TRM13 protein
    cl17173
    Location:165 → 273
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

  2. XM_006501424.3 → XP_006501487.1  tRNA:m(4)X modification enzyme TRM13 homolog isoform X2

    See identical proteins and their annotated locations for XP_006501487.1

    Conserved Domains (1) summary
    pfam05206
    Location:24 → 328
    TRM13; Methyltransferase TRM13

  3. XM_011240112.3 → XP_011238414.1  tRNA:m(4)X modification enzyme TRM13 homolog isoform X2

    See identical proteins and their annotated locations for XP_011238414.1

    Conserved Domains (1) summary
    pfam05206
    Location:24 → 328
    TRM13; Methyltransferase TRM13

  4. XM_011240111.2 → XP_011238413.1  tRNA:m(4)X modification enzyme TRM13 homolog isoform X1

    Conserved Domains (1) summary
    pfam05206
    Location:84 → 388
    TRM13; Methyltransferase TRM13
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8BYH3.1 GenPept UniProtKB/Swiss-Prot:Q8BYH3

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