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Chil5 chitinase-like 5 [ Mus musculus (house mouse) ]

Gene ID: 229687, updated on 27-Nov-2024

Summary

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Official Symbol
Chil5provided by MGI
Official Full Name
chitinase-like 5provided by MGI
Primary source
MGI:MGI:2676649
See related
Ensembl:ENSMUSG00000043873 AllianceGenome:MGI:2676649
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Bclp; Bclp1; Bclp2; Chi3l7
Summary
Predicted to enable chitin binding activity; chitinase activity; and kinase binding activity. Predicted to be involved in chitin catabolic process; positive regulation of chemokine production; and production of molecular mediator involved in inflammatory response. Predicted to be located in extracellular space. Predicted to be active in extracellular region. Is expressed in lung. Human ortholog(s) of this gene implicated in asthma. Orthologous to human CHIA (chitinase acidic). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Low expression observed in reference dataset See more
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Genomic context

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See Chil5 in Genome Data Viewer
Location:
3 F2.2; 3 46.47 cM
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (105924235..105940262, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (106016919..106032949, complement)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene oviductal glycoprotein 1 Neighboring gene STARR-positive B cell enhancer ABC_E6099 Neighboring gene ciliary microtubule associated protein 3 Neighboring gene STARR-seq mESC enhancer starr_08642 Neighboring gene predicted gene 42722 Neighboring gene STARR-seq mESC enhancer starr_08643 Neighboring gene predicted gene 4540 Neighboring gene uncharacterized protein C9orf85 homolog pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Spontaneous Chitin Accumulation in Airways and Age-Related Fibrotic Lung Disease. Van Dyken SJ, et al. Cell, 2017 Apr 20. PMID 28431248, Free PMC Article
  2. New paralogues and revised time line in the expansion of the vertebrate GH18 family. Hussain M, et al. J Mol Evol, 2013 Apr. PMID 23558346
  3. Nell1-deficient mice have reduced expression of extracellular matrix proteins causing cranial and vertebral defects. Desai J, et al. Hum Mol Genet, 2006 Apr 15. PMID 16537572
  4. BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system. Magdaleno S, et al. PLoS Biol, 2006 Apr. PMID 16602821, Free PMC Article
  5. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

General gene information

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Markers

Homology

Clone Names

  • MGC156874

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables chitin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables chitinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables chitinase activity ISO
Inferred from Sequence Orthology
more info
  
enables kinase binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in chitin catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in chitin catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of chemokine production ISO
Inferred from Sequence Orthology
more info
  
involved_in production of molecular mediator involved in inflammatory response ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in extracellular region IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
chitinase like
Names
chitinase 3-like 7
chitinase like protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001080816.2 → NP_001074285.1  chitinase like precursor

    Status: VALIDATED

    Source sequence(s)
    AB081756, AC025786, AI851591, BC116403
    Consensus CDS
    CCDS38584.1
    UniProtKB/TrEMBL
    A0A0G2JDS2
    Related
    ENSMUSP00000142477.2, ENSMUST00000200146.2
    Conserved Domains (2) summary
    cd02872
    Location:24 → 387
    GH18_chitolectin_chitotriosidase; This conserved domain family includes a large number of catalytically inactive chitinase-like lectins (chitolectins) including YKL-39, YKL-40 (HCGP39), YM1, oviductin, and AMCase (acidic mammalian chitinase), as well as catalytically active ...
    smart00636
    Location:26 → 365
    Glyco_18; Glyco_18 domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    105924235..105940262 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006502521.5 → XP_006502584.1  chitinase like isoform X1

    See identical proteins and their annotated locations for XP_006502584.1

    Conserved Domains (1) summary
    cl10447
    Location:24 → 304
    GH18_chitinase-like; The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods. Chitinases have ...

  2. XM_006502522.5 → XP_006502585.1  chitinase like isoform X2

    See identical proteins and their annotated locations for XP_006502585.1

    Conserved Domains (1) summary
    cl10447
    Location:24 → 271
    GH18_chitinase-like; The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods. Chitinases have ...

  3. XM_006502523.4 → XP_006502586.1  chitinase like isoform X3

    See identical proteins and their annotated locations for XP_006502586.1

    UniProtKB/TrEMBL
    A0JP54, F7AQE8
    Related
    ENSMUSP00000065043.5, ENSMUST00000066537.10
    Conserved Domains (1) summary
    cl10447
    Location:1 → 196
    GH18_chitinase-like; The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods. Chitinases have ...

  4. XM_006502524.5 → XP_006502587.1  chitinase like isoform X4

    See identical proteins and their annotated locations for XP_006502587.1

    UniProtKB/TrEMBL
    Q08EE2
    Conserved Domains (1) summary
    cl10447
    Location:11 → 194
    GH18_chitinase-like; The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods. Chitinases have ...

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_170594.1: Suppressed sequence

    Description
    NM_170594.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.

  2. NM_201246.1: Suppressed sequence

    Description
    NM_201246.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
Nucleotide Protein Strain
Heading Accession and Version

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