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BC028528 cDNA sequence BC028528 [ Mus musculus (house mouse) ]

Gene ID: 229600, updated on 27-Nov-2024

Summary

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Official Symbol
BC028528provided by MGI
Official Full Name
cDNA sequence BC028528provided by MGI
Primary source
MGI:MGI:2385885
See related
Ensembl:ENSMUSG00000038543 AllianceGenome:MGI:2385885
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
L259
Summary
Acts upstream of or within epithelial cell proliferation involved in renal tubule morphogenesis; phosphatidylinositol 3-kinase/protein kinase B signal transduction; and response to wounding. Predicted to be located in extracellular region. Orthologous to human C1orf54 (chromosome 1 open reading frame 54). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Broad expression in lung adult (RPKM 15.9), bladder adult (RPKM 3.2) and 21 other tissues See more
Orthologs
human all
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Genomic context

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See BC028528 in Genome Data Viewer
Location:
3 F2.1; 3 41.44 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (95789665..95800186, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (95883945..95892062, complement)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene pre-mRNA processing factor 3 Neighboring gene STARR-positive B cell enhancer ABC_E10199 Neighboring gene RIKEN cDNA C920021L13 gene Neighboring gene mitochondrial ribosomal protein S21 Neighboring gene STARR-positive B cell enhancer ABC_E9562 Neighboring gene circadian associated repressor of transcription Neighboring gene STARR-positive B cell enhancer ABC_E2673 Neighboring gene aph1 homolog A, gamma secretase subunit Neighboring gene carbonic anhydrase 14 Neighboring gene CapStarr-seq enhancer MGSCv37_chr3:95732686-95732932 Neighboring gene predicted gene, 46815

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Tubular epithelial C1orf54 mediates protection and recovery from acute kidney injury. Xie H, et al. J Cell Mol Med, 2018 Oct. PMID 29999589, Free PMC Article
  2. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article
  3. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548
  4. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Targeted (3)  1 citation

General gene information

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Homology

Clone Names

  • MGC41379

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
acts_upstream_of_or_within epithelial cell proliferation involved in renal tubule morphogenesis IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within epithelial cell proliferation involved in renal tubule morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within phosphatidylinositol 3-kinase/protein kinase B signal transduction IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within response to wounding IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
uncharacterized protein C1orf54 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001346514.2 → NP_001333443.1  uncharacterized protein C1orf54 homolog isoform 2 precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) contains an alternate in-frame splice site in the 3' coding region, compared to variant 1. It encodes isoform 2, which is shorter than isoform 1.
    Source sequence(s)
    AC092855
    Consensus CDS
    CCDS84656.1
    UniProtKB/Swiss-Prot
    Q8R2K8
    Related
    ENSMUSP00000046810.7, ENSMUST00000036360.13
    Conserved Domains (1) summary
    pfam15465
    Location:1 → 145
    DUF4634; Domain of unknown function (DUF4634)

  2. NM_001399777.1 → NP_001386706.1  uncharacterized protein C1orf54 homolog isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC092855

  3. NM_153513.4 → NP_705733.2  uncharacterized protein C1orf54 homolog isoform 1 precursor

    See identical proteins and their annotated locations for NP_705733.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC092855
    Consensus CDS
    CCDS50998.1
    UniProtKB/Swiss-Prot
    Q8K3T8, Q8R2K8
    Related
    ENSMUSP00000102749.2, ENSMUST00000090476.10
    Conserved Domains (1) summary
    pfam15465
    Location:1 → 146
    DUF4634; Domain of unknown function (DUF4634)

RNA

  1. NR_166867.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC092855

  2. NR_166868.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC092855

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    95789665..95800186 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036163066.1 → XP_036018959.1  uncharacterized protein C1orf54 homolog isoform X3

    Conserved Domains (1) summary
    pfam15465
    Location:1 → 106
    DUF4634; Domain of unknown function (DUF4634)

  2. XM_006501379.2 → XP_006501442.1  uncharacterized protein C1orf54 homolog isoform X4

    Conserved Domains (1) summary
    pfam15465
    Location:1 → 141
    DUF4634; Domain of unknown function (DUF4634)

  3. XM_036163065.1 → XP_036018958.1  uncharacterized protein C1orf54 homolog isoform X2

    Conserved Domains (1) summary
    pfam15465
    Location:6 → 98
    DUF4634; Domain of unknown function (DUF4634)

  4. XM_011240095.4 → XP_011238397.1  uncharacterized protein C1orf54 homolog isoform X1

    Conserved Domains (1) summary
    pfam15465
    Location:1 → 106
    DUF4634; Domain of unknown function (DUF4634)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8R2K8.2 GenPept UniProtKB/Swiss-Prot:Q8R2K8

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