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Tlk1 tousled-like kinase 1 [ Mus musculus (house mouse) ]

Gene ID: 228012, updated on 27-Nov-2024

Summary

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Official Symbol
Tlk1provided by MGI
Official Full Name
tousled-like kinase 1provided by MGI
Primary source
MGI:MGI:2441683
See related
Ensembl:ENSMUSG00000041997 AllianceGenome:MGI:2441683
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
4930545J15Rik
Summary
Predicted to enable ATP binding activity and protein serine/threonine kinase activity. Predicted to be involved in several processes, including intracellular protein transport; protein phosphorylation; and regulation of chromatin organization. Predicted to be located in nucleoplasm. Predicted to be active in nucleus. Is expressed in several structures, including alimentary system; brain; cardiovascular system; genitourinary system; and hemolymphoid system gland. Orthologous to human TLK1 (tousled like kinase 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in liver E14 (RPKM 13.5), liver E14.5 (RPKM 11.1) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Tlk1 in Genome Data Viewer
Location:
2 C2; 2 41.9 cM
Exon count:
24
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (70542751..70656505, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (70712407..70825816, complement)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene predicted gene, 46745 Neighboring gene STARR-positive B cell enhancer ABC_E7823 Neighboring gene golgi reassembly stacking protein 2 Neighboring gene STARR-seq mESC enhancer starr_04765 Neighboring gene predicted gene, 38528 Neighboring gene STARR-seq mESC enhancer starr_04766 Neighboring gene STARR-seq mESC enhancer starr_04767 Neighboring gene STARR-positive B cell enhancer ABC_E11136 Neighboring gene STARR-positive B cell enhancer ABC_E10112 Neighboring gene predicted gene, 39842 Neighboring gene F-box and WD-40 domain protein 2 pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. CircTLK1: A novel regulator involved in VSMC phenotypic switching and the developmental process of atherosclerosis. Zhang F, et al. FASEB J, 2024 Mar 31. PMID 38498343
  2. Tousled-like kinase 1 promotes gastric cancer progression by regulating the tumor growth factor-beta signaling pathway. Sun RC, et al. World J Gastroenterol, 2023 Nov 28. PMID 38111505, Free PMC Article
  3. The circular RNA TLK1 exacerbates myocardial ischemia/reperfusion injury via targeting miR-214/RIPK1 through TNF signaling pathway. Song YF, et al. Free Radic Biol Med, 2020 Aug 1. PMID 32445866
  4. Tousled-like kinase 1 is a negative regulator of core transcription factors in murine embryonic stem cells. Lee J, et al. Sci Rep, 2018 Jan 10. PMID 29321513, Free PMC Article
  5. The radioresistance kinase TLK1B protects the cells by promoting repair of double strand breaks. Sunavala-Dossabhoy G, et al. BMC Mol Biol, 2005 Sep 12. PMID 16156902, Free PMC Article

See all (34) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. CircTLK1: A novel regulator involved in VSMC phenotypic switching and the developmental process of atherosclerosis.
    Title: CircTLK1: A novel regulator involved in VSMC phenotypic switching and the developmental process of atherosclerosis.
  2. Tousled-like kinase 1 promotes gastric cancer progression by regulating the tumor growth factor-beta signaling pathway.
    Title: Tousled-like kinase 1 promotes gastric cancer progression by regulating the tumor growth factor-beta signaling pathway.
  3. CircTLK1 alleviates oxygen-glucose deprivation/reperfusion induced apoptosis in HK-2 cells through miR-136-5p/Bcl2 signal axis.
    Title: CircTLK1 alleviates oxygen-glucose deprivation/reperfusion induced apoptosis in HK-2 cells through miR-136-5p/Bcl2 signal axis.
  4. The circular RNA TLK1 exacerbates myocardial ischemia/reperfusion injury via targeting miR-214/RIPK1 through TNF signaling pathway.
    Title: The circular RNA TLK1 exacerbates myocardial ischemia/reperfusion injury via targeting miR-214/RIPK1 through TNF signaling pathway.
  5. our data suggest that Tlk1 negatively regulates the expression of pluripotency factors, thereby contributing to the scheduled differentiation of mouse ESCs.
    Title: Tousled-like kinase 1 is a negative regulator of core transcription factors in murine embryonic stem cells.
  6. TLK1 and TLK2 have largely redundant roles in genome maintenance.
    Title: Differential requirements for Tousled-like kinases 1 and 2 in mammalian development.
  7. present direct evidence that TLK1B can promote repair of linearized plasmids with incompatible ends that require processing prior to ligation.
    Title: TLK1B promotes repair of DSBs via its interaction with Rad9 and Asf1.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Gene trapped (2) 
  • Targeted (4)  1 citation

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables 3-phosphoinositide-dependent protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables AMP-activated protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables ATP binding ISO
Inferred from Sequence Orthology
more info
  
enables ATP binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables DNA-dependent protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables Rho-dependent protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables eukaryotic translation initiation factor 2alpha kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H2AS1 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H2AS121 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H2AT120 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H2AXS139 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H2BS14 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H2BS36 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H3S10 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H3S28 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H3S57 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H3T11 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H3T3 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H3T45 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H3T6 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H4S1 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein serine/threonine kinase activity ISO
Inferred from Sequence Orthology
more info
  
enables protein serine/threonine kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables ribosomal protein S6 kinase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in DNA damage response IEA
Inferred from Electronic Annotation
more info
  
involved_in chromatin remodeling IEA
Inferred from Electronic Annotation
more info
  
involved_in chromosome segregation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in intracellular protein transport IEA
Inferred from Electronic Annotation
more info
  
involved_in intracellular protein transport ISO
Inferred from Sequence Orthology
more info
  
involved_in intracellular signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in intracellular signal transduction ISO
Inferred from Sequence Orthology
more info
  
involved_in intracellular signal transduction ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in protein phosphorylation ISO
Inferred from Sequence Orthology
more info
  
involved_in protein phosphorylation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of chromatin organization ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of chromatin organization ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
serine/threonine-protein kinase tousled-like 1
NP_001349892.1
NP_766252.2
XP_006499251.1
XP_006499252.1
XP_006499254.1
XP_006499256.1
XP_017173069.1
XP_017173070.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001362963.1 → NP_001349892.1  serine/threonine-protein kinase tousled-like 1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL928868, BX000490
    Conserved Domains (1) summary
    cd14040
    Location:401 → 699
    STKc_TLK1; Catalytic domain of the Serine/Threonine kinase, Tousled-Like Kinase 1

  2. NM_172664.3 → NP_766252.2  serine/threonine-protein kinase tousled-like 1 isoform 1

    See identical proteins and their annotated locations for NP_766252.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    BC051641
    Consensus CDS
    CCDS50599.1
    UniProtKB/Swiss-Prot
    Q8C0V0
    Related
    ENSMUSP00000035961.9, ENSMUST00000038584.9
    Conserved Domains (2) summary
    smart00220
    Location:467 → 734
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14040
    Location:449 → 747
    STKc_TLK1; Catalytic domain of the Serine/Threonine kinase, Tousled-Like Kinase 1

RNA

  1. NR_156420.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL928868, BC057369, BX000490
    Related
    ENSMUST00000135128.8

  2. NR_156421.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AK045308, BX000490
    Related
    ENSMUST00000124629.2

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    70542751..70656505 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006499193.2 → XP_006499256.1  serine/threonine-protein kinase tousled-like 1 isoform X3

    See identical proteins and their annotated locations for XP_006499256.1

    UniProtKB/TrEMBL
    Q6A0C1
    Conserved Domains (1) summary
    cd14040
    Location:232 → 530
    STKc_TLK1; Catalytic domain of the Serine/Threonine kinase, Tousled-Like Kinase 1

  2. XM_006499189.4 → XP_006499252.1  serine/threonine-protein kinase tousled-like 1 isoform X2

    Conserved Domains (1) summary
    cl21453
    Location:449 → 711
    PKc_like; Protein Kinases, catalytic domain

  3. XM_006499191.3 → XP_006499254.1  serine/threonine-protein kinase tousled-like 1 isoform X3

    See identical proteins and their annotated locations for XP_006499254.1

    UniProtKB/TrEMBL
    Q6A0C1
    Conserved Domains (1) summary
    cd14040
    Location:232 → 530
    STKc_TLK1; Catalytic domain of the Serine/Threonine kinase, Tousled-Like Kinase 1

  4. XM_006499188.5 → XP_006499251.1  serine/threonine-protein kinase tousled-like 1 isoform X1

    See identical proteins and their annotated locations for XP_006499251.1

    Conserved Domains (1) summary
    cd14040
    Location:417 → 715
    STKc_TLK1; Catalytic domain of the Serine/Threonine kinase, Tousled-Like Kinase 1

  5. XM_017317581.1 → XP_017173070.1  serine/threonine-protein kinase tousled-like 1 isoform X3

    UniProtKB/TrEMBL
    Q6A0C1
    Conserved Domains (1) summary
    cd14040
    Location:232 → 530
    STKc_TLK1; Catalytic domain of the Serine/Threonine kinase, Tousled-Like Kinase 1

  6. XM_017317580.3 → XP_017173069.1  serine/threonine-protein kinase tousled-like 1 isoform X3

    UniProtKB/TrEMBL
    Q6A0C1
    Conserved Domains (1) summary
    cd14040
    Location:232 → 530
    STKc_TLK1; Catalytic domain of the Serine/Threonine kinase, Tousled-Like Kinase 1

RNA

  1. XR_003952263.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8C0V0.2 GenPept UniProtKB/Swiss-Prot:Q8C0V0

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