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Ikzf4 IKAROS family zinc finger 4 [ Mus musculus (house mouse) ]

Gene ID: 22781, updated on 27-Nov-2024

Summary

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Official Symbol
Ikzf4provided by MGI
Official Full Name
IKAROS family zinc finger 4provided by MGI
Primary source
MGI:MGI:1343139
See related
Ensembl:ENSMUSG00000002578 AllianceGenome:MGI:1343139
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Eos; Zfpn1a4; Znfn1a4; A630026H08Rik
Summary
Enables bHLH transcription factor binding activity and sequence-specific DNA binding activity. Acts upstream of or within negative regulation of DNA-templated transcription and positive regulation of transcription by RNA polymerase II. Predicted to be located in nuclear body. Predicted to be part of protein-containing complex. Is expressed in several structures, including central nervous system; dorsal root ganglion; genitourinary system; hemolymphoid system; and retina. Used to study encephalomyelitis. Orthologous to human IKZF4 (IKAROS family zinc finger 4). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Broad expression in whole brain E14.5 (RPKM 4.1), CNS E14 (RPKM 4.1) and 24 other tissues See more
Orthologs
human all
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Genomic context

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See Ikzf4 in Genome Data Viewer
Location:
10 D3; 10 77.11 cM
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (128466708..128505668, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (128630839..128669671, complement)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E5200 Neighboring gene predicted gene 9182 Neighboring gene STARR-positive B cell enhancer ABC_E904 Neighboring gene ribosomal protein S26 Neighboring gene predicted gene, 26876 Neighboring gene predicted gene, 51824 Neighboring gene STARR-positive B cell enhancer ABC_E2343 Neighboring gene sulfite oxidase Neighboring gene ribosomal protein L12 pseudogene Neighboring gene RAB5B, member RAS oncogene family

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. CD4(+) regulatory T cells lacking Helios and Eos. Polak K, et al. Biochem Biophys Res Commun, 2023 Sep 24. PMID 37413709
  2. Selective deletion of Eos (Ikzf4) in T-regulatory cells leads to loss of suppressive function and development of systemic autoimmunity. Gokhale AS, et al. J Autoimmun, 2019 Dec. PMID 31296356, Free PMC Article
  3. Regulation of gene expression dynamics during developmental transitions by the Ikaros transcription factor. Arenzana TL, et al. Genes Dev, 2015 Sep 1. PMID 26314708, Free PMC Article
  4. Cytotoxic Programming of CD4+ T Cells Is Regulated by Opposing Actions of the Related Transcription Factors Eos and Aiolos. Jones DM, et al. J Immunol, 2024 Apr 1. PMID 38363226,
  5. Eos, MITF, and PU.1 recruit corepressors to osteoclast-specific genes in committed myeloid progenitors. Hu R, et al. Mol Cell Biol, 2007 Jun. PMID 17403896, Free PMC Article

See all (39) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Cytotoxic Programming of CD4+ T Cells Is Regulated by Opposing Actions of the Related Transcription Factors Eos and Aiolos.
    Title: Cytotoxic Programming of CD4+ T Cells Is Regulated by Opposing Actions of the Related Transcription Factors Eos and Aiolos.
  2. CD4[+] regulatory T cells lacking Helios and Eos.
    Title: CD4(+) regulatory T cells lacking Helios and Eos.
  3. Eos (lkzf4) appears to play an essential role in multiple aspects of Treg suppressor function.
    Title: Selective deletion of Eos (Ikzf4) in T-regulatory cells leads to loss of suppressive function and development of systemic autoimmunity.
  4. this study reports that IL-6 actively suppressed Eos mRNA and protein expression through miR-17
    Title: MicroRNA-17 Modulates Regulatory T Cell Function by Targeting Co-regulators of the Foxp3 Transcription Factor.
  5. Ikaros may not be a conventional activator or repressor of defined sets of genes, but may sharpen the dynamic range of gene expression changes during developmental transitions
    Title: Regulation of gene expression dynamics during developmental transitions by the Ikaros transcription factor.
  6. Eos is redundant for regulatory T cell function but plays an important role in IL-2 and IL-17 production by CD4+ conventional T cells.
    Title: Eos Is Redundant for Regulatory T Cell Function but Plays an Important Role in IL-2 and Th17 Production by CD4+ Conventional T Cells.
  7. Data indicate that miR-17 promotes TH17 differentiation by repressing target Ikaros Family Zinc Finger 4 (IKZF4).
    Title: miR-17-92 cluster targets phosphatase and tensin homology and Ikaros Family Zinc Finger 4 to promote TH17-mediated inflammation.
  8. We show that reprogramming is controlled by downregulation of the transcription factor Eos (Ikzf4), an obligate corepressor for Foxp3.
    Title: An inherently bifunctional subset of Foxp3+ T helper cells is controlled by the transcription factor eos.
  9. study identified Eos as a critical mediator of Foxp3-dependent gene silencing in CD4+ regulatory T cells (Tregs); Eos interacts directly with Foxp3 and induces chromatin modifications that result in gene silencing in Tregs
    Title: Eos mediates Foxp3-dependent gene silencing in CD4+ regulatory T cells.
  10. Data suggest that Eos, MITF, and PU.1 recruit corepressors to osteoclast-specific genes in committed myeloid progenitor cells.
    Title: Eos, MITF, and PU.1 recruit corepressors to osteoclast-specific genes in committed myeloid progenitors.
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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 
  • Targeted (3)  1 citation

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA-binding transcription factor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables bHLH transcription factor binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein domain specific binding IEA
Inferred from Electronic Annotation
more info
  
enables protein domain specific binding ISO
Inferred from Sequence Orthology
more info
  
enables sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within negative regulation of DNA-templated transcription IPI
Inferred from Physical Interaction
more info
 PubMed 
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein homooligomerization IEA
Inferred from Electronic Annotation
more info
  
involved_in protein homooligomerization ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in nuclear body IEA
Inferred from Electronic Annotation
more info
  
located_in nuclear body ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
part_of protein-containing complex IEA
Inferred from Electronic Annotation
more info
  
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
zinc finger protein Eos
Names
ikaros family zinc finger protein 4
zinc finger protein, subfamily 1A, 4 (Eos)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001358536.2 → NP_001345465.1  zinc finger protein Eos isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2), as well as variant 3, encodes isoform 2.
    Source sequence(s)
    AC117232
    Conserved Domains (3) summary
    COG5189
    Location:156 → 216
    SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
    sd00017
    Location:106 → 126
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:146 → 171
    zf-H2C2_2; Zinc-finger double domain

  2. NM_001358537.2 → NP_001345466.1  zinc finger protein Eos isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC117232
    Conserved Domains (3) summary
    COG5189
    Location:156 → 216
    SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
    sd00017
    Location:106 → 126
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:146 → 171
    zf-H2C2_2; Zinc-finger double domain

  3. NM_001428880.1 → NP_001415809.1  zinc finger protein Eos isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4), as well as variant 5, encodes isoform 3.
    Source sequence(s)
    AC117232

  4. NM_001428881.1 → NP_001415810.1  zinc finger protein Eos isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC117232

  5. NM_001428882.1 → NP_001415811.1  zinc finger protein Eos isoform 4

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6), as well as variant 7, encodes isoform 4.
    Source sequence(s)
    AC117232
    UniProtKB/TrEMBL
    A0A571BEH5

  6. NM_001428883.1 → NP_001415812.1  zinc finger protein Eos isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC117232
    UniProtKB/TrEMBL
    A0A571BEH5

  7. NM_001428884.1 → NP_001415813.1  zinc finger protein Eos isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC117232

  8. NM_011772.4 → NP_035902.2  zinc finger protein Eos isoform 1

    See identical proteins and their annotated locations for NP_035902.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AC117232
    Consensus CDS
    CCDS24284.2
    UniProtKB/Swiss-Prot
    B9EJ21, Q3TCZ7, Q8C208, Q9Z2Z2
    Related
    ENSMUSP00000114404.2, ENSMUST00000133342.10
    Conserved Domains (2) summary
    sd00017
    Location:161 → 181
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:201 → 226
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    128466708..128505668 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036155766.1 → XP_036011659.1  zinc finger protein Eos isoform X1

    Conserved Domains (3) summary
    COG5189
    Location:208 → 268
    SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
    sd00017
    Location:158 → 178
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:198 → 223
    zf-H2C2_2; Zinc-finger double domain

  2. XM_006513612.2 → XP_006513675.1  zinc finger protein Eos isoform X2

    Conserved Domains (3) summary
    COG5189
    Location:166 → 226
    SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
    sd00017
    Location:116 → 136
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:156 → 181
    zf-H2C2_2; Zinc-finger double domain

  3. XM_030245075.1 → XP_030100935.1  zinc finger protein Eos isoform X2

    Conserved Domains (3) summary
    COG5189
    Location:166 → 226
    SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
    sd00017
    Location:116 → 136
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:156 → 181
    zf-H2C2_2; Zinc-finger double domain

  4. XM_011243440.1 → XP_011241742.1  zinc finger protein Eos isoform X2

    See identical proteins and their annotated locations for XP_011241742.1

    Conserved Domains (3) summary
    COG5189
    Location:166 → 226
    SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
    sd00017
    Location:116 → 136
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:156 → 181
    zf-H2C2_2; Zinc-finger double domain

  5. XM_006513613.5 → XP_006513676.1  zinc finger protein Eos isoform X3

    Related
    ENSMUSP00000158702.2, ENSMUST00000238610.2
    Conserved Domains (3) summary
    COG5189
    Location:164 → 224
    SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
    sd00017
    Location:114 → 134
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:154 → 179
    zf-H2C2_2; Zinc-finger double domain

  6. XM_030245076.2 → XP_030100936.1  zinc finger protein Eos isoform X2

    Conserved Domains (3) summary
    COG5189
    Location:166 → 226
    SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
    sd00017
    Location:116 → 136
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:156 → 181
    zf-H2C2_2; Zinc-finger double domain

  7. XM_011243441.4 → XP_011241743.1  zinc finger protein Eos isoform X3

    Related
    ENSMUSP00000158614.2, ENSMUST00000238712.2
    Conserved Domains (3) summary
    COG5189
    Location:164 → 224
    SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
    sd00017
    Location:114 → 134
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:154 → 179
    zf-H2C2_2; Zinc-finger double domain

  8. XM_030245077.2 → XP_030100937.1  zinc finger protein Eos isoform X2

    Conserved Domains (3) summary
    COG5189
    Location:166 → 226
    SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
    sd00017
    Location:116 → 136
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:156 → 181
    zf-H2C2_2; Zinc-finger double domain

  9. XM_036155767.1 → XP_036011660.1  zinc finger protein Eos isoform X2

    Conserved Domains (3) summary
    COG5189
    Location:166 → 226
    SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
    sd00017
    Location:116 → 136
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:156 → 181
    zf-H2C2_2; Zinc-finger double domain

  10. XM_036155768.1 → XP_036011661.1  zinc finger protein Eos isoform X3

    UniProtKB/TrEMBL
    A0A571BEH5
    Conserved Domains (3) summary
    COG5189
    Location:164 → 224
    SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
    sd00017
    Location:114 → 134
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:154 → 179
    zf-H2C2_2; Zinc-finger double domain

  11. XM_006513616.4 → XP_006513679.1  zinc finger protein Eos isoform X5

    Conserved Domains (3) summary
    COG5189
    Location:109 → 169
    SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
    sd00017
    Location:59 → 79
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:99 → 124
    zf-H2C2_2; Zinc-finger double domain

  12. XM_030245078.2 → XP_030100938.1  zinc finger protein Eos isoform X4

    Related
    ENSMUSP00000152234.2, ENSMUST00000222067.2
    Conserved Domains (3) summary
    COG5189
    Location:156 → 216
    SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
    sd00017
    Location:106 → 126
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:146 → 171
    zf-H2C2_2; Zinc-finger double domain

  13. XM_030245074.2 → XP_030100934.1  zinc finger protein Eos isoform X2

    Conserved Domains (3) summary
    COG5189
    Location:166 → 226
    SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
    sd00017
    Location:116 → 136
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:156 → 181
    zf-H2C2_2; Zinc-finger double domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8C208.2 GenPept UniProtKB/Swiss-Prot:Q8C208

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