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Sh3glb2 SH3-domain GRB2-like endophilin B2 [ Mus musculus (house mouse) ]

Gene ID: 227700, updated on 27-Nov-2024

Summary

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Official Symbol
Sh3glb2provided by MGI
Official Full Name
SH3-domain GRB2-like endophilin B2provided by MGI
Primary source
MGI:MGI:2385131
See related
Ensembl:ENSMUSG00000026860 AllianceGenome:MGI:2385131
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
SPAS-1
Summary
Predicted to enable identical protein binding activity. Predicted to be involved in membrane organization and postsynaptic neurotransmitter receptor internalization. Predicted to be located in cytosol and nucleoplasm. Predicted to be active in glutamatergic synapse; membrane; and postsynaptic endocytic zone. Is expressed in several structures, including central nervous system; dorsal root ganglion; eye; limb; and skeleton. Orthologous to human SH3GLB2 (SH3 domain containing GRB2 like, endophilin B2). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in cerebellum adult (RPKM 61.1), frontal lobe adult (RPKM 59.8) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Sh3glb2 in Genome Data Viewer
Location:
2 B; 2 21.6 cM
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (30234789..30249380, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (30344777..30359358, complement)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E7805 Neighboring gene nucleoporin 188 Neighboring gene dolichol kinase Neighboring gene predicted gene, 39780 Neighboring gene mitoguardin 2 Neighboring gene STARR-positive B cell enhancer ABC_E410 Neighboring gene dolichyl pyrophosphate phosphatase 1 Neighboring gene carnitine acetyltransferase

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Endophilin B2 facilitates endosome maturation in response to growth factor stimulation, autophagy induction, and influenza A virus infection. Serfass JM, et al. J Biol Chem, 2017 Jun 16. PMID 28455444, Free PMC Article
  2. SPAS-1 (stimulator of prostatic adenocarcinoma-specific T cells)/SH3GLB2: A prostate tumor antigen identified by CTLA-4 blockade. Fassò M, et al. Proc Natl Acad Sci U S A, 2008 Mar 4. PMID 18303116, Free PMC Article
  3. Bcl-2 family interaction with the mitochondrial morphogenesis machinery. Cleland MM, et al. Cell Death Differ, 2011 Feb. PMID 20671748, Free PMC Article
  4. Proteomic Analysis of the Spinophilin Interactome in Rodent Striatum Following Psychostimulant Sensitization. Watkins DS, et al. Proteomes, 2018 Dec 17. PMID 30562941, Free PMC Article
  5. Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. Okazaki N, et al. DNA Res, 2003 Aug 31. PMID 14621295

See all (22) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Data (including data from studies in knockout mice) suggest that Sh3glb2 regulates trafficking of endocytic vesicles and autophagosomes to late endosomes or lysosomes; despite having an intracellular localization and tissue distribution similar to endophilin B1, endophilin B2 is dispensable for mitochondrial apoptosis.
    Title: Endophilin B2 facilitates endosome maturation in response to growth factor stimulation, autophagy induction, and influenza A virus infection.
  2. the immunodominant SPAS-1 epitope SNC9-H(8) arose from a point mutation in one allele of the gene in transgenic adenocarcinoma of mouse prostate tumor cells
    Title: SPAS-1 (stimulator of prostatic adenocarcinoma-specific T cells)/SH3GLB2: A prostate tumor antigen identified by CTLA-4 blockade.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Gene trapped (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Clone Names

  • KIAA1848

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in membrane organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in postsynaptic neurotransmitter receptor internalization ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
is_active_in glutamatergic synapse ISO
Inferred from Sequence Orthology
more info
  
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in postsynaptic endocytic zone ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
endophilin-B2
Names
SH3 domain-containing GRB2-like protein B2
SH3-containing protein SH3GLB2
stimulator of prostatic adenocarcinoma-specific T-cells-1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001289709.1 → NP_001276638.1  endophilin-B2 isoform 1

    See identical proteins and their annotated locations for NP_001276638.1

    Status: VALIDATED

    Source sequence(s)
    AK152409, BY317126, BY651947, CB249880, CX216029, EF676083
    Consensus CDS
    CCDS71020.1
    UniProtKB/Swiss-Prot
    Q3TIQ1, Q3U2J4, Q3U824, Q8K140, Q8R3V5, Q91ZI7
    UniProtKB/TrEMBL
    B0LDS3
    Related
    ENSMUSP00000097788.5, ENSMUST00000100215.11
    Conserved Domains (2) summary
    cd07617
    Location:21 → 278
    BAR_Endophilin_B2; The Bin/Amphiphysin/Rvs (BAR) domain of Endophilin-B2
    cd11944
    Location:344 → 398
    SH3_Endophilin_B2; Src homology 3 domain of Endophilin-B2

  2. NM_001289710.1 → NP_001276639.1  endophilin-B2 isoform 3

    See identical proteins and their annotated locations for NP_001276639.1

    Status: VALIDATED

    Source sequence(s)
    AK152502, BY317126, BY651947, CX216029
    Consensus CDS
    CCDS71018.1
    UniProtKB/TrEMBL
    A2AWI9, B0LDS3
    Related
    ENSMUSP00000109250.4, ENSMUST00000113620.10
    Conserved Domains (2) summary
    cd07617
    Location:21 → 257
    BAR_Endophilin_B2; The Bin/Amphiphysin/Rvs (BAR) domain of Endophilin-B2
    cd11944
    Location:318 → 372
    SH3_Endophilin_B2; Src homology 3 domain of Endophilin-B2

  3. NM_001346806.2 → NP_001333735.1  endophilin-B2 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AL954388
    Consensus CDS
    CCDS84504.1
    UniProtKB/TrEMBL
    A2AWI7, B0LDS3
    Related
    ENSMUSP00000109251.4, ENSMUST00000113621.10

  4. NM_001362888.1 → NP_001349817.1  endophilin-B2 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AL954388
    UniProtKB/TrEMBL
    B0LDS3
    Conserved Domains (2) summary
    cd07617
    Location:21 → 249
    BAR_Endophilin_B2; The Bin/Amphiphysin/Rvs (BAR) domain of Endophilin-B2
    cd11944
    Location:310 → 364
    SH3_Endophilin_B2; Src homology 3 domain of Endophilin-B2

  5. NM_139302.2 → NP_647463.1  endophilin-B2 isoform 2

    See identical proteins and their annotated locations for NP_647463.1

    Status: VALIDATED

    Source sequence(s)
    AK152409, BY317126, BY651947, CX216029, EF676083
    Consensus CDS
    CCDS15879.1
    UniProtKB/TrEMBL
    B0LDS3
    Related
    ENSMUSP00000028214.9, ENSMUST00000028214.15
    Conserved Domains (2) summary
    cd07617
    Location:21 → 278
    BAR_Endophilin_B2; The Bin/Amphiphysin/Rvs (BAR) domain of Endophilin-B2
    cd11944
    Location:339 → 393
    SH3_Endophilin_B2; Src homology 3 domain of Endophilin-B2

RNA

  1. NR_156413.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL954388

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    30234789..30249380 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036160832.1 → XP_036016725.1  endophilin-B2 isoform X8

    Conserved Domains (2) summary
    cd11944
    Location:247 → 301
    SH3_Endophilin_B2; Src homology 3 domain of Endophilin-B2
    cl12013
    Location:1 → 181
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

  2. XM_036160841.1 → XP_036016734.1  endophilin-B2 isoform X11

    Conserved Domains (1) summary
    cl12013
    Location:1 → 181
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

  3. XM_006497939.2 → XP_006498002.1  endophilin-B2 isoform X3

    UniProtKB/TrEMBL
    B0LDS3
    Related
    ENSMUSP00000131545.3, ENSMUST00000163668.3
    Conserved Domains (2) summary
    cd07617
    Location:21 → 257
    BAR_Endophilin_B2; The Bin/Amphiphysin/Rvs (BAR) domain of Endophilin-B2
    cd11944
    Location:323 → 377
    SH3_Endophilin_B2; Src homology 3 domain of Endophilin-B2

  4. XM_030249870.1 → XP_030105730.1  endophilin-B2 isoform X6

    Conserved Domains (1) summary
    cd07617
    Location:21 → 278
    BAR_Endophilin_B2; The Bin/Amphiphysin/Rvs (BAR) domain of Endophilin-B2

  5. XM_006497938.2 → XP_006498001.1  endophilin-B2 isoform X2

    UniProtKB/TrEMBL
    B0LDS3
    Conserved Domains (2) summary
    cd07617
    Location:21 → 261
    BAR_Endophilin_B2; The Bin/Amphiphysin/Rvs (BAR) domain of Endophilin-B2
    cd11944
    Location:327 → 381
    SH3_Endophilin_B2; Src homology 3 domain of Endophilin-B2

  6. XM_006497937.2 → XP_006498000.1  endophilin-B2 isoform X1

    UniProtKB/TrEMBL
    B0LDS3
    Conserved Domains (2) summary
    cd07617
    Location:21 → 282
    BAR_Endophilin_B2; The Bin/Amphiphysin/Rvs (BAR) domain of Endophilin-B2
    cd11944
    Location:343 → 397
    SH3_Endophilin_B2; Src homology 3 domain of Endophilin-B2

  7. XM_011239078.2 → XP_011237380.1  endophilin-B2 isoform X5

    Conserved Domains (1) summary
    cd07617
    Location:21 → 282
    BAR_Endophilin_B2; The Bin/Amphiphysin/Rvs (BAR) domain of Endophilin-B2

  8. XM_011239077.2 → XP_011237379.1  endophilin-B2 isoform X4

    Conserved Domains (1) summary
    cd07617
    Location:21 → 282
    BAR_Endophilin_B2; The Bin/Amphiphysin/Rvs (BAR) domain of Endophilin-B2

  9. XM_006497941.5 → XP_006498004.1  endophilin-B2 isoform X7

    See identical proteins and their annotated locations for XP_006498004.1

    Conserved Domains (2) summary
    cd11944
    Location:251 → 305
    SH3_Endophilin_B2; Src homology 3 domain of Endophilin-B2
    cl12013
    Location:1 → 185
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

  10. XM_030249882.1 → XP_030105742.1  endophilin-B2 isoform X10

    Conserved Domains (2) summary
    cd11944
    Location:226 → 280
    SH3_Endophilin_B2; Src homology 3 domain of Endophilin-B2
    cl12013
    Location:1 → 160
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

  11. XM_030249878.1 → XP_030105738.1  endophilin-B2 isoform X9

    Conserved Domains (2) summary
    cd11944
    Location:242 → 296
    SH3_Endophilin_B2; Src homology 3 domain of Endophilin-B2
    cl12013
    Location:1 → 181
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

  12. XM_006497942.4 → XP_006498005.1  endophilin-B2 isoform X7

    See identical proteins and their annotated locations for XP_006498005.1

    Conserved Domains (2) summary
    cd11944
    Location:251 → 305
    SH3_Endophilin_B2; Src homology 3 domain of Endophilin-B2
    cl12013
    Location:1 → 185
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

  13. XM_036160844.1 → XP_036016737.1  endophilin-B2 isoform X13

    Conserved Domains (2) summary
    cd11944
    Location:159 → 213
    SH3_Endophilin_B2; Src homology 3 domain of Endophilin-B2
    cl12013
    Location:36 → 98
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

  14. XM_036160842.1 → XP_036016735.1  endophilin-B2 isoform X12

    Conserved Domains (2) summary
    cd11944
    Location:164 → 218
    SH3_Endophilin_B2; Src homology 3 domain of Endophilin-B2
    cl12013
    Location:36 → 98
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

  15. XM_030249884.1 → XP_030105744.1  endophilin-B2 isoform X12

    Conserved Domains (2) summary
    cd11944
    Location:164 → 218
    SH3_Endophilin_B2; Src homology 3 domain of Endophilin-B2
    cl12013
    Location:36 → 98
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

RNA

  1. XR_004939601.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8R3V5.2 GenPept UniProtKB/Swiss-Prot:Q8R3V5

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