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Man1b1 mannosidase, alpha, class 1B, member 1 [ Mus musculus (house mouse) ]

Gene ID: 227619, updated on 27-Nov-2024

Summary

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Official Symbol
Man1b1provided by MGI
Official Full Name
mannosidase, alpha, class 1B, member 1provided by MGI
Primary source
MGI:MGI:2684954
See related
Ensembl:ENSMUSG00000036646 AllianceGenome:MGI:2684954
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Gm108; ERMan1; MANA-ER; E430019H13Rik
Summary
Enables mannosyl-oligosaccharide 1,2-alpha-mannosidase activity. Acts upstream of or within ERAD pathway. Predicted to be located in cytoplasmic vesicle and endoplasmic reticulum quality control compartment. Predicted to be active in endoplasmic reticulum and membrane. Human ortholog(s) of this gene implicated in Rafiq syndrome. Orthologous to human MAN1B1 (mannosidase alpha class 1B member 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in large intestine adult (RPKM 13.7), limb E14.5 (RPKM 11.4) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Man1b1 in Genome Data Viewer
Location:
2 A3; 2 17.17 cM
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (25222742..25242225)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (25332730..25352213)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene glutamate receptor, ionotropic, NMDA1 (zeta 1), opposite strand Neighboring gene glutamate receptor, ionotropic, NMDA1 (zeta 1) Neighboring gene STARR-seq mESC enhancer starr_03964 Neighboring gene STARR-seq mESC enhancer starr_03965 Neighboring gene expressed sequence AA543186 Neighboring gene dipeptidylpeptidase 7 Neighboring gene predicted gene, 46732

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Endoplasmic reticulum-associated degradation-induced dissociation of class II invariant chain complexes containing a glycosylation-deficient form of p41. Sevilla LM, et al. J Immunol, 2004 Aug 15. PMID 15294975
  2. Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method. Piao Y, et al. Genome Res, 2001 Sep. PMID 11544199, Free PMC Article
  3. Irisin Mediates Effects on Bone and Fat via αV Integrin Receptors. Kim H, et al. Cell, 2018 Dec 13. PMID 30550785, Free PMC Article
  4. Fancd2 in vivo interaction network reveals a non-canonical role in mitochondrial function. Zhang T, et al. Sci Rep, 2017 Apr 5. PMID 28378742, Free PMC Article
  5. GenePaint.org: an atlas of gene expression patterns in the mouse embryo. Visel A, et al. Nucleic Acids Res, 2004 Jan 1. PMID 14681479, Free PMC Article

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
  
enables mannosyl-oligosaccharide 1,2-alpha-mannosidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables mannosyl-oligosaccharide 1,2-alpha-mannosidase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables mannosyl-oligosaccharide 1,2-alpha-mannosidase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in ERAD pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within ERAD pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in ERAD pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in carbohydrate metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in mannoprotein catabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in mannoprotein catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in protein glycosylation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasmic vesicle ISO
Inferred from Sequence Orthology
more info
  
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
  
located_in endoplasmic reticulum quality control compartment IEA
Inferred from Electronic Annotation
more info
  
located_in endoplasmic reticulum quality control compartment ISO
Inferred from Sequence Orthology
more info
  
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase
Names
ER alpha-1,2-mannosidase
ER mannosidase 1
man9GlcNAc2-specific-processing alpha-mannosidase
NP_001025154.1
XP_006497923.1
XP_030105470.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001029983.2 → NP_001025154.1  endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase

    See identical proteins and their annotated locations for NP_001025154.1

    Status: VALIDATED

    Source sequence(s)
    AL732557, BC138551, BQ129775, BY247979, BY732333
    Consensus CDS
    CCDS15765.1
    UniProtKB/Swiss-Prot
    A2AJ15
    UniProtKB/TrEMBL
    Q923C1
    Related
    ENSMUSP00000036996.5, ENSMUST00000042390.5
    Conserved Domains (1) summary
    pfam01532
    Location:215 → 654
    Glyco_hydro_47; Glycosyl hydrolase family 47

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    25222742..25242225
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006497860.2 → XP_006497923.1  endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase isoform X1

    Conserved Domains (1) summary
    pfam01532
    Location:215 → 549
    Glyco_hydro_47; Glycosyl hydrolase family 47

  2. XM_030249610.2 → XP_030105470.1  endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase isoform X2

    UniProtKB/TrEMBL
    Q8BTW7
    Conserved Domains (1) summary
    pfam01532
    Location:1 → 398
    Glyco_hydro_47; Glycosyl hydrolase family 47
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A2AJ15.1 GenPept UniProtKB/Swiss-Prot:A2AJ15

Gene LinkOut

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