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Zfp125 zinc finger protein 125 [ Mus musculus (house mouse) ]

Gene ID: 22651, updated on 4-Jan-2025

Summary

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Official Symbol
Zfp125provided by MGI
Official Full Name
zinc finger protein 125provided by MGI
Primary source
MGI:MGI:1336211
See related
AllianceGenome:MGI:1336211
Gene type
protein coding
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
ZT2
Summary
Enables DNA-binding transcription repressor activity and chromatin DNA binding activity. Acts upstream of or within lipid metabolic process and negative regulation of DNA-templated transcription. Is expressed in several structures, including brain; gut; heart; metanephros; and skeletal muscle. [provided by Alliance of Genome Resources, Jan 2025]
Annotation information
not in current annotation release
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Genomic context

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Location:
12 8.28 cM

Bibliography

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Related articles in PubMed

  1. Isolation and characterization of the murine zinc finger coding gene, ZT2: expression in normal and transformed myogenic cells. Giorgi S, et al. Gene, 1999 Apr 1. PMID 10196477
  2. The Foxo1-Inducible Transcriptional Repressor Zfp125 Causes Hepatic Steatosis and Hypercholesterolemia. Fernandes GW, et al. Cell Rep, 2018 Jan 9. PMID 29320745, Free PMC Article
  3. Genetic dissection of the fatty liver QTL Fl1sa by using congenic mice and identification of candidate genes in the liver and epididymal fat. Suzuki M, et al. BMC Genet, 2016 Nov 17. PMID 27855657, Free PMC Article
  4. Mouse brain organization revealed through direct genome-scale TF expression analysis. Gray PA, et al. Science, 2004 Dec 24. PMID 15618518
  5. BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system. Magdaleno S, et al. PLoS Biol, 2006 Apr. PMID 16602821, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA-binding transcription repressor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables chromatin DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within lipid metabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within lipid metabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within lipid metabolic process ISO
Inferred from Sequence Orthology
more info
 PubMed 
acts_upstream_of_or_within negative regulation of DNA-templated transcription IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  

General protein information

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Preferred Names
zinc finger protein 125
Nucleotide Protein
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