Rin1 Ras and Rab interactor 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Rin1provided by MGI
Official Full Name: Ras and Rab interactor 1provided by MGI
Primary source: MGI:MGI:2385695
See related: Ensembl:ENSMUSG00000024883 AllianceGenome:MGI:2385695
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary: Enables small GTPase binding activity. Acts upstream of or within associative learning; memory; and negative regulation of synaptic plasticity. Located in dendrite and neuronal cell body. Is expressed in brain; gonad; and thyroid gland. Orthologous to human RIN1 (Ras and Rab interactor 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Broad expression in cortex adult (RPKM 9.2), frontal lobe adult (RPKM 9.0) and 21 other tissues See more
Orthologs: human all
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Genomic context

Location:: 19 A; 19 4.23 cM

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	19	NC_000085.7 (5100035..5107100)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	19	NC_000085.6 (5049999..5057071)

Chromosome 19 - NC_000085.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

BCR-ABL1 kinase activity is regulated by RIN1
Title: ABL fusion oncogene transformation and inhibitor sensitivity are mediated by the cellular regulator RIN1.
These results provide insight into regulated expression of Rin1, define a promoter useful in telencephalic neuron studies, and describe a novel REST site variant directing expression to mature neurons.
Title: Regulated expression of the Ras effector Rin1 in forebrain neurons.
This study provided evidence that Rin1 normally functions as a negative regulator of fear learning and memory (Rin1-/- mice have enhanced fear conditioning and diminished fear extinction).
Title: Fear learning and extinction are linked to neuronal plasticity through Rin1 signaling.
the EphA4 receptor is required for synaptic plasticity in the amygdala, raising the possibility that an underlying mechanism of Rin1 function in amygdala is to down-regulate EphA4 signaling by promoting its endocytosis.
Title: The Rab5 guanylate exchange factor Rin1 regulates endocytosis of the EphA4 receptor in mature excitatory neurons.
RIN1 is an ABL tyrosine kinase activator and a regulator of epithelial-cell adhesion and migration.
Title: RIN1 is an ABL tyrosine kinase activator and a regulator of epithelial-cell adhesion and migration.
Rin1 links histone ubiquitylation to gene silencing and X inactivation.
Title: Polycomb group proteins Ring1A/B link ubiquitylation of histone H2A to heritable gene silencing and X inactivation.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Targeted (3) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

BB264363 (e-PCR)
- UniSTS:209421

AW554636 (e-PCR)
- UniSTS:186141

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables GTPase activator activity	IEA Inferred from Electronic Annotation more info
enables guanyl-nucleotide exchange factor activity	IBA Inferred from Biological aspect of Ancestor more info
enables guanyl-nucleotide exchange factor activity	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables small GTPase binding	IBA Inferred from Biological aspect of Ancestor more info
enables small GTPase binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within associative learning	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in endocytosis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within memory	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of synaptic plasticity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	ISO Inferred from Sequence Orthology more info	PubMed
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in dendrite	IDA Inferred from Direct Assay more info	PubMed
is_active_in endocytic vesicle	IBA Inferred from Biological aspect of Ancestor more info
located_in neuronal cell body	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	ISO Inferred from Sequence Orthology more info	PubMed

General protein information

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Preferred Names: ras and Rab interactor 1

Names: ras interaction/interference protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001374051.1 → NP_001360980.1 ras and Rab interactor 1 isoform 1

Status: VALIDATED

Source sequence(s)

AC124502

UniProtKB/TrEMBL

A0A2C9F2A2

Related

ENSMUSP00000025818.8, ENSMUST00000025818.8

Conserved Domains (3) summary

smart00167
Location:489 → 607

VPS9; Domain present in VPS9

cd10393
Location:57 → 153

SH2_RIN1; Src homology 2 (SH2) domain found in Ras and Rab interactor 1 (RIN1)-like proteins

cl28922
Location:625 → 705

Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold
NM_001374052.1 → NP_001360981.1 ras and Rab interactor 1 isoform 3

Status: VALIDATED

Source sequence(s)

AC124502

Conserved Domains (3) summary

smart00167
Location:354 → 472

VPS9; Domain present in VPS9

cl15255
Location:1 → 18

SH2; Src homology 2 (SH2) domain

cl28922
Location:490 → 570

Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold
NM_001425043.1 → NP_001411972.1 ras and Rab interactor 1 isoform 3

Status: VALIDATED

Source sequence(s)

AC124502
NM_145495.3 → NP_663470.1 ras and Rab interactor 1 isoform 2

See identical proteins and their annotated locations for NP_663470.1

Status: VALIDATED

Source sequence(s)

AC124502

Consensus CDS

CCDS29447.1

UniProtKB/Swiss-Prot

Q921Q7

Related

ENSMUSP00000153189.2, ENSMUST00000225427.2

Conserved Domains (3) summary

smart00167
Location:478 → 596

VPS9; Domain present in VPS9

cd10393
Location:57 → 157

SH2_RIN1; Src homology 2 (SH2) domain found in Ras and Rab interactor 1 (RIN1)-like proteins

cl28922
Location:614 → 694

Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000085.7 Reference GRCm39 C57BL/6J

Range

5100035..5107100

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006531719.3 → XP_006531782.1 ras and Rab interactor 1 isoform X5

Conserved Domains (3) summary

smart00167
Location:343 → 461

VPS9; Domain present in VPS9

cl15255
Location:1 → 22

SH2; Src homology 2 (SH2) domain

cl28922
Location:479 → 559

Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold
XM_006531711.4 → XP_006531774.1 ras and Rab interactor 1 isoform X2

Conserved Domains (3) summary

smart00167
Location:409 → 527

VPS9; Domain present in VPS9

cl15255
Location:46 → 73

SH2; Src homology 2 (SH2) domain

cl28922
Location:545 → 625

Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold
XM_006531712.4 → XP_006531775.1 ras and Rab interactor 1 isoform X3

Conserved Domains (3) summary

smart00167
Location:398 → 516

VPS9; Domain present in VPS9

cl15255
Location:46 → 77

SH2; Src homology 2 (SH2) domain

cl28922
Location:534 → 614

Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold
XM_006531710.4 → XP_006531773.1 ras and Rab interactor 1 isoform X1

See identical proteins and their annotated locations for XP_006531773.1

Conserved Domains (3) summary

smart00167
Location:513 → 631

VPS9; Domain present in VPS9

cd10393
Location:81 → 177

SH2_RIN1; Src homology 2 (SH2) domain found in Ras and Rab interactor 1 (RIN1)-like proteins

cl28922
Location:649 → 729

Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold
XM_006531715.3 → XP_006531778.1 ras and Rab interactor 1 isoform X4

See identical proteins and their annotated locations for XP_006531778.1

Conserved Domains (3) summary

smart00167
Location:354 → 472

VPS9; Domain present in VPS9

cl15255
Location:1 → 18

SH2; Src homology 2 (SH2) domain

cl28922
Location:490 → 570

Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold
XM_036161525.1 → XP_036017418.1 ras and Rab interactor 1 isoform X4

Conserved Domains (3) summary

smart00167
Location:354 → 472

VPS9; Domain present in VPS9

cl15255
Location:1 → 18

SH2; Src homology 2 (SH2) domain

cl28922
Location:490 → 570

Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold
XM_006531716.2 → XP_006531779.1 ras and Rab interactor 1 isoform X4

See identical proteins and their annotated locations for XP_006531779.1

Conserved Domains (3) summary

smart00167
Location:354 → 472

VPS9; Domain present in VPS9

cl15255
Location:1 → 18

SH2; Src homology 2 (SH2) domain

cl28922
Location:490 → 570

Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold
XM_006531718.2 → XP_006531781.1 ras and Rab interactor 1 isoform X4

See identical proteins and their annotated locations for XP_006531781.1

Conserved Domains (3) summary

smart00167
Location:354 → 472

VPS9; Domain present in VPS9

cl15255
Location:1 → 18

SH2; Src homology 2 (SH2) domain

cl28922
Location:490 → 570

Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold
XM_006531714.2 → XP_006531777.1 ras and Rab interactor 1 isoform X4

See identical proteins and their annotated locations for XP_006531777.1

Conserved Domains (3) summary

smart00167
Location:354 → 472

VPS9; Domain present in VPS9

cl15255
Location:1 → 18

SH2; Src homology 2 (SH2) domain

cl28922
Location:490 → 570

Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold