Zfp472 zinc finger protein 472 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Zfp472provided by MGI
Official Full Name: zinc finger protein 472provided by MGI
Primary source: MGI:MGI:2385049
See related: Ensembl:ENSMUSG00000053600 AllianceGenome:MGI:2385049
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Krim1; KRIM-1; Krim-1A; Krim-1B
Summary: Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Is expressed in central nervous system; early conceptus; and genitourinary system. [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in CNS E11.5 (RPKM 2.4), bladder adult (RPKM 2.2) and 23 other tissues See more
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Genomic context

Location:: 17 B1; 17 17.98 cM

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	17	NC_000083.7 (33184805..33198185)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	17	NC_000083.6 (32965831..32979211)

Chromosome 17 - NC_000083.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

These results suggest that Mipu1 is a nuclear protein, which functions as a transcriptional repressor.
Title: Functional analysis of a novel KRAB/C2H2 zinc finger protein Mipu1.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: zinc finger protein 472

Names: KRAB box containing zinc finger protein; Krab box proteins interacting with myc 1; zin finger protein 472

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_153063.3 → NP_694703.2 zinc finger protein 472

Status: VALIDATED

Source sequence(s)

AK142395, BB652931, BQ885210

Consensus CDS

CCDS50062.1

UniProtKB/TrEMBL

B0V2W5

Related

ENSMUSP00000036514.8, ENSMUST00000039132.9

Conserved Domains (5) summary

smart00349
Location:10 → 50

KRAB; krueppel associated box

COG5048
Location:195 → 492

COG5048; FOG: Zn-finger [General function prediction only]

sd00017
Location:395 → 415

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam01352
Location:10 → 49

KRAB; KRAB box

pfam13465
Location:435 → 460

zf-H2C2_2; Zinc-finger double domain