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Ilrun inflammation and lipid regulator with UBA-like and NBR1-like domains [ Mus musculus (house mouse) ]

Gene ID: 224647, updated on 27-Nov-2024

Summary

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Official Symbol
Ilrunprovided by MGI
Official Full Name
inflammation and lipid regulator with UBA-like and NBR1-like domainsprovided by MGI
Primary source
MGI:MGI:106281
See related
Ensembl:ENSMUSG00000056692 AllianceGenome:MGI:106281
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
D17Wsu92e; C030010A15
Summary
Predicted to enable ubiquitin binding activity. Predicted to be involved in several processes, including negative regulation of cytokine production; negative regulation of defense response to virus; and negative regulation of protein localization to nucleus. Predicted to be located in centrosome; cytosol; and nuclear speck. Predicted to be active in phagophore assembly site. Is expressed in several structures, including alimentary system; eye; genitourinary system; integumental system; and nervous system. Orthologous to human ILRUN (inflammation and lipid regulator with UBA-like and NBR1-like domains). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in kidney adult (RPKM 61.3), liver adult (RPKM 60.3) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Ilrun in Genome Data Viewer
Location:
17 A3.3; 17 14.59 cM
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (27970206..28039516, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (27751232..27820542, complement)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene protein kinase C and casein kinase substrate in neurons 1 Neighboring gene STARR-seq mESC enhancer starr_42171 Neighboring gene SAM pointed domain containing ets transcription factor Neighboring gene ribosomal protein S2, pseudogene 9 Neighboring gene STARR-seq mESC enhancer starr_42174 Neighboring gene STARR-positive B cell enhancer ABC_E2475 Neighboring gene STARR-positive B cell enhancer ABC_E4198 Neighboring gene CapStarr-seq enhancer MGSCv37_chr17:27976840-27977098 Neighboring gene U1 small nuclear ribonucleoprotein C Neighboring gene bridge-like lipid transfer protein family member 3A

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Identification of a novel role for the immunomodulator ILRUN in the development of several T cell subsets in mice. Tribolet L, et al. Immunobiology, 2023 May. PMID 37031606
  2. ILRUN Promotes Atherosclerosis Through Lipid-Dependent and Lipid-Independent Factors. Bi X, et al. Arterioscler Thromb Vasc Biol, 2022 Sep. PMID 35861973, Free PMC Article
  3. ILRUN, a Human Plasma Lipid GWAS Locus, Regulates Lipoprotein Metabolism in Mice. Bi X, et al. Circ Res, 2020 Nov 6. PMID 32912065, Free PMC Article
  4. Genomic structure and chromosomal mapping of the mouse transcription factor TEF-5 (Tead3) gene. Jacquemin P, et al. Mamm Genome, 1999 Jun. PMID 10341100
  5. Gene expression in the developing mouse retina by EST sequencing and microarray analysis. Mu X, et al. Nucleic Acids Res, 2001 Dec 15. PMID 11812828, Free PMC Article

See all (27) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. ILRUN Promotes Atherosclerosis Through Lipid-Dependent and Lipid-Independent Factors.
    Title: ILRUN Promotes Atherosclerosis Through Lipid-Dependent and Lipid-Independent Factors.
  2. ILRUN, a Human Plasma Lipid GWAS Locus, Regulates Lipoprotein Metabolism in Mice.
    Title: ILRUN, a Human Plasma Lipid GWAS Locus, Regulates Lipoprotein Metabolism in Mice.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 
  • Gene trapped (1) 
  • Targeted (1) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ubiquitin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in innate immune response IEA
Inferred from Electronic Annotation
more info
  
involved_in macroautophagy IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of DNA binding ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of DNA binding ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in negative regulation of defense response to virus ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of defense response to virus ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in negative regulation of protein localization to nucleus ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of protein localization to nucleus ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in negative regulation of tumor necrosis factor production ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of tumor necrosis factor production ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in negative regulation of type I interferon production ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of type I interferon production ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in centrosome ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in nuclear speck ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in phagophore assembly site IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
protein ILRUN
Names
uncharacterized protein C6orf106 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001033279.3 → NP_001028451.2  protein ILRUN isoform 1

    See identical proteins and their annotated locations for NP_001028451.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AC131799, AK161603
    Consensus CDS
    CCDS28569.1
    UniProtKB/Swiss-Prot
    A2RT11, Q3TT38
    UniProtKB/TrEMBL
    B2KF52
    Related
    ENSMUSP00000110513.3, ENSMUST00000114863.10
    Conserved Domains (2) summary
    cd14349
    Location:23 → 64
    UBA_CF106; UBA-like domain found in uncharacterized protein C6orf106 and similar proteins
    cd14947
    Location:71 → 180
    NBR1_like; Functionally uncharacterized domain in neighbor of Brca1 Gene 1 and related proteins

  2. NM_001044719.2 → NP_001038184.1  protein ILRUN isoform 2

    See identical proteins and their annotated locations for NP_001038184.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
    Source sequence(s)
    AC131799, BC137573
    Consensus CDS
    CCDS37523.1
    UniProtKB/TrEMBL
    A0A3B2W3W9, B2KF54
    Related
    ENSMUSP00000110509.2, ENSMUST00000114859.9
    Conserved Domains (2) summary
    cd14349
    Location:23 → 64
    UBA_CF106; UBA-like domain found in uncharacterized protein C6orf106 and similar proteins
    cd14947
    Location:71 → 180
    NBR1_like; Functionally uncharacterized domain in neighbor of Brca1 Gene 1 and related proteins

  3. NM_001271511.1 → NP_001258440.1  protein ILRUN isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an alternate exon, which results in a frameshift, compared to variant 1. The encoded isoform (3) is shorter and has a distinct C-terminus, compared to variant 1.
    Source sequence(s)
    AC131799, AK161603, BY755073
    Consensus CDS
    CCDS89036.1
    UniProtKB/TrEMBL
    A0A3B2WCT9
    Related
    ENSMUSP00000156684.2, ENSMUST00000233508.2
    Conserved Domains (2) summary
    cd14349
    Location:23 → 64
    UBA_CF106; UBA-like domain found in uncharacterized protein C6orf106 and similar proteins
    cd14947
    Location:71 → 170
    NBR1_like; Functionally uncharacterized domain in neighbor of Brca1 Gene 1 and related proteins

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    27970206..28039516 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q3TT38.2 GenPept UniProtKB/Swiss-Prot:Q3TT38

Gene LinkOut

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