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Xlr3a X-linked lymphocyte-regulated 3A [ Mus musculus (house mouse) ]

Gene ID: 22445, updated on 27-Nov-2024

Summary

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Official Symbol
Xlr3aprovided by MGI
Official Full Name
X-linked lymphocyte-regulated 3Aprovided by MGI
Primary source
MGI:MGI:109506
See related
Ensembl:ENSMUSG00000057836 AllianceGenome:MGI:109506
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Xlr3
Summary
Predicted to be involved in meiotic cell cycle and spermatid development. Predicted to be active in synaptonemal complex. Is expressed in several structures, including blood; central nervous system; female reproductive system; sensory organ; and submandibular gland primordium. [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in placenta adult (RPKM 19.3), liver E18 (RPKM 4.2) and 6 other tissues See more
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Genomic context

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See Xlr3a in Genome Data Viewer
Location:
X A7.3; X 37.29 cM
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (72129899..72140701, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (73086293..73097095, complement)

Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene paraneoplastic antigen MA3 Neighboring gene X-linked lymphocyte-regulated 4A Neighboring gene X-linked lymphocyte-regulated 5A Neighboring gene PWWP domain containing 4A Neighboring gene PWWP domain containing 4B Neighboring gene X-linked lymphocyte-regulated 5B

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Sequence and expression of murine cDNAs encoding Xlr3a and Xlr3b, defining a new X-linked lymphocyte-regulated Xlr gene subfamily. Bergsagel PL, et al. Gene, 1994 Dec 15. PMID 7821804
  2. Xlr3b is a new imprinted candidate for X-linked parent-of-origin effects on cognitive function in mice. Davies W, et al. Nat Genet, 2005 Jun. PMID 15908950
  3. Identification of a cluster of X-linked imprinted genes in mice. Raefski AS, et al. Nat Genet, 2005 Jun. PMID 15908953
  4. Histone H3 lysine 9 methyltransferases, G9a and GLP are essential for cardiac morphogenesis. Inagawa M, et al. Mech Dev, 2013 Nov-Dec. PMID 23892084
  5. Cracking the egg: molecular dynamics and evolutionary aspects of the transition from the fully grown oocyte to embryo. Evsikov AV, et al. Genes Dev, 2006 Oct 1. PMID 17015433, Free PMC Article

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC102490, MGC130195, MGC130233, MGC156362, MGC156363

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in meiotic cell cycle IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in spermatid development IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in synaptonemal complex IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
X-linked lymphocyte-regulated protein 3A
Names
X-linked B-cell surface antigen 3a
X-linked lymphocyte regulated 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001110784.1 → NP_001104254.1  X-linked lymphocyte-regulated protein 3A

    See identical proteins and their annotated locations for NP_001104254.1

    Status: VALIDATED

    Source sequence(s)
    AW556788, BC107255, BQ885410, BX813330, CJ302076, DV662513
    Consensus CDS
    CCDS53092.1
    UniProtKB/Swiss-Prot
    Q61244, Q61806
    UniProtKB/TrEMBL
    Q99L59
    Related
    ENSMUSP00000074199.6, ENSMUST00000074619.6
    Conserved Domains (1) summary
    pfam04803
    Location:72 → 187
    Cor1; Cor1/Xlr/Xmr conserved region

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000086.8 Reference GRCm39 C57BL/6J

    Range
    72129899..72140701 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011247556.1 → XP_011245858.1  X-linked lymphocyte-regulated protein 3A isoform X1

    See identical proteins and their annotated locations for XP_011245858.1

    UniProtKB/Swiss-Prot
    Q60595, Q61244, Q61806
    UniProtKB/TrEMBL
    Q78PE0
    Related
    ENSMUSP00000110170.3, ENSMUST00000114524.9
    Conserved Domains (1) summary
    pfam04803
    Location:75 → 203
    Cor1; Cor1/Xlr/Xmr conserved region

  2. XM_011247557.1 → XP_011245859.1  X-linked lymphocyte-regulated protein 3A isoform X1

    See identical proteins and their annotated locations for XP_011245859.1

    UniProtKB/Swiss-Prot
    Q60595, Q61244, Q61806
    UniProtKB/TrEMBL
    Q78PE0
    Conserved Domains (1) summary
    pfam04803
    Location:75 → 203
    Cor1; Cor1/Xlr/Xmr conserved region

  3. XM_011247559.1 → XP_011245861.1  X-linked lymphocyte-regulated protein 3A isoform X3

    See identical proteins and their annotated locations for XP_011245861.1

    Conserved Domains (1) summary
    pfam04803
    Location:1 → 116
    Cor1; Cor1/Xlr/Xmr conserved region

  4. XM_011247558.3 → XP_011245860.1  X-linked lymphocyte-regulated protein 3A isoform X2

    See identical proteins and their annotated locations for XP_011245860.1

    Conserved Domains (1) summary
    pfam04803
    Location:75 → 179
    Cor1; Cor1/Xlr/Xmr conserved region

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_011726.1: Suppressed sequence

    Description
    NM_011726.1: This RefSeq was temporarily suppressed because currently there is not sufficient data to support this transcript.
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q60595.1 GenPept UniProtKB/Swiss-Prot:Q60595

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