Upk1b uroplakin 1B [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Upk1bprovided by MGI
Official Full Name: uroplakin 1Bprovided by MGI
Primary source: MGI:MGI:98912
See related: Ensembl:ENSMUSG00000049436 AllianceGenome:MGI:98912
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: UPIb; Upk1; Tspan20
Summary: Acts upstream of or within response to bacterium. Located in apical plasma membrane. Is active in apical plasma membrane urothelial plaque. Is expressed in genitourinary system; mesothelium; pharyngo-tympanic tube; pharynx epithelium; and skin. Orthologous to human UPK1B (uroplakin 1B). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in bladder adult (RPKM 393.9) and lung adult (RPKM 17.4) See more
Orthologs: human all
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Genomic context

Location:: 16 B4; 16 26.87 cM

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	16	NC_000082.7 (38593544..38620565, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	16	NC_000082.6 (38773182..38800203, complement)

Chromosome 16 - NC_000082.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Upk1b expression is critical for urothelial plaque stability, maturation, differentiation, and homeostasis of urothelium. Report CAKUT in Upk1b knockout mice.
Title: Uroplakin 1b is critical in urinary tract development and urothelial differentiation and homeostasis.
The despites a lower level of expression, UPIb maintain its plaque association in urothelial preneoplastic lesions.
Title: Expression and localization of four uroplakins in urothelial preneoplastic lesions.
structure of the major membrane protein complex from urinary bladder epithelial cells by cryoelectron crystallography
Title: Structure of the major membrane protein complex from urinary bladder epithelial cells by cryo-electron crystallography.
analysis of glycan structures of uroplakins Ia and Ib
Title: Distinct glycan structures of uroplakins Ia and Ib: structural basis for the selective binding of FimH adhesin to uroplakin Ia.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (5)
Targeted (3)

General gene information

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Markers

AI413235 (e-PCR)
- UniSTS:165999

Upk1b (e-PCR), detects polymorphism
- UniSTS:502675

Upk1b (e-PCR), detects polymorphism
- UniSTS:527017

Gene Ontology Provided by MGI

Process	Evidence Code	Pubs
involved_in epithelial cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in epithelial cell differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within response to bacterium	IEP Inferred from Expression Pattern more info	PubMed

Component	Evidence Code	Pubs
located_in apical plasma membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in apical plasma membrane urothelial plaque	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: uroplakin-1b

Names: UP1b; uroplakin Ib

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_178924.4 → NP_849255.2 uroplakin-1b

See identical proteins and their annotated locations for NP_849255.2

Status: VALIDATED

Source sequence(s)

AK053004, AK083101, AK086926, BB427704, D18653

Consensus CDS

CCDS28174.1

UniProtKB/Swiss-Prot

Q8C448, Q8K4M0, Q9Z2C6

Related

ENSMUSP00000052469.5, ENSMUST00000057767.6

Conserved Domains (1) summary

cd03156
Location:120 → 230

uroplakin_I_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), uroplakin_I_like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000082.7 Reference GRCm39 C57BL/6J

Range

38593544..38620565 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017316943.2 → XP_017172432.1 uroplakin-1b isoform X1

UniProtKB/Swiss-Prot

Q8C448, Q8K4M0, Q9Z2C6

Conserved Domains (1) summary

cd03156
Location:120 → 230

uroplakin_I_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), uroplakin_I_like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment ...