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Slc35a2 solute carrier family 35 (UDP-galactose transporter), member A2 [ Mus musculus (house mouse) ]

Gene ID: 22232, updated on 4-Jan-2025

Summary

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Official Symbol
Slc35a2provided by MGI
Official Full Name
solute carrier family 35 (UDP-galactose transporter), member A2provided by MGI
Primary source
MGI:MGI:1345297
See related
Ensembl:ENSMUSG00000031156 AllianceGenome:MGI:1345297
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
UGT; Had1; Sfc8; Had-1; Ugalt
Summary
Enables UDP-galactose transmembrane transporter activity. Acts upstream of or within UDP-galactose transmembrane transport. Is active in Golgi membrane. Is expressed in several structures, including genitourinary system; heart; liver; lung; and spleen. Human ortholog(s) of this gene implicated in congenital disorder of glycosylation type IIm. Orthologous to human SLC35A2 (solute carrier family 35 member A2). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Ubiquitous expression in colon adult (RPKM 48.8), adrenal adult (RPKM 22.5) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Slc35a2 in Genome Data Viewer
Location:
X A1.1; X 3.56 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (7750189..7760699)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (7883921..7894492)

Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_46674 Neighboring gene OTU domain containing 5 Neighboring gene STARR-positive B cell enhancer ABC_E11045 Neighboring gene proviral integration site 2 Neighboring gene STARR-positive B cell enhancer ABC_E7684 Neighboring gene polyglutamine binding protein 1 Neighboring gene translocase of inner mitochondrial membrane 17b

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Loss of Slc35a2 alters development of the mouse cerebral cortex. Elziny S, et al. Neurosci Lett, 2024 Jul 27. PMID 38909838
  2. Isolation and characterization of mouse FM3A cell mutants which are devoid of Newcastle disease virus receptors. Hara T, et al. J Virol, 1989 Jan. PMID 2535724, Free PMC Article
  3. Nucleotide sugar transporter SLC35A2 is involved in promoting hepatocellular carcinoma metastasis by regulating cellular glycosylation. Cheng H, et al. Cell Oncol (Dordr), 2023 Apr. PMID 36454514
  4. The UDP-galactose translocator gene is mapped to band Xp11.23-p11.22 containing the Wiskott-Aldrich syndrome locus. Hara T, et al. Somat Cell Mol Genet, 1993 Nov. PMID 8128316
  5. Point mutations identified in Lec8 Chinese hamster ovary glycosylation mutants that inactivate both the UDP-galactose and CMP-sialic acid transporters. Oelmann S, et al. J Biol Chem, 2001 Jul 13. PMID 11319223

See all (24) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Loss of Slc35a2 alters development of the mouse cerebral cortex.
    Title: Loss of Slc35a2 alters development of the mouse cerebral cortex.
  2. Nucleotide sugar transporter SLC35A2 is involved in promoting hepatocellular carcinoma metastasis by regulating cellular glycosylation.
    Title: Nucleotide sugar transporter SLC35A2 is involved in promoting hepatocellular carcinoma metastasis by regulating cellular glycosylation.
  3. DEHP exposure did not influence lipase activity, whereas it slightly enhanced UGT activity and exclusively increased CYP4A14 levels in pregnant and/or postpartum dams.
    Title: Differences in metabolite burden of di(2-ethylhexyl)phthalate in pregnant and postpartum dams and their offspring in relation to drug-metabolizing enzymes in mice.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables UDP-galactose transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables UDP-galactose transmembrane transporter activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables UDP-galactose transmembrane transporter activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables antiporter activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in UDP-galactose transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within UDP-galactose transmembrane transport IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within UDP-galactose transmembrane transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in UDP-galactose transmembrane transport ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
  
is_active_in Golgi membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in Golgi membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in Golgi membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in Golgi membrane ISO
Inferred from Sequence Orthology
more info
  
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
UDP-galactose translocator
Names
UDP-Gal-Tr
UDP-galactose transporter
mUGT1
solute carrier family (UDP-N-acetylglucosamine transporter), member 2
solute carrier family 35 (UDP-galactose transporter) member 2
solute carrier family 35 (UDP-galactose transporter), member 2
solute carrier family 35 member A2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001083937.2 → NP_001077406.1  UDP-galactose translocator isoform 2

    See identical proteins and their annotated locations for NP_001077406.1

    Status: VALIDATED

    Source sequence(s)
    AL671978
    Consensus CDS
    CCDS52987.1
    UniProtKB/Swiss-Prot
    Q9R0M8
    UniProtKB/TrEMBL
    Q3UIP1, Q9JIH0
    Related
    ENSMUSP00000111324.5, ENSMUST00000115660.12
    Conserved Domains (2) summary
    TIGR00803
    Location:114 → 338
    nst; UDP-galactose transporter
    pfam04142
    Location:31 → 339
    Nuc_sug_transp; Nucleotide-sugar transporter

  2. NM_001426060.1 → NP_001412989.1  UDP-galactose translocator isoform 3

    Status: VALIDATED

    Source sequence(s)
    AL671978

  3. NM_001426061.1 → NP_001412990.1  UDP-galactose translocator isoform 4

    Status: VALIDATED

    Source sequence(s)
    AL671978
    UniProtKB/TrEMBL
    A0A140LI17
    Related
    ENSMUSP00000146635.2, ENSMUST00000208397.2

  4. NM_001426062.1 → NP_001412991.1  UDP-galactose translocator isoform 5

    Status: VALIDATED

    Source sequence(s)
    AL671978
    UniProtKB/TrEMBL
    F6WZ30
    Related
    ENSMUSP00000120681.3, ENSMUST00000153620.3

  5. NM_001426063.1 → NP_001412992.1  UDP-galactose translocator isoform 6

    Status: VALIDATED

    Source sequence(s)
    AL671978
    UniProtKB/TrEMBL
    F6QH15
    Related
    ENSMUSP00000116270.2, ENSMUST00000123277.8

  6. NM_001426064.1 → NP_001412993.1  UDP-galactose translocator isoform 7

    Status: VALIDATED

    Source sequence(s)
    AL671978
    UniProtKB/TrEMBL
    F6QH15

  7. NM_001426065.1 → NP_001412994.1  UDP-galactose translocator isoform 8

    Status: VALIDATED

    Source sequence(s)
    AL671978
    UniProtKB/TrEMBL
    A0A140LIP5

  8. NM_078484.3 → NP_511039.2  UDP-galactose translocator isoform 1

    Status: VALIDATED

    Source sequence(s)
    AL671978
    Consensus CDS
    CCDS52986.1
    UniProtKB/TrEMBL
    A2AER4, Q9JIH0
    Related
    ENSMUSP00000111327.4, ENSMUST00000115663.10
    Conserved Domains (2) summary
    TIGR00803
    Location:114 → 338
    nst; UDP-galactose transporter
    pfam04142
    Location:31 → 339
    Nuc_sug_transp; Nucleotide-sugar transporter

RNA

  1. NR_189662.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL671978

  2. NR_189663.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL671978

  3. NR_189664.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL671978

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000086.8 Reference GRCm39 C57BL/6J

    Range
    7750189..7760699
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030251303.2 → XP_030107163.2  UDP-galactose translocator isoform X1

    Conserved Domains (1) summary
    pfam04142
    Location:1 → 267
    Nuc_sug_transp; Nucleotide-sugar transporter

  2. XM_006527584.4 → XP_006527647.1  UDP-galactose translocator isoform X2

    Conserved Domains (1) summary
    pfam04142
    Location:1 → 181
    Nuc_sug_transp; Nucleotide-sugar transporter
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9R0M8.1 GenPept UniProtKB/Swiss-Prot:Q9R0M8

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