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Ube2h ubiquitin-conjugating enzyme E2H [ Mus musculus (house mouse) ]

Gene ID: 22214, updated on 27-Nov-2024

Summary

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Official Symbol
Ube2hprovided by MGI
Official Full Name
ubiquitin-conjugating enzyme E2Hprovided by MGI
Primary source
MGI:MGI:104632
See related
Ensembl:ENSMUSG00000039159 AllianceGenome:MGI:104632
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Gid3; Ubc8; E2-20K; 1500009C23Rik
Summary
Enables ubiquitin conjugating enzyme activity. Acts upstream of or within proteasome-mediated ubiquitin-dependent protein catabolic process. Predicted to be active in nucleus. Is expressed in several structures, including alimentary system; brain; genitourinary system; hemolymphoid system gland; and liver and biliary system. Orthologous to human UBE2H (ubiquitin conjugating enzyme E2 H). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in ovary adult (RPKM 28.8), bladder adult (RPKM 28.5) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Ube2h in Genome Data Viewer
Location:
6 A3.3; 6 12.52 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (30211288..30304538, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (30211289..30304539, complement)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene expressed sequence BB283400 Neighboring gene predicted gene, 31221 Neighboring gene STARR-seq mESC enhancer starr_15462 Neighboring gene CapStarr-seq enhancer MGSCv37_chr6:30250507-30250717 Neighboring gene RIKEN cDNA 1700095J07 gene Neighboring gene STARR-positive B cell enhancer ABC_E4817 Neighboring gene CapStarr-seq enhancer MGSCv37_chr6:30290290-30290473 Neighboring gene STARR-seq mESC enhancer starr_15465 Neighboring gene STARR-positive B cell enhancer mm9_chr6:30307653-30307954 Neighboring gene zinc finger, C3HC type 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Characterization of a cDNA clone encoding E2-20K, a murine ubiquitin-conjugating enzyme. Wefes I, et al. Gene, 1995 Oct 3. PMID 7590289
  2. Induction of ubiquitin-conjugating enzymes during terminal erythroid differentiation. Wefes I, et al. Proc Natl Acad Sci U S A, 1995 May 23. PMID 7761435, Free PMC Article
  3. MG53-induced IRS-1 ubiquitination negatively regulates skeletal myogenesis and insulin signalling. Yi JS, et al. Nat Commun, 2013. PMID 23965929, Free PMC Article
  4. Human-mouse comparative mapping of the genomic region containing CDK6: localization of an evolutionary breakpoint. Thomas JW, et al. Mamm Genome, 1999 Jul. PMID 10384057
  5. Interferon-inducible ubiquitin E2, Ubc8, is a conjugating enzyme for protein ISGylation. Kim KI, et al. Mol Cell Biol, 2004 Nov. PMID 15485925, Free PMC Article

See all (25) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. MG53 is an ubiquitin E3 ligase that induces IRS-1 ubiquitination with the help of an E2-conjugating enzyme, UBE2H.
    Title: MG53-induced IRS-1 ubiquitination negatively regulates skeletal myogenesis and insulin signalling.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Targeted (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ubiquitin conjugating enzyme activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ubiquitin conjugating enzyme activity IGI
Inferred from Genetic Interaction
more info
 PubMed 
enables ubiquitin-protein transferase activity ISO
Inferred from Sequence Orthology
more info
  
enables ubiquitin-protein transferase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within proteasome-mediated ubiquitin-dependent protein catabolic process IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in protein K11-linked ubiquitination ISO
Inferred from Sequence Orthology
more info
  
involved_in protein K11-linked ubiquitination ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in protein K48-linked ubiquitination ISO
Inferred from Sequence Orthology
more info
  
involved_in protein K48-linked ubiquitination ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in protein polyubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
ubiquitin-conjugating enzyme E2 H
Names
(E3-independent) E2 ubiquitin-conjugating enzyme H
E2 ubiquitin-conjugating enzyme H
UBCH2
ubiquitin carrier protein H
ubiquitin-conjugating enzyme E2-20K
ubiquitin-protein ligase H
NP_001163047.1
NP_001163048.1
NP_033485.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001169576.1 → NP_001163047.1  ubiquitin-conjugating enzyme E2 H isoform 2

    See identical proteins and their annotated locations for NP_001163047.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame segment compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    AC161538, AK131688, AK161414, CF539343
    Consensus CDS
    CCDS51743.1
    UniProtKB/TrEMBL
    E9Q3U1, Q3TTE3
    Related
    ENSMUSP00000092121.3, ENSMUST00000094543.3
    Conserved Domains (1) summary
    cl00154
    Location:31 → 114
    UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...

  2. NM_001169577.1 → NP_001163048.1  ubiquitin-conjugating enzyme E2 H isoform 3

    See identical proteins and their annotated locations for NP_001163048.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (3) is shorter at the N-terminus compared to isoform 1.
    Source sequence(s)
    AC161538
    Conserved Domains (1) summary
    cl00154
    Location:1 → 75
    UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...

  3. NM_009459.3 → NP_033485.1  ubiquitin-conjugating enzyme E2 H isoform 1

    See identical proteins and their annotated locations for NP_033485.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AC161538, AK131688, CF539343
    Consensus CDS
    CCDS19969.1
    UniProtKB/Swiss-Prot
    P62257
    UniProtKB/TrEMBL
    Q3TTE3, Q3V2N4
    Related
    ENSMUSP00000100058.4, ENSMUST00000102993.10
    Conserved Domains (1) summary
    pfam00179
    Location:31 → 145
    UQ_con; Ubiquitin-conjugating enzyme

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    30211288..30304538 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P62257.1 GenPept UniProtKB/Swiss-Prot:P62257

Gene LinkOut

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