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ADGRF5 adhesion G protein-coupled receptor F5 [ Homo sapiens (human) ]

Gene ID: 221395, updated on 27-Nov-2024

Summary

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Official Symbol
ADGRF5provided by HGNC
Official Full Name
adhesion G protein-coupled receptor F5provided by HGNC
Primary source
HGNC:HGNC:19030
See related
Ensembl:ENSG00000069122 MIM:620874; AllianceGenome:HGNC:19030
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
GPR116; KPG_001
Summary
Predicted to enable G protein-coupled receptor activity. Predicted to be involved in several processes, including adenylate cyclase-activating G protein-coupled receptor signaling pathway; energy reserve metabolic process; and fat cell differentiation. Predicted to act upstream of or within several processes, including glomerular filtration; negative regulation of macrophage activation; and pharyngeal arch artery morphogenesis. Located in cell surface and cytoplasmic vesicle. [provided by Alliance of Genome Resources, Nov 2024]
Expression
Broad expression in lung (RPKM 71.0), fat (RPKM 49.8) and 16 other tissues See more
Orthologs
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Genomic context

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See ADGRF5 in Genome Data Viewer
Location:
6p12.3
Exon count:
25
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 6 NC_000006.12 (46852522..46954939, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 6 NC_060930.1 (46689996..46792404, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (46820259..46922676, complement)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene ankyrin repeat domain 66 Neighboring gene meprin A subunit alpha Neighboring gene NANOG hESC enhancer GRCh37_chr6:46814578-46815142 Neighboring gene uncharacterized LOC124901488 Neighboring gene ADGRF5 antisense RNA 1 Neighboring gene uncharacterized LOC105375080 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr6:46894113-46895312 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr6:46930563-46931189 Neighboring gene uncharacterized LOC124901489 Neighboring gene H3K27ac hESC enhancer GRCh37_chr6:46952137-46952638 Neighboring gene adhesion G protein-coupled receptor F1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. GPR116 alleviates acetaminophen-induced liver injury in mice by inhibiting endoplasmic reticulum stress. Xiang Q, et al. Cell Mol Life Sci, 2024 Jul 13. PMID 39001944, Free PMC Article
  2. The clinical relevance of the adhesion G protein-coupled receptor F5 for human diseases and cancers. Jacenik D, et al. Biochim Biophys Acta Mol Basis Dis, 2023 Jun. PMID 36878303, Free PMC Article
  3. The Expression Pattern of Adhesion G Protein-Coupled Receptor F5 Is Related to Cell Adhesion and Metastatic Pathways in Colorectal Cancer-Comprehensive Study Based on In Silico Analysis. Kang H, et al. Cells, 2022 Dec 1. PMID 36497132, Free PMC Article
  4. GPR116, an adhesion G-protein-coupled receptor, promotes breast cancer metastasis via the Gαq-p63RhoGEF-Rho GTPase pathway. Tang X, et al. Cancer Res, 2013 Oct 15. PMID 24008316
  5. High expression of GPR116 indicates poor survival outcome and promotes tumor progression in colorectal carcinoma. Yang L, et al. Oncotarget, 2017 Jul 18. PMID 28624786, Free PMC Article

See all (37) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The adhesion-GPCR ADGRF5 fuels breast cancer progression by suppressing the MMP8-mediated antitumorigenic effects.
    Title: The adhesion-GPCR ADGRF5 fuels breast cancer progression by suppressing the MMP8-mediated antitumorigenic effects.
  2. GPR116 alleviates acetaminophen-induced liver injury in mice by inhibiting endoplasmic reticulum stress.
    Title: GPR116 alleviates acetaminophen-induced liver injury in mice by inhibiting endoplasmic reticulum stress.
  3. The clinical relevance of the adhesion G protein-coupled receptor F5 for human diseases and cancers.
    Title: The clinical relevance of the adhesion G protein-coupled receptor F5 for human diseases and cancers.
  4. The Expression Pattern of Adhesion G Protein-Coupled Receptor F5 Is Related to Cell Adhesion and Metastatic Pathways in Colorectal Cancer-Comprehensive Study Based on In Silico Analysis.
    Title: The Expression Pattern of Adhesion G Protein-Coupled Receptor F5 Is Related to Cell Adhesion and Metastatic Pathways in Colorectal Cancer-Comprehensive Study Based on In Silico Analysis.
  5. Recurrent novel THBS1-ADGRF5 gene fusion in a new tumor subtype ""Acral FibroChondroMyxoid Tumors"".
    Title: Recurrent novel THBS1-ADGRF5 gene fusion in a new tumor subtype "Acral FibroChondroMyxoid Tumors".
  6. Orphan GPR116 mediates the insulin sensitizing effects of the hepatokine FNDC4 in adipose tissue.
    Title: Orphan GPR116 mediates the insulin sensitizing effects of the hepatokine FNDC4 in adipose tissue.
  7. Adhesion-GPCR Gpr116 (ADGRF5) expression inhibits renal acid secretion.
    Title: Adhesion-GPCR Gpr116 (ADGRF5) expression inhibits renal acid secretion.
  8. MiR-511-5p functions as a tumor suppressor and a predictive of prognosis in colorectal cancer by directly targeting GPR116.
    Title: MiR-511-5p functions as a tumor suppressor and a predictive of prognosis in colorectal cancer by directly targeting GPR116.
  9. our study demonstrated that GPR116 was significantly upregulated in CRC tissues and could serve as an independent prognostic indicator for patients with CRC.
    Title: High expression of GPR116 indicates poor survival outcome and promotes tumor progression in colorectal carcinoma.
  10. These findings show that GPR116 is crucial for the metastasis of breast cancer and support GPR116 as a potential prognostic marker and drug target against metastatic human breast cancer.
    Title: GPR116, an adhesion G-protein-coupled receptor, promotes breast cancer metastasis via the Gαq-p63RhoGEF-Rho GTPase pathway.
Submit: New GeneRIF Correction See all GeneRIFs (16)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ90640, KIAA0758, DKFZp564O1923

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables G protein-coupled receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway TAS
Traceable Author Statement
more info
 PubMed 
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cell surface receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in energy reserve metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in erythrocyte development IEA
Inferred from Electronic Annotation
more info
  
involved_in fat cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in glomerular filtration IEA
Inferred from Electronic Annotation
more info
  
involved_in glucose homeostasis IEA
Inferred from Electronic Annotation
more info
  
involved_in macrophage activation IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of macrophage activation IEA
Inferred from Electronic Annotation
more info
  
involved_in pharyngeal arch artery morphogenesis IEA
Inferred from Electronic Annotation
more info
  
involved_in phospholipid biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of phospholipid biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of lipid metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in surfactant homeostasis IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in apical part of cell IEA
Inferred from Electronic Annotation
more info
  
located_in cell surface IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cytoplasmic vesicle IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasmic vesicle IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane TAS
Traceable Author Statement
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
adhesion G protein-coupled receptor F5
Names
G-protein coupled receptor 116
Ig-Hepta homolog
probable G-protein coupled receptor 116

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001098518.2 → NP_001091988.1  adhesion G protein-coupled receptor F5 precursor

    See identical proteins and their annotated locations for NP_001091988.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same isoform.
    Source sequence(s)
    AB018301, AL096772, AY140958, AY498875, DB230925
    Consensus CDS
    CCDS4919.1
    UniProtKB/Swiss-Prot
    O94858, Q5TF06, Q6RGN2, Q86SP0, Q8IZF2, Q9Y3Z2
    UniProtKB/TrEMBL
    A8K0D8
    Related
    ENSP00000283296.7, ENST00000283296.12
    Conserved Domains (6) summary
    smart00408
    Location:285 → 351
    IGc2; Immunoglobulin C-2 Type
    smart00410
    Location:477 → 562
    IG_like; Immunoglobulin like
    pfam00001
    Location:1030 → 1268
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    pfam01390
    Location:170 → 259
    SEA; SEA domain
    pfam01825
    Location:954 → 996
    GPS; GPCR proteolysis site, GPS, motif
    cl21561
    Location:1011 → 1262
    7tm_4; Olfactory receptor

  2. NM_015234.5 → NP_056049.4  adhesion G protein-coupled receptor F5 precursor

    See identical proteins and their annotated locations for NP_056049.4

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. Variants 1 and 2 encode the same isoform.
    Source sequence(s)
    AL096772, AY140958, AY498875, DA588699
    Consensus CDS
    CCDS4919.1
    UniProtKB/Swiss-Prot
    O94858, Q5TF06, Q6RGN2, Q86SP0, Q8IZF2, Q9Y3Z2
    UniProtKB/TrEMBL
    A8K0D8
    Related
    ENSP00000265417.6, ENST00000265417.7
    Conserved Domains (6) summary
    smart00408
    Location:285 → 351
    IGc2; Immunoglobulin C-2 Type
    smart00410
    Location:477 → 562
    IG_like; Immunoglobulin like
    pfam00001
    Location:1030 → 1268
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    pfam01390
    Location:170 → 259
    SEA; SEA domain
    pfam01825
    Location:954 → 996
    GPS; GPCR proteolysis site, GPS, motif
    cl21561
    Location:1011 → 1262
    7tm_4; Olfactory receptor

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p14 Primary Assembly

    Range
    46852522..46954939 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047418326.1 → XP_047274282.1  adhesion G protein-coupled receptor F5 isoform X5

  2. XM_005248893.4 → XP_005248950.1  adhesion G protein-coupled receptor F5 isoform X1

    See identical proteins and their annotated locations for XP_005248950.1

    UniProtKB/TrEMBL
    A8K0D8
    Conserved Domains (6) summary
    smart00408
    Location:285 → 351
    IGc2; Immunoglobulin C-2 Type
    smart00410
    Location:517 → 602
    IG_like; Immunoglobulin like
    pfam00001
    Location:1070 → 1308
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    pfam01390
    Location:170 → 259
    SEA; SEA domain
    pfam01825
    Location:994 → 1036
    GPS; GPCR proteolysis site, GPS, motif
    cl21561
    Location:1051 → 1302
    7tm_4; Olfactory receptor

  3. XM_017010422.3 → XP_016865911.1  adhesion G protein-coupled receptor F5 isoform X4

    UniProtKB/TrEMBL
    A8K0D8

  4. XM_005248892.4 → XP_005248949.1  adhesion G protein-coupled receptor F5 isoform X1

    See identical proteins and their annotated locations for XP_005248949.1

    UniProtKB/TrEMBL
    A8K0D8
    Conserved Domains (6) summary
    smart00408
    Location:285 → 351
    IGc2; Immunoglobulin C-2 Type
    smart00410
    Location:517 → 602
    IG_like; Immunoglobulin like
    pfam00001
    Location:1070 → 1308
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    pfam01390
    Location:170 → 259
    SEA; SEA domain
    pfam01825
    Location:994 → 1036
    GPS; GPCR proteolysis site, GPS, motif
    cl21561
    Location:1051 → 1302
    7tm_4; Olfactory receptor

  5. XM_005248895.5 → XP_005248952.1  adhesion G protein-coupled receptor F5 isoform X3

    UniProtKB/TrEMBL
    A8K0D8
    Conserved Domains (6) summary
    smart00408
    Location:285 → 351
    IGc2; Immunoglobulin C-2 Type
    smart00410
    Location:517 → 602
    IG_like; Immunoglobulin like
    pfam00001
    Location:1070 → 1308
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    pfam01390
    Location:170 → 259
    SEA; SEA domain
    pfam01825
    Location:994 → 1036
    GPS; GPCR proteolysis site, GPS, motif
    cl21561
    Location:1051 → 1302
    7tm_4; Olfactory receptor

  6. XM_005248894.5 → XP_005248951.1  adhesion G protein-coupled receptor F5 isoform X2

    UniProtKB/TrEMBL
    A8K0D8
    Conserved Domains (6) summary
    smart00408
    Location:285 → 351
    IGc2; Immunoglobulin C-2 Type
    smart00410
    Location:517 → 602
    IG_like; Immunoglobulin like
    pfam00001
    Location:1070 → 1308
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    pfam01390
    Location:170 → 259
    SEA; SEA domain
    pfam01825
    Location:994 → 1036
    GPS; GPCR proteolysis site, GPS, motif
    cl21561
    Location:1051 → 1302
    7tm_4; Olfactory receptor

  7. XM_047418327.1 → XP_047274283.1  adhesion G protein-coupled receptor F5 isoform X6

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060930.1 Alternate T2T-CHM13v2.0

    Range
    46689996..46792404 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054354567.1 → XP_054210542.1  adhesion G protein-coupled receptor F5 isoform X5

  2. XM_054354563.1 → XP_054210538.1  adhesion G protein-coupled receptor F5 isoform X1

  3. XM_054354566.1 → XP_054210541.1  adhesion G protein-coupled receptor F5 isoform X4

  4. XM_054354562.1 → XP_054210537.1  adhesion G protein-coupled receptor F5 isoform X1

  5. XM_054354565.1 → XP_054210540.1  adhesion G protein-coupled receptor F5 isoform X3

  6. XM_054354564.1 → XP_054210539.1  adhesion G protein-coupled receptor F5 isoform X2

  7. XM_054354568.1 → XP_054210543.1  adhesion G protein-coupled receptor F5 isoform X6

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8IZF2.3 GenPept UniProtKB/Swiss-Prot:Q8IZF2

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