Tsc2 TSC complex subunit 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Tsc2provided by MGI
Official Full Name: TSC complex subunit 2provided by MGI
Primary source: MGI:MGI:102548
See related: Ensembl:ENSMUSG00000002496 AllianceGenome:MGI:102548
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Tcs2; Nafld
Summary: Enables 14-3-3 protein binding activity and GTPase activator activity. Involved in several processes, including anoikis; chemical synaptic transmission; and negative regulation of TORC1 signaling. Acts upstream of or within several processes, including intracellular protein transport; negative regulation of lymphocyte proliferation; and regulation of signal transduction. Located in cytoplasm. Part of TSC1-TSC2 complex. Is active in lysosomal membrane and synapse. Is expressed in several structures, including aorta; central nervous system; genitourinary system; hemolymphoid system gland; and retina. Used to study autism spectrum disorder; tuberous sclerosis; and uterine fibroid. Human ortholog(s) of this gene implicated in hepatic angiomyolipoma; lymphangioleiomyomatosis; medulloblastoma; tuberous sclerosis; and tuberous sclerosis 2. Orthologous to human TSC2 (TSC complex subunit 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in lung adult (RPKM 31.9), ovary adult (RPKM 27.3) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 17 A3.3; 17 12.41 cM

Exon count:: 42

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	17	NC_000083.7 (24814788..24851607, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	17	NC_000083.6 (24595816..24632676, complement)

Chromosome 17 - NC_000083.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Defining the In Vivo Role of mTORC1 in Thyrocytes by Studying the TSC2 Conditional Knockout Mouse Model.
Title: Defining the In Vivo Role of mTORC1 in Thyrocytes by Studying the TSC2 Conditional Knockout Mouse Model.
Regulation of TSC2 lysosome translocation and mitochondrial turnover by TSC2 acetylation status.
Title: Regulation of TSC2 lysosome translocation and mitochondrial turnover by TSC2 acetylation status.
Hyperactive mTORC1 in lung mesenchyme induces endothelial cell dysfunction and pulmonary vascular remodeling.
Title: Hyperactive mTORC1 in lung mesenchyme induces endothelial cell dysfunction and pulmonary vascular remodeling.
Nutrient deprivation induces mouse embryonic diapause mediated by Gator1 and Tsc2.
Title: Nutrient deprivation induces mouse embryonic diapause mediated by Gator1 and Tsc2.
Bcat1 is controlled by Tsc2/mTORC1 pathway at expression levels and its deficiency together with Bcat2 inactivation suppresses the growth of a Tsc2[-/-] tumor cell line.
Title: Bcat1 is controlled by Tsc2/mTORC1 pathway at expression levels and its deficiency together with Bcat2 inactivation suppresses the growth of a Tsc2(-/-) tumor cell line.
Cross-talk between TSC2 and the extracellular matrix controls pulmonary vascular proliferation and pulmonary hypertension.
Title: Cross-talk between TSC2 and the extracellular matrix controls pulmonary vascular proliferation and pulmonary hypertension.
Knockout of TSC2 in Nav1.8+ neurons predisposes to the onset of normal weight obesity.
Title: Knockout of TSC2 in Nav1.8+ neurons predisposes to the onset of normal weight obesity.
Tsc2 mutation rather than Tsc1 mutation dominantly causes a social deficit in a mouse model of tuberous sclerosis complex.
Title: Tsc2 mutation rather than Tsc1 mutation dominantly causes a social deficit in a mouse model of tuberous sclerosis complex.
Loss of myeloid Tsc2 predisposes to angiotensin II-induced aortic aneurysm formation in mice.
Title: Loss of myeloid Tsc2 predisposes to angiotensin II-induced aortic aneurysm formation in mice.
The non-essential TSC complex component TBC1D7 restricts tissue mTORC1 signaling and brain and neuron growth.
Title: The non-essential TSC complex component TBC1D7 restricts tissue mTORC1 signaling and brain and neuron growth.

Submit: New GeneRIF Correction See all GeneRIFs (136)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (6) 1 citation
Targeted (15) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Pkd1 (e-PCR), detects polymorphism
- UniSTS:531218

Tsc2 (e-PCR), detects polymorphism
- UniSTS:265679

Tsc2 (e-PCR), detects polymorphism
- UniSTS:265680

Tsc2 (e-PCR), detects polymorphism
- UniSTS:265681

Tsc2 (e-PCR), detects polymorphism
- UniSTS:265682

Tsc2 (e-PCR), detects polymorphism
- UniSTS:265683

Tsc2 (e-PCR), detects polymorphism
- UniSTS:265684

Tsc2 (e-PCR), detects polymorphism
- UniSTS:265685

Tsc2 (e-PCR), detects polymorphism
- UniSTS:527589

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables 14-3-3 protein binding	IDA Inferred from Direct Assay more info	PubMed
enables GTPase activator activity	IBA Inferred from Biological aspect of Ancestor more info
enables GTPase activator activity	IDA Inferred from Direct Assay more info	PubMed
enables GTPase activator activity	IEA Inferred from Electronic Annotation more info
enables GTPase activator activity	ISO Inferred from Sequence Orthology more info
enables Hsp90 protein binding	IEA Inferred from Electronic Annotation more info
enables Hsp90 protein binding	ISO Inferred from Sequence Orthology more info
enables phosphatase binding	IEA Inferred from Electronic Annotation more info
enables phosphatase binding	ISO Inferred from Sequence Orthology more info
enables phosphatase binding	ISS Inferred from Sequence or Structural Similarity more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein homodimerization activity	IEA Inferred from Electronic Annotation more info
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info
enables protein-containing complex binding	ISO Inferred from Sequence Orthology more info
enables small GTPase binding	IEA Inferred from Electronic Annotation more info
enables small GTPase binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of B cell proliferation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within D-glucose import	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of T cell proliferation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in anoikis	IEA Inferred from Electronic Annotation more info
involved_in anoikis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in anoikis	ISO Inferred from Sequence Orthology more info
acts_upstream_of cell population proliferation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of cell population proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cell projection organization	ISO Inferred from Sequence Orthology more info	PubMed
acts_upstream_of_or_within cellular response to insulin stimulus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular response to starvation	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to starvation	IEA Inferred from Electronic Annotation more info
involved_in cellular response to starvation	ISO Inferred from Sequence Orthology more info
involved_in establishment of cell polarity	ISO Inferred from Sequence Orthology more info
involved_in excitatory chemical synaptic transmission	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within heart development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in inhibitory chemical synaptic transmission	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of B cell proliferation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within negative regulation of T cell proliferation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of TOR signaling	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of TOR signaling	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within negative regulation of TOR signaling	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of TOR signaling	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of TORC1 signaling	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of TORC1 signaling	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of TORC1 signaling	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of TORC1 signaling	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of Wnt signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of Wnt signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of axonogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of cell population proliferation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within negative regulation of cell population proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of cell size	ISO Inferred from Sequence Orthology more info	PubMed
involved_in negative regulation of epithelial cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of epithelial to mesenchymal transition	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of fibroblast proliferation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of insulin receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of macroautophagy	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of pinocytosis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of protein kinase activity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of protein phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of vascular endothelial cell proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within neural tube closure	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive chemotaxis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of autophagy	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cell adhesion	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of dendritic spine development	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of fibroblast migration	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of insulin receptor signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within positive regulation of insulin receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of macroautophagy	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of macroautophagy	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of macroautophagy	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of macroautophagy	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of neuron projection development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within protein import into nucleus	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within protein localization	IDA Inferred from Direct Assay more info	PubMed
involved_in protein localization to cell surface	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within protein transport into plasma membrane raft	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of cell cycle	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within regulation of endocytosis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of insulin receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of postsynapse organization	ISO Inferred from Sequence Orthology more info
involved_in regulation of small GTPase mediated signal transduction	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within response to hypoxia	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in social behavior	ISO Inferred from Sequence Orthology more info
acts_upstream_of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in Golgi apparatus	IEA Inferred from Electronic Annotation more info
located_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
part_of TSC1-TSC2 complex	IBA Inferred from Biological aspect of Ancestor more info
part_of TSC1-TSC2 complex	IDA Inferred from Direct Assay more info	PubMed
part_of TSC1-TSC2 complex	IEA Inferred from Electronic Annotation more info
part_of TSC1-TSC2 complex	ISO Inferred from Sequence Orthology more info
located_in caveola	ISO Inferred from Sequence Orthology more info
located_in cell projection	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
colocalizes_with cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in dendrite	ISO Inferred from Sequence Orthology more info
is_active_in glutamatergic synapse	ISO Inferred from Sequence Orthology more info
located_in growth cone	ISO Inferred from Sequence Orthology more info
is_active_in lysosomal membrane	IDA Inferred from Direct Assay more info	PubMed
located_in lysosomal membrane	IEA Inferred from Electronic Annotation more info
is_active_in lysosomal membrane	ISO Inferred from Sequence Orthology more info
located_in lysosome	ISO Inferred from Sequence Orthology more info
located_in membrane	ISO Inferred from Sequence Orthology more info
located_in neuronal cell body	ISO Inferred from Sequence Orthology more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in perinuclear region of cytoplasm	IEA Inferred from Electronic Annotation more info
located_in perinuclear region of cytoplasm	ISO Inferred from Sequence Orthology more info
located_in postsynaptic density	IEA Inferred from Electronic Annotation more info
is_active_in postsynaptic density	ISO Inferred from Sequence Orthology more info
is_active_in synapse	EXP Inferred from Experiment more info	PubMed
is_active_in synapse	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: tuberin

Names: tuberous sclerosis 2 protein homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001039363.3 → NP_001034452.1 tuberin isoform 2

See identical proteins and their annotated locations for NP_001034452.1

Status: VALIDATED

Source sequence(s)

AC132367

Consensus CDS

CCDS28486.1

UniProtKB/TrEMBL

Q3TCQ7, Q7TT21

Related

ENSMUSP00000094986.2, ENSMUST00000097373.2

Conserved Domains (3) summary

pfam02145
Location:1498 → 1684

Rap_GAP; Rap/ran-GAP

pfam03542
Location:555 → 903

Tuberin

pfam11864
Location:54 → 419

DUF3384; Domain of unknown function (DUF3384)
NM_001286713.2 → NP_001273642.1 tuberin isoform 3

See identical proteins and their annotated locations for NP_001273642.1

Status: VALIDATED

Source sequence(s)

AC132367

Consensus CDS

CCDS89010.1

UniProtKB/TrEMBL

Q3UG88, Q3UHB2

Related

ENSMUSP00000154338.2, ENSMUST00000227745.2

Conserved Domains (3) summary

pfam02145
Location:1564 → 1750

Rap_GAP; Rap/ran-GAP

pfam03542
Location:555 → 903

Tuberin

pfam11864
Location:54 → 469

DUF3384; Domain of unknown function (DUF3384)
NM_001286714.2 → NP_001273643.1 tuberin isoform 1

See identical proteins and their annotated locations for NP_001273643.1

Status: VALIDATED

Source sequence(s)

AC132367

Consensus CDS

CCDS89009.1

UniProtKB/TrEMBL

A0A2I3BPP1, Q3UG88

Conserved Domains (3) summary

pfam02145
Location:1541 → 1727

Rap_GAP; Rap/ran-GAP

pfam03542
Location:555 → 903

Tuberin; Tuberin

pfam11864
Location:54 → 466

DUF3384; Domain of unknown function (DUF3384)
NM_001286716.2 → NP_001273645.1 tuberin isoform 2

See identical proteins and their annotated locations for NP_001273645.1

Status: VALIDATED

Source sequence(s)

AC132367

Consensus CDS

CCDS28486.1

UniProtKB/TrEMBL

Q3TCQ7, Q7TT21

Related

ENSMUSP00000153792.2, ENSMUST00000226398.2

Conserved Domains (3) summary

pfam02145
Location:1498 → 1684

Rap_GAP; Rap/ran-GAP

pfam03542
Location:555 → 903

Tuberin

pfam11864
Location:54 → 419

DUF3384; Domain of unknown function (DUF3384)
NM_001286718.2 → NP_001273647.1 tuberin isoform 4

Status: VALIDATED

Source sequence(s)

AC132367

Consensus CDS

CCDS89008.1

UniProtKB/TrEMBL

A0A2I3BRT5, Q3TCQ7

Related

ENSMUSP00000154706.2, ENSMUST00000228412.2

Conserved Domains (3) summary

pfam02145
Location:1497 → 1683

Rap_GAP; Rap/ran-GAP

pfam03542
Location:555 → 903

Tuberin; Tuberin

pfam11864
Location:54 → 466

DUF3384; Domain of unknown function (DUF3384)
NM_001286720.2 → NP_001273649.1 tuberin isoform 5

See identical proteins and their annotated locations for NP_001273649.1

Status: VALIDATED

Source sequence(s)

AC132367

UniProtKB/Swiss-Prot

P97723, P97724, P97725, P97727, Q61007, Q61008, Q61037, Q9WUF6

Conserved Domains (3) summary

pfam02145
Location:1564 → 1756

Rap_GAP; Rap/ran-GAP

pfam03542
Location:555 → 903

Tuberin; Tuberin

pfam11864
Location:54 → 466

DUF3384; Domain of unknown function (DUF3384)
NM_001403402.1 → NP_001390331.1 tuberin isoform 16

Status: VALIDATED

Source sequence(s)

AC132367
NM_001403403.1 → NP_001390332.1 tuberin isoform 17

Status: VALIDATED

Source sequence(s)

AC132367
NM_001403404.1 → NP_001390333.1 tuberin isoform 17

Status: VALIDATED

Source sequence(s)

AC132367
NM_001403405.1 → NP_001390334.1 tuberin isoform 16

Status: VALIDATED

Source sequence(s)

AC132367
NM_001403406.1 → NP_001390335.1 tuberin isoform 15

Status: VALIDATED

Source sequence(s)

AC132367
NM_001403407.1 → NP_001390336.1 tuberin isoform 14

Status: VALIDATED

Source sequence(s)

AC132367
NM_001403408.1 → NP_001390337.1 tuberin isoform 13

Status: VALIDATED

Source sequence(s)

AC132367
NM_001403409.1 → NP_001390338.1 tuberin isoform 12

Status: VALIDATED

Source sequence(s)

AC132367
NM_001403410.1 → NP_001390339.1 tuberin isoform 11

Status: VALIDATED

Source sequence(s)

AC132367
NM_001403411.1 → NP_001390340.1 tuberin isoform 11

Status: VALIDATED

Source sequence(s)

AC132367
NM_001403412.1 → NP_001390341.1 tuberin isoform 10

Status: VALIDATED

Source sequence(s)

AC132367
NM_001403413.1 → NP_001390342.1 tuberin isoform 9

Status: VALIDATED

Source sequence(s)

AC132367
NM_001403414.1 → NP_001390343.1 tuberin isoform 6

Status: VALIDATED

Source sequence(s)

AC132367
NM_001403415.1 → NP_001390344.1 tuberin isoform 8

Status: VALIDATED

Source sequence(s)

AC132367
NM_001403416.1 → NP_001390345.1 tuberin isoform 7

Status: VALIDATED

Source sequence(s)

AC132367
NM_001403417.1 → NP_001390346.1 tuberin isoform 4

Status: VALIDATED

Source sequence(s)

AC132367
NM_001403418.1 → NP_001390347.1 tuberin isoform 6

Status: VALIDATED

Source sequence(s)

AC132367
NM_011647.4 → NP_035777.2 tuberin isoform 1

See identical proteins and their annotated locations for NP_035777.2

Status: VALIDATED

Source sequence(s)

AC132367

Consensus CDS

CCDS89009.1

UniProtKB/TrEMBL

A0A2I3BPP1, Q3UG88

Related

ENSMUSP00000153869.2, ENSMUST00000226284.2

Conserved Domains (3) summary

pfam02145
Location:1541 → 1727

Rap_GAP; Rap/ran-GAP

pfam03542
Location:555 → 903

Tuberin; Tuberin

pfam11864
Location:54 → 466

DUF3384; Domain of unknown function (DUF3384)

RNA

NR_175374.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

AC132367

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000083.7 Reference GRCm39 C57BL/6J

Range

24814788..24851607 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017317386.2 → XP_017172875.1 tuberin isoform X2

UniProtKB/TrEMBL

Q3UG88

Conserved Domains (3) summary

pfam02145
Location:1563 → 1749

Rap_GAP; Rap/ran-GAP

pfam03542
Location:554 → 902

Tuberin

pfam11864
Location:54 → 468

DUF3384; Domain of unknown function (DUF3384)
XM_017317384.3 → XP_017172873.1 tuberin isoform X19

UniProtKB/TrEMBL

Q3UG88, Q3UHB2

Conserved Domains (3) summary

pfam02145
Location:1564 → 1750

Rap_GAP; Rap/ran-GAP

pfam03542
Location:555 → 903

Tuberin

pfam11864
Location:54 → 469

DUF3384; Domain of unknown function (DUF3384)
XM_017317393.2 → XP_017172882.1 tuberin isoform X16

UniProtKB/TrEMBL

Q3TCQ7

Related

ENSMUSP00000153758.2, ENSMUST00000227607.2

Conserved Domains (3) summary

pfam02145
Location:1439 → 1625

Rap_GAP; Rap/ran-GAP

pfam03542
Location:496 → 844

Tuberin

pfam11864
Location:1 → 410

DUF3384; Domain of unknown function (DUF3384)
XM_030249647.2 → XP_030105507.1 tuberin isoform X10

UniProtKB/TrEMBL

Q3UG88

Conserved Domains (3) summary

pfam02145
Location:1505 → 1691

Rap_GAP; Rap/ran-GAP

pfam03542
Location:496 → 844

Tuberin

pfam11864
Location:1 → 410

DUF3384; Domain of unknown function (DUF3384)
XM_036160475.1 → XP_036016368.1 tuberin isoform X3

UniProtKB/TrEMBL

Q3UG88

Conserved Domains (3) summary

pfam02145
Location:1540 → 1726

Rap_GAP; Rap/ran-GAP

pfam03542
Location:555 → 903

Tuberin

pfam11864
Location:54 → 419

DUF3384; Domain of unknown function (DUF3384)
XM_030249646.2 → XP_030105506.1 tuberin isoform X2

UniProtKB/TrEMBL

Q3UG88

Conserved Domains (3) summary

pfam02145
Location:1563 → 1749

Rap_GAP; Rap/ran-GAP

pfam03542
Location:554 → 902

Tuberin

pfam11864
Location:54 → 468

DUF3384; Domain of unknown function (DUF3384)
XM_017317390.2 → XP_017172879.1 tuberin isoform X10

UniProtKB/TrEMBL

Q3UG88

Conserved Domains (3) summary

pfam02145
Location:1505 → 1691

Rap_GAP; Rap/ran-GAP

pfam03542
Location:496 → 844

Tuberin

pfam11864
Location:1 → 410

DUF3384; Domain of unknown function (DUF3384)
XM_030249650.2 → XP_030105510.1 tuberin isoform X11

UniProtKB/TrEMBL

Q3UG88

Conserved Domains (3) summary

pfam02145
Location:1504 → 1690

Rap_GAP; Rap/ran-GAP

pfam03542
Location:495 → 843

Tuberin

pfam11864
Location:1 → 409

DUF3384; Domain of unknown function (DUF3384)
XM_030249648.1 → XP_030105508.1 tuberin isoform X10

UniProtKB/TrEMBL

Q3UG88

Conserved Domains (3) summary

pfam02145
Location:1505 → 1691

Rap_GAP; Rap/ran-GAP

pfam03542
Location:496 → 844

Tuberin

pfam11864
Location:1 → 410

DUF3384; Domain of unknown function (DUF3384)