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Nr2c2 nuclear receptor subfamily 2, group C, member 2 [ Mus musculus (house mouse) ]

Gene ID: 22026, updated on 27-Nov-2024

Summary

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Official Symbol
Nr2c2provided by MGI
Official Full Name
nuclear receptor subfamily 2, group C, member 2provided by MGI
Primary source
MGI:MGI:1352466
See related
Ensembl:ENSMUSG00000005893 AllianceGenome:MGI:1352466
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Tr4; TAK1; mKIAA4145
Summary
Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and nuclear receptor activity. Involved in several processes, including p38MAPK cascade; positive regulation of embryonic development; and positive regulation of myoblast differentiation. Acts upstream of or within lipopolysaccharide-mediated signaling pathway; meiotic cell cycle; and spermatogenesis. Predicted to be located in nucleoplasm. Is expressed in several structures, including alimentary system; genitourinary system; integumental system; nervous system; and sensory organ. Orthologous to human NR2C2 (nuclear receptor subfamily 2 group C member 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in whole brain E14.5 (RPKM 13.2), thymus adult (RPKM 12.6) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Nr2c2 in Genome Data Viewer
Location:
6 D1; 6 41.03 cM
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (92068426..92150039)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (92091418..92173058)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 53299 Neighboring gene FYVE, RhoGEF and PH domain containing 5 Neighboring gene STARR-positive B cell enhancer ABC_E539 Neighboring gene predicted gene, 46967 Neighboring gene mitochondrial ribosomal protein S25 Neighboring gene rabenosyn, RAB effector Neighboring gene STARR-seq mESC enhancer starr_16664 Neighboring gene thyrotropin releasing hormone

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Cloning of the gene encoding the murine orphan receptor TAK1 and cell-type-specific expression in testis. Hirose T, et al. Gene, 1995 Oct 3. PMID 7590273
  2. TAK1 regulates Paneth cell integrity partly through blocking necroptosis. Simmons AN, et al. Cell Death Dis, 2016 Apr 14. PMID 27077812, Free PMC Article
  3. The role of TGF-β-activated kinase 1 in db/db mice and high glucose-induced macrophage. Xu X, et al. Int Immunopharmacol, 2016 Sep. PMID 27268284
  4. False responses of Renilla luciferase reporter control to nuclear receptor TR4. Zhang D, et al. Mol Cell Biochem, 2017 Jun. PMID 28210900
  5. Deficiency in TR4 nuclear receptor abrogates Gadd45a expression and increases cytotoxicity induced by ionizing radiation. Yan SJ, et al. Cell Mol Biol Lett, 2012 Jun. PMID 22396141, Free PMC Article

See all (117) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Roquin-2 promotes oxidative stress-induced cell death by ubiquitination-dependent degradation of TAK1.
    Title: Roquin-2 promotes oxidative stress-induced cell death by ubiquitination-dependent degradation of TAK1.
  2. Mycobacterium tuberculosis Rv1043c regulates the inflammatory response by inhibiting the phosphorylation of TAK1.
    Title: Mycobacterium tuberculosis Rv1043c regulates the inflammatory response by inhibiting the phosphorylation of TAK1.
  3. Disruption of TIGAR-TAK1 alleviates immunopathology in a murine model of sepsis.
    Title: Disruption of TIGAR-TAK1 alleviates immunopathology in a murine model of sepsis.
  4. TR4 worsen urosepsis by regulating GSDMD.
    Title: TR4 worsen urosepsis by regulating GSDMD.
  5. TAK1 is an essential kinase for STING trafficking.
    Title: TAK1 is an essential kinase for STING trafficking.
  6. Small molecule activators of TAK1 promotes its activity-dependent ubiquitination and TRAIL-mediated tumor cell death.
    Title: Small molecule activators of TAK1 promotes its activity-dependent ubiquitination and TRAIL-mediated tumor cell death.
  7. Transforming Growth Factor-beta-Activated Kinase 1 (TAK1) Mediates Chronic Pain and Cytokine Production in Mouse Models of Inflammatory, Neuropathic, and Primary Pain.
    Title: Transforming Growth Factor-β-Activated Kinase 1 (TAK1) Mediates Chronic Pain and Cytokine Production in Mouse Models of Inflammatory, Neuropathic, and Primary Pain.
  8. p-TAK1 acts as a switch between myoblast proliferation phase and differentiation phase in mdx mice via regulating HO-1 expression.
    Title: p-TAK1 acts as a switch between myoblast proliferation phase and differentiation phase in mdx mice via regulating HO-1 expression.
  9. Viperin impairs the innate immune response through the IRAK1-TRAF6-TAK1 axis to promote Mtb infection.
    Title: Viperin impairs the innate immune response through the IRAK1-TRAF6-TAK1 axis to promote Mtb infection.
  10. Gonadal hormone trigger the dynamic microglial alterations through Traf6/TAK1 axis that correlate with depressive behaviors.
    Title: Gonadal hormone trigger the dynamic microglial alterations through Traf6/TAK1 axis that correlate with depressive behaviors.
Submit: New GeneRIF Correction See all GeneRIFs (69)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 
  • Targeted (9)  1 citation

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • KIAA4145, MGC124356, MGC124357, MGC124358

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA-binding transcription activator activity, RNA polymerase II-specific ISO
Inferred from Sequence Orthology
more info
  
enables DNA-binding transcription factor activity IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription factor activity ISO
Inferred from Sequence Orthology
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables nuclear receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables sequence-specific double-stranded DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cell differentiation IEA
Inferred from Electronic Annotation
more info
  
involved_in cerebellum development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within lipopolysaccharide-mediated signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within meiotic cell cycle IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in p38MAPK cascade IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in positive regulation of behavior IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of embryonic development IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of embryonic development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of myoblast differentiation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within spermatogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
nuclear receptor subfamily 2 group C member 2
Names
nuclear receptor subfamily 2, group H, member 2
orphan nuclear receptor TAK1
orphan nuclear receptor TR4
orphan receptor, TR4
testicular receptor 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001347342.2 → NP_001334271.1  nuclear receptor subfamily 2 group C member 2 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1). Variants 1 and 3 both encode the same isoform (1).
    Source sequence(s)
    AC121593, AC164642
    Consensus CDS
    CCDS85096.1
    UniProtKB/TrEMBL
    G3X9W4, Q3U015
    Related
    ENSMUSP00000109090.2, ENSMUST00000113463.8
    Conserved Domains (2) summary
    cd06952
    Location:394 → 615
    NR_LBD_TR2_like; The ligand binding domain of the orphan nuclear receptors TR4 and TR2
    cd06967
    Location:145 → 231
    NR_DBD_TR2_like; DNA-binding domain of the TR2 and TR4 (human testicular receptor 2 and 4) is composed of two C4-type zinc fingers

  2. NM_001410478.1 → NP_001397407.1  nuclear receptor subfamily 2 group C member 2 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC121593, AC164642
    UniProtKB/TrEMBL
    G3X9W4

  3. NM_001410479.1 → NP_001397408.1  nuclear receptor subfamily 2 group C member 2 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC121593, AC164642
    UniProtKB/Swiss-Prot
    P49117, P55093
    UniProtKB/TrEMBL
    Q3ZAS1

  4. NM_001410480.1 → NP_001397409.1  nuclear receptor subfamily 2 group C member 2 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC121593, AC164642
    UniProtKB/Swiss-Prot
    P49117, P55093
    UniProtKB/TrEMBL
    Q3ZAS1
    Related
    ENSMUSP00000138465.2, ENSMUST00000146175.2

  5. NM_001410481.1 → NP_001397410.1  nuclear receptor subfamily 2 group C member 2 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC121593, AC164642
    UniProtKB/Swiss-Prot
    P49117, P55093
    UniProtKB/TrEMBL
    Q3ZAS1

  6. NM_001410482.1 → NP_001397411.1  nuclear receptor subfamily 2 group C member 2 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC121593, AC164642
    UniProtKB/Swiss-Prot
    P49117, P55093
    UniProtKB/TrEMBL
    Q3ZAS1

  7. NM_001410483.1 → NP_001397412.1  nuclear receptor subfamily 2 group C member 2 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC121593, AC164642

  8. NM_001410484.1 → NP_001397413.1  nuclear receptor subfamily 2 group C member 2 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC121593, AC164642

  9. NM_001410485.1 → NP_001397414.1  nuclear receptor subfamily 2 group C member 2 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC121593, AC164642

  10. NM_011630.4 → NP_035760.1  nuclear receptor subfamily 2 group C member 2 isoform 2

    See identical proteins and their annotated locations for NP_035760.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and coding region, compared to variant 1. These differences cause translation initiation at a downstream AUG and results in an isoform (2) with a shorter N-terminus, compared to isoform 1. Variants 2 and 4-7 all encode the same isoform (2).
    Source sequence(s)
    AC121593, AC164642
    Consensus CDS
    CCDS20372.1
    UniProtKB/Swiss-Prot
    P49117, P55093
    UniProtKB/TrEMBL
    Q3U015, Q3ZAS1
    Related
    ENSMUSP00000109087.2, ENSMUST00000113460.8
    Conserved Domains (2) summary
    cd06952
    Location:361 → 582
    NR_LBD_TR2_like; The ligand binding domain of the orphan nuclear receptors TR4 and TR2
    cd06967
    Location:112 → 198
    NR_DBD_TR2_like; DNA-binding domain of the TR2 and TR4 (human testicular receptor 2 and 4) is composed of two C4-type zinc fingers

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    92068426..92150039
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017321518.1 → XP_017177007.1  nuclear receptor subfamily 2 group C member 2 isoform X3

    UniProtKB/TrEMBL
    Q5DTL3
    Conserved Domains (2) summary
    cd06952
    Location:182 → 403
    NR_LBD_TR2_like; The ligand binding domain of the orphan nuclear receptors TR4 and TR2
    cl02596
    Location:1 → 19
    NR_DBD_like; DNA-binding domain of nuclear receptors is composed of two C4-type zinc fingers
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P49117.1 GenPept UniProtKB/Swiss-Prot:P49117

Gene LinkOut

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