Tnfrsf10b tumor necrosis factor receptor superfamily, member 10b [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Tnfrsf10bprovided by MGI
Official Full Name: tumor necrosis factor receptor superfamily, member 10bprovided by MGI
Primary source: MGI:MGI:1341090
See related: Ensembl:ENSMUSG00000022074 AllianceGenome:MGI:1341090
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: MK; DR5; Ly98; KILLER; TRICKB; TRAILR2; TRICK2A; TRICK2B
Summary: Predicted to enable TRAIL receptor activity; identical protein binding activity; and protease binding activity. Predicted to be involved in TRAIL-activated apoptotic signaling pathway; intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress; and positive regulation of apoptotic process. Predicted to act upstream of or within apoptotic process and regulation of apoptotic process. Predicted to be located in Golgi apparatus; cytosol; and membrane raft. Predicted to be active in cell surface and plasma membrane. Is expressed in bladder; liver; renal vasculature; urethra of female; and urethra of male. Human ortholog(s) of this gene implicated in carcinoma (multiple); cervical cancer; hematologic cancer (multiple); and urinary bladder cancer. Orthologous to several human genes including TNFRSF10A (TNF receptor superfamily member 10a) and TNFRSF10B (TNF receptor superfamily member 10b). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in limb E14.5 (RPKM 3.6), subcutaneous fat pad adult (RPKM 3.3) and 25 other tissues See more
Orthologs: human all
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Genomic context

Location:: 14 D2; 14 36.1 cM

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	14	NC_000080.7 (70004921..70021860)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	14	NC_000080.6 (69767472..69784411)

Chromosome 14 - NC_000080.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Death receptor 5 is required for intestinal stem cell activity during intestinal epithelial renewal at homoeostasis.
Title: Death receptor 5 is required for intestinal stem cell activity during intestinal epithelial renewal at homoeostasis.
A renal YY1-KIM1-DR5 axis regulates the progression of acute kidney injury.
Title: A renal YY1-KIM1-DR5 axis regulates the progression of acute kidney injury.
TNFRSF10B is involved in motor dysfunction in Parkinson's disease by regulating exosomal alpha-synuclein secretion from microglia.
Title: TNFRSF10B is involved in motor dysfunction in Parkinson's disease by regulating exosomal α-synuclein secretion from microglia.
TRAIL-R Deficient Mice Are Protected from Neurotoxic Effects of Amyloid-beta.
Title: TRAIL-R Deficient Mice Are Protected from Neurotoxic Effects of Amyloid-β.
TRAIL induces proliferation in rodent pancreatic beta cells via AKT activation.
Title: TRAIL induces proliferation in rodent pancreatic beta cells via AKT activation.
Soluble Fas ligand drives autoantibody-induced arthritis by binding to DR5/TRAIL-R2.
Title: Soluble Fas ligand drives autoantibody-induced arthritis by binding to DR5/TRAIL-R2.
DR5 does not promote apoptosis but acts through non-canonical MMP-EGFR-ERK1/2 signaling mechanisms to contribute to cardiomyocyte hypertrophy.
Title: Death receptor 5 contributes to cardiomyocyte hypertrophy through epidermal growth factor receptor transactivation.
Endoplasmic reticulum stress activated by hyperandrogenism in polycystic ovary syndrome promotes apoptosis of granulosa cells of antral follicles via induction of DR5.
Title: Endoplasmic Reticulum Stress Activated by Androgen Enhances Apoptosis of Granulosa Cells via Induction of Death Receptor 5 in PCOS.
Targeting upregulated DR5 in alpha-SMA-expressing dermal myofibroblasts is a viable therapy for fibrosis in scleroderma.
Title: Targeting of dermal myofibroblasts through death receptor 5 arrests fibrosis in mouse models of scleroderma.
TRAIL/TRAIL-R interaction regulates CD4(+) T cell activation in autoimmune inflammation and directly suppresses T cell activation via inhibiting TCR signaling, suggesting that TRAIL-R serves as a novel immune checkpoint in T cell responses.
Title: TRAIL-Mediated Suppression of T Cell Receptor Signaling Inhibits T Cell Activation and Inflammation in Experimental Autoimmune Encephalomyelitis.

Submit: New GeneRIF Correction See all GeneRIFs (36)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (6)
Targeted (5) 1 citation

General gene information

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Markers

px-31f3 (e-PCR)
- UniSTS:257585

D10Mit157.2 (e-PCR), detects polymorphism
- UniSTS:126061

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables TRAIL binding	RCA inferred from Reviewed Computational Analysis more info	PubMed
enables TRAIL receptor activity	ISO Inferred from Sequence Orthology more info
enables cysteine-type endopeptidase activator activity involved in apoptotic process	RCA inferred from Reviewed Computational Analysis more info	PubMed
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables protease binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in TRAIL-activated apoptotic signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within apoptotic process	RCA inferred from Reviewed Computational Analysis more info	PubMed
involved_in extrinsic apoptotic signaling pathway via death domain receptors	ISO Inferred from Sequence Orthology more info
involved_in intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of multicellular organismal process	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of apoptotic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within regulation of apoptotic process	RCA inferred from Reviewed Computational Analysis more info	PubMed
involved_in response to endoplasmic reticulum stress	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
is_active_in cell surface	IBA Inferred from Biological aspect of Ancestor more info
located_in cell surface	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in membrane raft	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: tumor necrosis factor receptor superfamily member 10B

Names: KILLER/DR5 TRAIL death-inducing receptor; death receptor 5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_020275.4 → NP_064671.2 tumor necrosis factor receptor superfamily member 10B precursor

See identical proteins and their annotated locations for NP_064671.2

Status: VALIDATED

Source sequence(s)

AK050753, BC065141

Consensus CDS

CCDS27243.1

UniProtKB/Swiss-Prot

Q6GSD9, Q9JJL5, Q9JJL6, Q9QZM4

Related

ENSMUSP00000022663.6, ENSMUST00000022663.7

Conserved Domains (2) summary

cd08315
Location:276 → 362

Death_TRAILR_DR4_DR5; Death domain of Tumor necrosis factor-Related Apoptosis-Inducing Ligand Receptors

cd10580
Location:70 → 170

TNFRSF10; Tumor necrosis factor receptor superfamily member 10 (TNFRSF10), includes TNFRSF10A (DR4), TNFRSF10B (DR5), TNFRSF10C (DcR1) and TNFRSF10D (DcR2)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000080.7 Reference GRCm39 C57BL/6J

Range

70004921..70021860

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036158575.1 → XP_036014468.1 tumor necrosis factor receptor superfamily member 10B isoform X1

Conserved Domains (1) summary

cd10580
Location:70 → 170

TNFRSF10; Tumor necrosis factor receptor superfamily member 10 (TNFRSF10), includes TNFRSF10A (DR4), TNFRSF10B (DR5), TNFRSF10C (DcR1) and TNFRSF10D (DcR2)