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Timm17b translocase of inner mitochondrial membrane 17b [ Mus musculus (house mouse) ]

Gene ID: 21855, updated on 27-Nov-2024

Summary

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Official Symbol
Timm17bprovided by MGI
Official Full Name
translocase of inner mitochondrial membrane 17bprovided by MGI
Primary source
MGI:MGI:1343176
See related
Ensembl:ENSMUSG00000031158 AllianceGenome:MGI:1343176
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Sfc3; 17kDa; mTim17b
Summary
Predicted to contribute to protein transmembrane transporter activity. Predicted to be involved in protein import into mitochondrial matrix. Located in mitochondrial inner membrane. Orthologous to human TIMM17B (translocase of inner mitochondrial membrane 17B). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in adrenal adult (RPKM 27.9), ovary adult (RPKM 20.0) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Timm17b in Genome Data Viewer
Location:
X A1.1; X 3.56 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (7765575..7773891)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (7899336..7907652)

Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene solute carrier family 35 (UDP-galactose transporter), member A2 Neighboring gene STARR-positive B cell enhancer ABC_E7684 Neighboring gene polyglutamine binding protein 1 Neighboring gene proprotein convertase subtilisin/kexin type 1 inhibitor Neighboring gene STARR-seq mESC enhancer starr_46677 Neighboring gene ES cell-expressed Ras Neighboring gene histone deacetylase 6 Neighboring gene STARR-seq mESC enhancer starr_46678 Neighboring gene STARR-seq mESC enhancer starr_46679

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Genetic and structural characterization of the human mitochondrial inner membrane translocase. Bauer MF, et al. J Mol Biol, 1999 May 28. PMID 10339406
  2. A transcript map of a 2-Mb BAC contig in the proximal portion of the mouse X chromosome and regional mapping of the scurfy mutation. Means GD, et al. Genomics, 2000 May 1. PMID 10857745
  3. The splicing regulators Esrp1 and Esrp2 direct an epithelial splicing program essential for mammalian development. Bebee TW, et al. Elife, 2015 Sep 15. PMID 26371508, Free PMC Article
  4. Proteomic analysis of the mouse liver mitochondrial inner membrane. Da Cruz S, et al. J Biol Chem, 2003 Oct 17. PMID 12865426
  5. An Interaction Landscape of Ubiquitin Signaling. Zhang X, et al. Mol Cell, 2017 Mar 2. PMID 28190767

See all (23) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
contributes_to protein transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in protein import into mitochondrial matrix IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein import into mitochondrial matrix IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of TIM23 mitochondrial import inner membrane translocase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of TIM23 mitochondrial import inner membrane translocase complex IEA
Inferred from Electronic Annotation
more info
  
part_of TIM23 mitochondrial import inner membrane translocase complex ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrial inner membrane HDA PubMed 
located_in mitochondrial inner membrane ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrion HDA PubMed 

General protein information

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Preferred Names
mitochondrial import inner membrane translocase subunit Tim17-B
Names
translocator of inner mitochondrial membrane 17 kDa, b
translocator of inner mitochondrial membrane 17b
translocator of inner mitochondrial membrane b

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001313693.1 → NP_001300622.1  mitochondrial import inner membrane translocase subunit Tim17-B isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate first exon in place of that of variant 1. This difference causes translation initiation at a downstream AUG and results in an isoform (2) with a shorter N-terminus compared to isoform 1.
    Source sequence(s)
    AK049584, AL670169, W46058
    UniProtKB/TrEMBL
    Q3UBR8
    Conserved Domains (1) summary
    cl02381
    Location:1 → 149
    Tim17; Tim17/Tim22/Tim23/Pmp24 family

  2. NM_011591.5 → NP_035721.1  mitochondrial import inner membrane translocase subunit Tim17-B isoform 1

    See identical proteins and their annotated locations for NP_035721.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AK049584, AL670169, AL671978
    Consensus CDS
    CCDS29978.1
    UniProtKB/Swiss-Prot
    Q9Z0V7
    UniProtKB/TrEMBL
    Q3UBR8, Q545H3
    Related
    ENSMUSP00000033498.4, ENSMUST00000033498.11
    Conserved Domains (1) summary
    cl02381
    Location:1 → 171
    Tim17; Tim17/Tim22/Tim23/Pmp24 family

RNA

  1. NR_132589.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an alternate exon compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AK049584, AL670169, AL671978, BY294049

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000086.8 Reference GRCm39 C57BL/6J

    Range
    7765575..7773891
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9Z0V7.1 GenPept UniProtKB/Swiss-Prot:Q9Z0V7

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
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