Rab40b Rab40B, member RAS oncogene family [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Rab40bprovided by MGI
Official Full Name: Rab40B, member RAS oncogene familyprovided by MGI
Primary source: MGI:MGI:2183451
See related: Ensembl:ENSMUSG00000025170 AllianceGenome:MGI:2183451
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: rar; SEC4L
Summary: Predicted to enable GTPase activity. Predicted to be involved in exocytosis. Predicted to be located in mitochondrion; nuclear envelope; and perinuclear region of cytoplasm. Predicted to be active in endosome; plasma membrane; and synaptic vesicle. Predicted to colocalize with Golgi apparatus and lipid droplet. Orthologous to several human genes including RAB40B (RAB40B, member RAS oncogene family). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Broad expression in frontal lobe adult (RPKM 12.0), cortex adult (RPKM 7.4) and 17 other tissues See more
Orthologs: human all
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Genomic context

Location:: 11 E2; 11 85.28 cM

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	11	NC_000077.7 (121246951..121279080, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (121356121..121388251, complement)

Chromosome 11 - NC_000077.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

This is the first study that identifies a new Rab40b-Tks5- and miR-204-dependent invadopodia transport pathway that regulates MMP2 and MMP9 secretion, and extracellular matrix remodeling during cancer progression.
Title: Rab40b and Tks5 interact at invadopodia during metastasis.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables GTP binding	IEA Inferred from Electronic Annotation more info
enables GTPase activity	IBA Inferred from Biological aspect of Ancestor more info
enables GTPase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in cellular detoxification	IEA Inferred from Electronic Annotation more info
involved_in exocytosis	IBA Inferred from Biological aspect of Ancestor more info
involved_in intracellular signal transduction	IEA Inferred from Electronic Annotation more info
involved_in protein ubiquitination	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
colocalizes_with Golgi apparatus	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in endosome	IBA Inferred from Biological aspect of Ancestor more info
colocalizes_with lipid droplet	ISO Inferred from Sequence Orthology more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info
located_in nuclear envelope	IEA Inferred from Electronic Annotation more info
located_in nuclear envelope	ISO Inferred from Sequence Orthology more info
located_in perinuclear region of cytoplasm	IEA Inferred from Electronic Annotation more info
located_in perinuclear region of cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
is_active_in synaptic vesicle	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: ras-related protein Rab-40B

Names: RAR SOCS box containing protein; SOCS box-containing protein RAR

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001404682.1 → NP_001391611.1 ras-related protein Rab-40B isoform 1

Status: VALIDATED

Source sequence(s)

AL663088
NM_139147.4 → NP_631886.3 ras-related protein Rab-40B isoform 2

Status: VALIDATED

Source sequence(s)

AL663088

Consensus CDS

CCDS25774.2

UniProtKB/Swiss-Prot

Q8VHP8

UniProtKB/TrEMBL

Q4VA07

Related

ENSMUSP00000101713.4, ENSMUST00000106107.3