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Tmc6 transmembrane channel-like gene family 6 [ Mus musculus (house mouse) ]

Gene ID: 217353, updated on 27-Nov-2024

Summary

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Official Symbol
Tmc6provided by MGI
Official Full Name
transmembrane channel-like gene family 6provided by MGI
Primary source
MGI:MGI:1098686
See related
Ensembl:ENSMUSG00000025572 AllianceGenome:MGI:1098686
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
EVER1; D11Ertd204e
Summary
Predicted to enable mechanosensitive monoatomic ion channel activity. Involved in protein stabilization. Predicted to be located in Golgi apparatus; endoplasmic reticulum; and nuclear membrane. Human ortholog(s) of this gene implicated in epidermodysplasia verruciformis. Orthologous to human TMC6 (transmembrane channel like 6). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Broad expression in thymus adult (RPKM 37.8), spleen adult (RPKM 30.5) and 20 other tissues See more
Orthologs
human all
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Genomic context

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See Tmc6 in Genome Data Viewer
Location:
11 E2; 11 82.96 cM
Exon count:
29
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (117656811..117673019, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (117765985..117782193, complement)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 2900041M22 gene Neighboring gene predicted gene, 35170 Neighboring gene STARR-seq mESC enhancer starr_31269 Neighboring gene STARR-positive B cell enhancer ABC_E2377 Neighboring gene STARR-positive B cell enhancer ABC_E5303 Neighboring gene trinucleotide repeat containing 6C Neighboring gene STARR-seq mESC enhancer starr_31271 Neighboring gene STARR-seq mESC enhancer starr_31272 Neighboring gene STARR-positive B cell enhancer ABC_E1437 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:117642510-117642724 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:117643420-117643529 Neighboring gene STARR-positive B cell enhancer ABC_E5304 Neighboring gene STARR-positive B cell enhancer ABC_E9147 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:117655547-117655805 Neighboring gene RIKEN cDNA 6030468B19 gene Neighboring gene predicted gene 11723 Neighboring gene STARR-positive B cell enhancer ABC_E5305 Neighboring gene transmembrane channel-like gene family 8

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Expression of a TMC6-TMC8-CIB1 heterotrimeric complex in lymphocytes is regulated by each of the components. Wu CJ, et al. J Biol Chem, 2020 Nov 20. PMID 32917726, Free PMC Article
  2. Characterization of the transmembrane channel-like (TMC) gene family: functional clues from hearing loss and epidermodysplasia verruciformis. Kurima K, et al. Genomics, 2003 Sep. PMID 12906855
  3. TMC and EVER genes belong to a larger novel family, the TMC gene family encoding transmembrane proteins. Keresztes G, et al. BMC Genomics, 2003 Jun 17. PMID 12812529, Free PMC Article
  4. Novel skin phenotypes revealed by a genome-wide mouse reverse genetic screen. Liakath-Ali K, et al. Nat Commun, 2014 Apr 11. PMID 24721909, Free PMC Article
  5. Construction of a multi-functional cDNA library specific for mouse pancreatic islets and its application to microarray. Nishimura M, et al. DNA Res, 2004 Oct 31. PMID 15747579

See all (24) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Expression of a TMC6-TMC8-CIB1 heterotrimeric complex in lymphocytes is regulated by each of the components.
    Title: Expression of a TMC6-TMC8-CIB1 heterotrimeric complex in lymphocytes is regulated by each of the components.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Targeted (2)  1 citation

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables mechanosensitive monoatomic ion channel activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in intracellular zinc ion homeostasis ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in protein stabilization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
  
located_in nuclear membrane ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
transmembrane channel-like protein 6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_145439.3 → NP_663414.3  transmembrane channel-like protein 6

    See identical proteins and their annotated locations for NP_663414.3

    Status: VALIDATED

    Source sequence(s)
    AK052814, AL645856, AY263158, BP767442
    Consensus CDS
    CCDS25687.1
    UniProtKB/Swiss-Prot
    B1ATB4, Q78JR7, Q7TN60, Q7TQ68, Q8BP52, Q8C6Z5, Q99J32
    UniProtKB/TrEMBL
    B1ATB3
    Related
    ENSMUSP00000026659.4, ENSMUST00000026659.10
    Conserved Domains (1) summary
    pfam07810
    Location:539 → 645
    TMC; TMC domain

RNA

  1. NR_154387.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AK077671, AL645856, BP767442
    Related
    ENSMUST00000131606.8

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    117656811..117673019 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006533115.2 → XP_006533178.1  transmembrane channel-like protein 6 isoform X1

    See identical proteins and their annotated locations for XP_006533178.1

    UniProtKB/Swiss-Prot
    B1ATB4, Q78JR7, Q7TN60, Q7TQ68, Q8BP52, Q8C6Z5, Q99J32
    UniProtKB/TrEMBL
    B1ATB3
    Conserved Domains (1) summary
    pfam07810
    Location:539 → 645
    TMC; TMC domain

  2. XM_006533116.2 → XP_006533179.1  transmembrane channel-like protein 6 isoform X1

    See identical proteins and their annotated locations for XP_006533179.1

    UniProtKB/Swiss-Prot
    B1ATB4, Q78JR7, Q7TN60, Q7TQ68, Q8BP52, Q8C6Z5, Q99J32
    UniProtKB/TrEMBL
    B1ATB3
    Conserved Domains (1) summary
    pfam07810
    Location:539 → 645
    TMC; TMC domain

  3. XM_006533114.5 → XP_006533177.1  transmembrane channel-like protein 6 isoform X1

    See identical proteins and their annotated locations for XP_006533177.1

    UniProtKB/Swiss-Prot
    B1ATB4, Q78JR7, Q7TN60, Q7TQ68, Q8BP52, Q8C6Z5, Q99J32
    UniProtKB/TrEMBL
    B1ATB3
    Conserved Domains (1) summary
    pfam07810
    Location:539 → 645
    TMC; TMC domain

  4. XM_006533118.5 → XP_006533181.1  transmembrane channel-like protein 6 isoform X3

    See identical proteins and their annotated locations for XP_006533181.1

    UniProtKB/Swiss-Prot
    B1ATB4, Q78JR7, Q7TN60, Q7TQ68, Q8BP52, Q8C6Z5, Q99J32
    Conserved Domains (1) summary
    pfam07810
    Location:491 → 597
    TMC; TMC domain

  5. XM_006533117.5 → XP_006533180.1  transmembrane channel-like protein 6 isoform X2

    UniProtKB/Swiss-Prot
    B1ATB4, Q78JR7, Q7TN60, Q7TQ68, Q8BP52, Q8C6Z5, Q99J32
    Conserved Domains (1) summary
    pfam07810
    Location:535 → 641
    TMC; TMC domain

  6. XM_006533112.5 → XP_006533175.1  transmembrane channel-like protein 6 isoform X1

    See identical proteins and their annotated locations for XP_006533175.1

    UniProtKB/Swiss-Prot
    B1ATB4, Q78JR7, Q7TN60, Q7TQ68, Q8BP52, Q8C6Z5, Q99J32
    UniProtKB/TrEMBL
    B1ATB3
    Conserved Domains (1) summary
    pfam07810
    Location:539 → 645
    TMC; TMC domain

  7. XM_030245908.2 → XP_030101768.1  transmembrane channel-like protein 6 isoform X2

    UniProtKB/Swiss-Prot
    B1ATB4, Q78JR7, Q7TN60, Q7TQ68, Q8BP52, Q8C6Z5, Q99J32
    Conserved Domains (1) summary
    pfam07810
    Location:535 → 641
    TMC; TMC domain

  8. XM_006533113.5 → XP_006533176.1  transmembrane channel-like protein 6 isoform X1

    See identical proteins and their annotated locations for XP_006533176.1

    UniProtKB/Swiss-Prot
    B1ATB4, Q78JR7, Q7TN60, Q7TQ68, Q8BP52, Q8C6Z5, Q99J32
    UniProtKB/TrEMBL
    B1ATB3
    Conserved Domains (1) summary
    pfam07810
    Location:539 → 645
    TMC; TMC domain

  9. XM_006533119.5 → XP_006533182.1  transmembrane channel-like protein 6 isoform X3

    See identical proteins and their annotated locations for XP_006533182.1

    UniProtKB/Swiss-Prot
    B1ATB4, Q78JR7, Q7TN60, Q7TQ68, Q8BP52, Q8C6Z5, Q99J32
    Conserved Domains (1) summary
    pfam07810
    Location:491 → 597
    TMC; TMC domain

  10. XM_030245907.2 → XP_030101767.1  transmembrane channel-like protein 6 isoform X2

    UniProtKB/Swiss-Prot
    B1ATB4, Q78JR7, Q7TN60, Q7TQ68, Q8BP52, Q8C6Z5, Q99J32
    Conserved Domains (1) summary
    pfam07810
    Location:535 → 641
    TMC; TMC domain

  11. XM_006533120.4 → XP_006533183.1  transmembrane channel-like protein 6 isoform X4

    Conserved Domains (1) summary
    pfam07810
    Location:539 → 638
    TMC; TMC domain

  12. XM_006533122.5 → XP_006533185.1  transmembrane channel-like protein 6 isoform X5

RNA

  1. XR_004936931.1 RNA Sequence

  2. XR_004936932.1 RNA Sequence

  3. XR_003949405.2 RNA Sequence

  4. XR_388423.5 RNA Sequence

  5. XR_003949404.2 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_181321.3: Suppressed sequence

    Description
    NM_181321.3: This RefSeq was removed because currently there is insufficient support for the transcript and protein.
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q7TN60.2 GenPept UniProtKB/Swiss-Prot:Q7TN60

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