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Llgl2 LLGL2 scribble cell polarity complex component [ Mus musculus (house mouse) ]

Gene ID: 217325, updated on 27-Nov-2024

Summary

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Official Symbol
Llgl2provided by MGI
Official Full Name
LLGL2 scribble cell polarity complex componentprovided by MGI
Primary source
MGI:MGI:1918843
See related
Ensembl:ENSMUSG00000020782 AllianceGenome:MGI:1918843
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Llglh2; 9130006H11Rik
Summary
Predicted to enable GTPase activator activity; PDZ domain binding activity; and myosin II binding activity. Acts upstream of or within establishment or maintenance of polarity of embryonic epithelium; labyrinthine layer development; and post-embryonic development. Predicted to be located in cytosol and intracellular membrane-bounded organelle. Predicted to be active in cortical actin cytoskeleton and plasma membrane. Is expressed in several structures, including cardiovascular system; endocrine gland; genitourinary system; gut; and nasal cavity epithelium. Orthologous to human LLGL2 (LLGL scribble cell polarity complex component 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Broad expression in colon adult (RPKM 75.1), duodenum adult (RPKM 44.0) and 16 other tissues See more
Orthologs
human all
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Genomic context

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See Llgl2 in Genome Data Viewer
Location:
11 E2; 11 80.91 cM
Exon count:
28
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (115714855..115746606)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (115824029..115855780)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene transmembrane protein 94 Neighboring gene CASK-interacting protein 2 Neighboring gene STARR-positive B cell enhancer ABC_E3039 Neighboring gene tRNA splicing endonuclease subunit 54 Neighboring gene STARR-seq mESC enhancer starr_31175 Neighboring gene STARR-seq mESC enhancer starr_31178 Neighboring gene myosin XVB Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:115759828-115760025 Neighboring gene RecQ protein-like 5 Neighboring gene small integral membrane protein 5

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. The tumor suppressor Lgl1 regulates NMII-A cellular distribution and focal adhesion morphology to optimize cell migration. Dahan I, et al. Mol Biol Cell, 2012 Feb. PMID 22219375, Free PMC Article
  2. Scribble1 plays an important role in the pathogenesis of neural tube defects through its mediating effect of Par-3 and Vangl1/2 localization. Kharfallah F, et al. Hum Mol Genet, 2017 Jun 15. PMID 28369449
  3. MARCKS modulates radial progenitor placement, proliferation and organization in the developing cerebral cortex. Weimer JM, et al. Development, 2009 Sep. PMID 19666823, Free PMC Article
  4. Mammalian Llgl2 is necessary for proper branching morphogenesis during placental development. Sripathy S, et al. Mol Cell Biol, 2011 Jul. PMID 21606200, Free PMC Article
  5. Loss of cell polarity causes severe brain dysplasia in Lgl1 knockout mice. Klezovitch O, et al. Genes Dev, 2004 Mar 1. PMID 15037549, Free PMC Article

See all (28) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 
  • Gene trapped (2) 
  • Targeted (2) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC27928

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables GTPase activator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables PDZ domain binding ISO
Inferred from Sequence Orthology
more info
  
enables myosin II binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in Golgi to plasma membrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in L-leucine transport ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within branching involved in labyrinthine layer morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cell division IEA
Inferred from Electronic Annotation
more info
  
involved_in cortical actin cytoskeleton organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in establishment of spindle orientation IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within establishment or maintenance of polarity of embryonic epithelium IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in exocytosis IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within labyrinthine layer blood vessel development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within multicellular organism growth IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within placenta development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within post-embryonic development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of Notch signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of establishment or maintenance of cell polarity IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of establishment or maintenance of cell polarity ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in cortical actin cytoskeleton IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
LLGL scribble cell polarity complex component 2
Names
lethal giant larvae-like protein 2
lethal(2) giant larvae protein homolog 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001252532.1 → NP_001239461.1  LLGL scribble cell polarity complex component 2 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) has an alternate splice site in the central coding region, which does not affect the reading frame, compared to variant 1. The resulting isoform (2) has an additional segment, compared to isoform 1.
    Source sequence(s)
    AK078901, AK143486, AY033650, BY200843
    Consensus CDS
    CCDS56820.1
    UniProtKB/TrEMBL
    J3QJU5
    Related
    ENSMUSP00000136054.2, ENSMUST00000177736.8
    Conserved Domains (3) summary
    COG2319
    Location:36 → 267
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:35 → 67
    7WD40; WD40 repeat [structural motif]
    pfam08366
    Location:271 → 371
    LLGL; LLGL2

  2. NM_145438.2 → NP_663413.2  LLGL scribble cell polarity complex component 2 isoform 1

    See identical proteins and their annotated locations for NP_663413.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) is the predominant transcript and encodes a shorter isoform (1).
    Source sequence(s)
    AK078901, AK167536, BE982097, BY200843
    Consensus CDS
    CCDS25649.1
    UniProtKB/Swiss-Prot
    B1ATB0, Q3TJ91, Q6YP20, Q8K1X0
    Related
    ENSMUSP00000099321.5, ENSMUST00000103032.11
    Conserved Domains (3) summary
    COG2319
    Location:36 → 267
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:35 → 67
    7WD40; WD40 repeat [structural motif]
    pfam08366
    Location:271 → 371
    LLGL; LLGL2

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    115714855..115746606
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030245894.1 → XP_030101754.1  LLGL scribble cell polarity complex component 2 isoform X1

    Conserved Domains (3) summary
    COG2319
    Location:36 → 267
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:35 → 67
    7WD40; WD40 repeat [structural motif]
    pfam08366
    Location:271 → 371
    LLGL; LLGL2

  2. XM_006533083.2 → XP_006533146.1  LLGL scribble cell polarity complex component 2 isoform X1

    Conserved Domains (3) summary
    COG2319
    Location:36 → 267
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:35 → 67
    7WD40; WD40 repeat [structural motif]
    pfam08366
    Location:271 → 371
    LLGL; LLGL2

  3. XM_006533084.2 → XP_006533147.1  LLGL scribble cell polarity complex component 2 isoform X2

    Conserved Domains (3) summary
    COG2319
    Location:36 → 267
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:35 → 67
    7WD40; WD40 repeat [structural motif]
    pfam08366
    Location:271 → 371
    LLGL; LLGL2

  4. XM_006533085.2 → XP_006533148.1  LLGL scribble cell polarity complex component 2 isoform X3

    Conserved Domains (3) summary
    COG2319
    Location:36 → 267
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:35 → 67
    7WD40; WD40 repeat [structural motif]
    pfam08366
    Location:271 → 371
    LLGL; LLGL2

  5. XM_006533087.2 → XP_006533150.1  LLGL scribble cell polarity complex component 2 isoform X5

    Conserved Domains (3) summary
    COG2319
    Location:36 → 267
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:35 → 67
    7WD40; WD40 repeat [structural motif]
    pfam08366
    Location:271 → 371
    LLGL; LLGL2

  6. XM_006533086.4 → XP_006533149.1  LLGL scribble cell polarity complex component 2 isoform X4

    Conserved Domains (3) summary
    COG2319
    Location:36 → 267
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:35 → 67
    7WD40; WD40 repeat [structural motif]
    pfam08366
    Location:271 → 371
    LLGL; LLGL2

  7. XM_030245895.1 → XP_030101755.1  LLGL scribble cell polarity complex component 2 isoform X1

    Conserved Domains (3) summary
    COG2319
    Location:36 → 267
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:35 → 67
    7WD40; WD40 repeat [structural motif]
    pfam08366
    Location:271 → 371
    LLGL; LLGL2

RNA

  1. XR_388421.2 RNA Sequence

  2. XR_388422.3 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q3TJ91.2 GenPept UniProtKB/Swiss-Prot:Q3TJ91

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