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Abca8a ATP-binding cassette, sub-family A member 8a [ Mus musculus (house mouse) ]

Gene ID: 217258, updated on 27-Nov-2024

Summary

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Official Symbol
Abca8aprovided by MGI
Official Full Name
ATP-binding cassette, sub-family A member 8aprovided by MGI
Primary source
MGI:MGI:2386846
See related
Ensembl:ENSMUSG00000041828 AllianceGenome:MGI:2386846
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Predicted to enable ABC-type xenobiotic transporter activity and lipid transporter activity. Predicted to be involved in several processes, including cholesterol efflux; positive regulation of cholesterol efflux; and sphingomyelin biosynthetic process. Predicted to be located in basolateral plasma membrane and endoplasmic reticulum. Predicted to be active in intracellular membrane-bounded organelle. Is expressed in telencephalon. Orthologous to human ABCA8 (ATP binding cassette subfamily A member 8). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in liver E18 (RPKM 13.1), bladder adult (RPKM 9.6) and 13 other tissues See more
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Genomic context

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See Abca8a in Genome Data Viewer
Location:
11 E1; 11 73.07 cM
Exon count:
41
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (109916460..109988403, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (110025634..110097580, complement)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 39444 Neighboring gene ATP-binding cassette, sub-family A member 8b Neighboring gene STARR-seq mESC enhancer starr_31033 Neighboring gene ATP-binding cassette, sub-family A member 9 Neighboring gene ATP-binding cassette, sub-family A member 6

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. ABCA8 Regulates Cholesterol Efflux and High-Density Lipoprotein Cholesterol Levels. Trigueros-Motos L, et al. Arterioscler Thromb Vasc Biol, 2017 Nov. PMID 28882873
  2. Molecular cloning of a mouse scavenger receptor with C-type lectin (SRCL)(1), a novel member of the scavenger receptor family. Nakamura K, et al. Biochim Biophys Acta, 2001 Nov 11. PMID 11718900
  3. Acute digoxin loading reduces ABCA8A mRNA expression in the mouse liver. Wakaumi M, et al. Clin Exp Pharmacol Physiol, 2005 Dec. PMID 16445568
  4. Evolutionary analysis of a cluster of ATP-binding cassette (ABC) genes. Annilo T, et al. Mamm Genome, 2003 Jan. PMID 12532264
  5. Decreased expression levels of Ifi genes is associated to the increased resistance to spontaneous arthritis disease in mice deficiency of IL-1RA. Liu X, et al. BMC Immunol, 2016 Aug 2. PMID 27480124, Free PMC Article

See all (22) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. ABCA8 facilitates cholesterol efflux and modulates HDL-cholesterol levels.
    Title: ABCA8 Regulates Cholesterol Efflux and High-Density Lipoprotein Cholesterol Levels.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Targeted (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ABC-type transporter activity ISO
Inferred from Sequence Orthology
more info
  
enables ABC-type transporter activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables ABC-type xenobiotic transporter activity ISO
Inferred from Sequence Orthology
more info
  
enables ABC-type xenobiotic transporter activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
  
enables ATPase-coupled transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables lipid transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in cholesterol efflux ISO
Inferred from Sequence Orthology
more info
  
involved_in cholesterol efflux ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in cholesterol transport ISO
Inferred from Sequence Orthology
more info
  
involved_in cholesterol transport ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in lipid transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of cholesterol efflux ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of cholesterol efflux ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of cholesterol efflux ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of cholesterol efflux ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in sphingomyelin biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in sphingomyelin biosynthetic process ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in xenobiotic transport ISO
Inferred from Sequence Orthology
more info
  
involved_in xenobiotic transport ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in basolateral plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  
located_in endoplasmic reticulum ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in intracellular membrane-bounded organelle IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
ABC-type organic anion transporter ABCA8A
Names
ATP-binding cassette sub-family A member 8-A
ATP-binding cassette, sub-family A (ABC1), member 8a

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001405146.1 → NP_001392075.1  ABC-type organic anion transporter ABCA8A isoform 3

    Status: VALIDATED

    Source sequence(s)
    AL603792, AL662821

  2. NM_001405147.1 → NP_001392076.1  ABC-type organic anion transporter ABCA8A isoform 1

    Status: VALIDATED

    Source sequence(s)
    AL603792, AL662821

  3. NM_001405148.1 → NP_001392077.1  ABC-type organic anion transporter ABCA8A isoform 1

    Status: VALIDATED

    Source sequence(s)
    AL603792, AL662821
    Related
    ENSMUSP00000097860.3, ENSMUST00000100287.9

  4. NM_001405149.1 → NP_001392078.1  ABC-type organic anion transporter ABCA8A isoform 1

    Status: VALIDATED

    Source sequence(s)
    AL603792, AL662821

  5. NM_001405150.1 → NP_001392079.1  ABC-type organic anion transporter ABCA8A isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL603792, AL662821

  6. NM_153145.5 → NP_694785.3  ABC-type organic anion transporter ABCA8A isoform 1

    See identical proteins and their annotated locations for NP_694785.3

    Status: VALIDATED

    Source sequence(s)
    AL603792, AL662821
    Consensus CDS
    CCDS48974.1
    UniProtKB/TrEMBL
    A4PBQ7
    Conserved Domains (1) summary
    TIGR01257
    Location:224 → 1596
    rim_protein; retinal-specific rim ABC transporter

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    109916460..109988403 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006533061.3 → XP_006533124.3  ABC-type organic anion transporter ABCA8A isoform X1

    UniProtKB/TrEMBL
    A4PBQ7
    Conserved Domains (1) summary
    TIGR01257
    Location:258 → 1630
    rim_protein; retinal-specific rim ABC transporter
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8K442.2 GenPept UniProtKB/Swiss-Prot:Q8K442

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