Tada2a transcriptional adaptor 2A [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Tada2aprovided by MGI
Official Full Name: transcriptional adaptor 2Aprovided by MGI
Primary source: MGI:MGI:2144471
See related: Ensembl:ENSMUSG00000018651 AllianceGenome:MGI:2144471
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Tada2l; D030022J10Rik
Summary: Predicted to enable chromatin binding activity and transcription coactivator activity. Predicted to contribute to histone acetyltransferase activity. Involved in regulation of cell cycle; regulation of cell division; and regulation of embryonic development. Acts upstream of or within several processes, including chromatin organization; regulation of protein modification process; and regulation of protein stability. Located in mitotic spindle and nucleus. Part of ATAC complex. Orthologous to human TADA2A (transcriptional adaptor 2A). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Broad expression in CNS E11.5 (RPKM 12.3), limb E14.5 (RPKM 12.0) and 25 other tissues See more
Orthologs: human all
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Genomic context

Location:: 11 C; 11 51.29 cM

Exon count:: 17

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	11	NC_000077.7 (83969746..84020466, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (84078920..84129644, complement)

Chromosome 11 - NC_000077.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

alpha-Synuclein A53T Binds to Transcriptional Adapter 2-Alpha and Blocks Histone H3 Acetylation.
Title: α-Synuclein A53T Binds to Transcriptional Adapter 2-Alpha and Blocks Histone H3 Acetylation.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables chromatin binding	IBA Inferred from Biological aspect of Ancestor more info
contributes_to histone acetyltransferase activity	ISO Inferred from Sequence Orthology more info
enables transcription coactivator activity	IBA Inferred from Biological aspect of Ancestor more info
enables transcription coactivator activity	IEA Inferred from Electronic Annotation more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within chromatin organization	IGI Inferred from Genetic Interaction more info	PubMed
involved_in chromatin remodeling	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within mitotic cell cycle	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in regulation of DNA-templated transcription	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of DNA-templated transcription	NAS Non-traceable Author Statement more info	PubMed
involved_in regulation of cell cycle	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of cell cycle	ISO Inferred from Sequence Orthology more info
involved_in regulation of cell cycle	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of cell division	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of cell division	ISO Inferred from Sequence Orthology more info
involved_in regulation of cell division	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of embryonic development	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of embryonic development	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within regulation of protein phosphorylation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of protein stability	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in regulation of transcription by RNA polymerase II	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within regulation of tubulin deacetylation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of tubulin deacetylation	ISO Inferred from Sequence Orthology more info
involved_in regulation of tubulin deacetylation	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
part_of ATAC complex	IDA Inferred from Direct Assay more info	PubMed
part_of ATAC complex	ISO Inferred from Sequence Orthology more info
part_of SAGA complex	ISO Inferred from Sequence Orthology more info
part_of SAGA complex	NAS Non-traceable Author Statement more info	PubMed
part_of SAGA-type complex	IBA Inferred from Biological aspect of Ancestor more info
located_in mitotic spindle	IDA Inferred from Direct Assay more info	PubMed
located_in mitotic spindle	NAS Non-traceable Author Statement more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: transcriptional adapter 2-alpha

Names: ADA2-like protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_172562.3 → NP_766150.1 transcriptional adapter 2-alpha

See identical proteins and their annotated locations for NP_766150.1

Status: PROVISIONAL

Source sequence(s)

AL596447, AL645615

Consensus CDS

CCDS25183.1

UniProtKB/Swiss-Prot

Q3TZD7, Q8BNK0, Q8CHV6, Q8R3H5

Related

ENSMUSP00000018795.7, ENSMUST00000018795.13

Conserved Domains (4) summary

COG5114
Location:11 → 440

COG5114; Histone acetyltransferase complex SAGA/ADA, subunit ADA2 [Chromatin structure and dynamics]

cd00167
Location:74 → 118

SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...

cd02335
Location:15 → 64

ZZ_ADA2; Zinc finger, ZZ type. Zinc finger present in ADA2, a putative transcriptional adaptor, and related proteins. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding.

pfam04433
Location:374 → 440

SWIRM; SWIRM domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000077.7 Reference GRCm39 C57BL/6J

Range

83969746..84020466 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006532989.5 → XP_006533052.1 transcriptional adapter 2-alpha isoform X1

Conserved Domains (1) summary

COG5114
Location:11 → 420

COG5114; Histone acetyltransferase complex SAGA/ADA, subunit ADA2 [Chromatin structure and dynamics]
XM_030245845.2 → XP_030101705.1 transcriptional adapter 2-alpha isoform X2

UniProtKB/TrEMBL

B1AT25

Conserved Domains (1) summary

COG5114
Location:1 → 276

COG5114; Histone acetyltransferase complex SAGA/ADA, subunit ADA2 [Chromatin structure and dynamics]
XM_011248932.4 → XP_011247234.1 transcriptional adapter 2-alpha isoform X3

Conserved Domains (1) summary

COG5114
Location:11 → 272

COG5114; Histone acetyltransferase complex SAGA/ADA, subunit ADA2 [Chromatin structure and dynamics]