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Mmgt2 membrane magnesium transporter 2 [ Mus musculus (house mouse) ]

Gene ID: 216829, updated on 27-Nov-2024

Summary

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Official Symbol
Mmgt2provided by MGI
Official Full Name
membrane magnesium transporter 2provided by MGI
Primary source
MGI:MGI:2448491
See related
Ensembl:ENSMUSG00000048497 AllianceGenome:MGI:2448491
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Enables magnesium ion transmembrane transporter activity and transition metal ion transmembrane transporter activity. Involved in magnesium ion transport. Acts upstream of or within transition metal ion transport. Located in Golgi apparatus; early endosome; and plasma membrane. Is expressed in several structures, including alimentary system; brain; cardiovascular system; genitourinary system; and respiratory system. [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in bladder adult (RPKM 10.2), limb E14.5 (RPKM 7.6) and 27 other tissues See more
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Genomic context

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See Mmgt2 in Genome Data Viewer
Location:
11 B2; 11 38.56 cM
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (62538999..62557185)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (62648180..62666359)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 2410006H16 gene Neighboring gene small nucleolar RNA, C/D box 65 Neighboring gene leucine rich repeat containing 75A Neighboring gene leucine rich repeat containing 75A, opposite strand 1 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:62462281-62462390 Neighboring gene zinc finger protein 287 Neighboring gene nuclear encoded tRNA trytophan 8 (anticodon CCA)

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Identification and characterization of a novel family of membrane magnesium transporters, MMgT1 and MMgT2. Goytain A, et al. Am J Physiol Cell Physiol, 2008 Feb. PMID 18057121
  2. BioID screening of biotinylation sites using the avidin-like protein Tamavidin 2-REV identifies global interactors of stimulator of interferon genes (STING). Motani K, et al. J Biol Chem, 2020 Aug 7. PMID 32554809, Free PMC Article
  3. The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data. Koscielny G, et al. Nucleic Acids Res, 2014 Jan. PMID 24194600, Free PMC Article
  4. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article
  5. Genetic determinants of micronucleus formation in vivo. Adams DJ, et al. Nature, 2024 Mar. PMID 38355793, Free PMC Article

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC36859

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables cobalt ion transmembrane transporter activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables copper ion transmembrane transporter activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables inorganic cation transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables inorganic cation transmembrane transporter activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables magnesium ion transmembrane transporter activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables magnesium ion transmembrane transporter activity TAS
Traceable Author Statement
more info
  
enables manganese ion transmembrane transporter activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables nickel cation transmembrane transporter activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within cobalt ion transport IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in copper ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within copper ion transport IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in magnesium ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within magnesium ion transport IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in magnesium ion transport IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in manganese ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within manganese ion transport IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within monoatomic cation transport IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in nickel cation transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within nickel cation transport IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
part_of EMC complex IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in Golgi apparatus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in Golgi membrane TAS
Traceable Author Statement
more info
  
is_active_in early endosome IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in early endosome IDA
Inferred from Direct Assay
more info
 PubMed 
located_in early endosome membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
membrane magnesium transporter 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_175002.2 → NP_778167.1  membrane magnesium transporter 2

    See identical proteins and their annotated locations for NP_778167.1

    Status: VALIDATED

    Source sequence(s)
    AK131977, AL596181, BB871237
    Consensus CDS
    CCDS36179.1
    UniProtKB/Swiss-Prot
    Q8R3L0
    Related
    ENSMUSP00000128697.2, ENSMUST00000155759.3
    Conserved Domains (1) summary
    pfam10270
    Location:12 → 90
    MMgT; Membrane magnesium transporter

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    62538999..62557185
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011248909.3 → XP_011247211.2  membrane magnesium transporter 2 isoform X1

  2. XM_036156560.1 → XP_036012453.1  membrane magnesium transporter 2 isoform X2

    UniProtKB/Swiss-Prot
    Q8R3L0
    Conserved Domains (1) summary
    pfam10270
    Location:12 → 90
    MMgT; Membrane magnesium transporter

  3. XM_036156556.1 → XP_036012449.1  membrane magnesium transporter 2 isoform X2

    UniProtKB/Swiss-Prot
    Q8R3L0
    Conserved Domains (1) summary
    pfam10270
    Location:12 → 90
    MMgT; Membrane magnesium transporter

  4. XM_036156558.1 → XP_036012451.1  membrane magnesium transporter 2 isoform X2

    UniProtKB/Swiss-Prot
    Q8R3L0
    Related
    ENSMUSP00000128669.2, ENSMUST00000129162.3
    Conserved Domains (1) summary
    pfam10270
    Location:12 → 90
    MMgT; Membrane magnesium transporter

  5. XM_036156557.1 → XP_036012450.1  membrane magnesium transporter 2 isoform X2

    UniProtKB/Swiss-Prot
    Q8R3L0
    Conserved Domains (1) summary
    pfam10270
    Location:12 → 90
    MMgT; Membrane magnesium transporter

  6. XM_006532870.2 → XP_006532933.1  membrane magnesium transporter 2 isoform X2

    See identical proteins and their annotated locations for XP_006532933.1

    UniProtKB/Swiss-Prot
    Q8R3L0
    Conserved Domains (1) summary
    pfam10270
    Location:12 → 90
    MMgT; Membrane magnesium transporter

  7. XM_036156559.1 → XP_036012452.1  membrane magnesium transporter 2 isoform X2

    UniProtKB/Swiss-Prot
    Q8R3L0
    Conserved Domains (1) summary
    pfam10270
    Location:12 → 90
    MMgT; Membrane magnesium transporter

  8. XM_036156555.1 → XP_036012448.1  membrane magnesium transporter 2 isoform X2

    UniProtKB/Swiss-Prot
    Q8R3L0
    Conserved Domains (1) summary
    pfam10270
    Location:12 → 90
    MMgT; Membrane magnesium transporter
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8R3L0.1 GenPept UniProtKB/Swiss-Prot:Q8R3L0

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