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Tmprss4 transmembrane protease, serine 4 [ Mus musculus (house mouse) ]

Gene ID: 214523, updated on 27-Nov-2024

Summary

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Official Symbol
Tmprss4provided by MGI
Official Full Name
transmembrane protease, serine 4provided by MGI
Primary source
MGI:MGI:2384877
See related
Ensembl:ENSMUSG00000032091 AllianceGenome:MGI:2384877
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
CAP2; mCAP2
Summary
Predicted to enable serine-type peptidase activity. Acts upstream of or within response to wounding. Located in secretory granule. Is expressed in alimentary system; olfactory epithelium; and urinary system. Orthologous to human TMPRSS4 (transmembrane serine protease 4). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in large intestine adult (RPKM 63.2), colon adult (RPKM 50.4) and 5 other tissues See more
Orthologs
human all
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Genomic context

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See Tmprss4 in Genome Data Viewer
Location:
9 A5.2; 9 24.84 cM
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (45084024..45115417, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (45172726..45204119, complement)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene sodium channel, type IV, beta Neighboring gene STARR-seq mESC enhancer starr_23992 Neighboring gene predicted gene, 39327 Neighboring gene predicted gene, 57797 Neighboring gene small integral membrane protein 35 Neighboring gene STARR-positive B cell enhancer mm9_chr9:45029701-45030002 Neighboring gene STARR-positive B cell enhancer mm9_chr9:45054121-45054422 Neighboring gene interleukin 10 receptor, alpha Neighboring gene microRNA 7086 Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:45108641-45108750 Neighboring gene brown adipose tissue enriched long noncoding RNA 3 Neighboring gene transmembrane protease, serine 13

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Epithelial Sodium Channel-Mediated Sodium Transport Is Not Dependent on the Membrane-Bound Serine Protease CAP2/Tmprss4. Keppner A, et al. PLoS One, 2015. PMID 26309024, Free PMC Article
  2. Transcriptome profiling and protease inhibition experiments identify proteases that activate H3N2 influenza A and influenza B viruses in murine airways. Harbig A, et al. J Biol Chem, 2020 Aug 14. PMID 32303635, Free PMC Article
  3. The Proteolytic Activation of (H3N2) Influenza A Virus Hemagglutinin Is Facilitated by Different Type II Transmembrane Serine Proteases. Kühn N, et al. J Virol, 2016 May. PMID 26889029, Free PMC Article
  4. TMPRSS4 is a type II transmembrane serine protease involved in cancer and viral infections. Ohler A, et al. Biol Chem, 2012 Sep. PMID 22944691
  5. TMPRSS4-dependent activation of the epithelial sodium channel requires cleavage of the γ-subunit distal to the furin cleavage site. Passero CJ, et al. Am J Physiol Renal Physiol, 2012 Jan 1. PMID 21993886, Free PMC Article

See all (26) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Transmembrane Protease TMPRSS4 Promotes the Formation and Development of Mismatch Repair Deficient Colon Cancer Liver Metastasis.
    Title: Transmembrane Protease TMPRSS4 Promotes the Formation and Development of Mismatch Repair Deficient Colon Cancer Liver Metastasis.
  2. The lung fibrotic response evaluated at 28 days after bleomycin injury was markedly attenuated in the haplodeficient and deficient TMPRSS4 mice.
    Title: Transmembrane protease, serine 4 (TMPRSS4) is upregulated in IPF lungs and increases the fibrotic response in bleomycin-induced lung injury.
  3. Epithelial Sodium Channel-Mediated Sodium Transport Is Not Dependent on the Membrane-Bound Serine Protease CAP2/Tmprss4
    Title: Epithelial Sodium Channel-Mediated Sodium Transport Is Not Dependent on the Membrane-Bound Serine Protease CAP2/Tmprss4.
  4. Progression and metastatic potential of several cancers is concordant with an increased expression of TMPRSS4.
    Title: TMPRSS4 is a type II transmembrane serine protease involved in cancer and viral infections.
  5. TMPRSS4 primarily activates ENaC by cleaving basic residues within the tract gammaK173-K186 distal to the furin cleavage site, thereby releasing a previously defined key inhibitory tract encompassing gammaR158-F168 from the gamma-subunit.
    Title: TMPRSS4-dependent activation of the epithelial sodium channel requires cleavage of the γ-subunit distal to the furin cleavage site.
  6. mutations in conserved residues of mCAP2 located in two protein-protein interacting domains significantly modulated ENaC activation
    Title: Activation of epithelial sodium channels by mouse channel activating proteases (mCAP) expressed in Xenopus oocytes requires catalytic activity of mCAP3 and mCAP2 but not mCAP1.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Targeted (3)  1 citation

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC29209

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables serine-type endopeptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables serine-type peptidase activity ISO
Inferred from Sequence Orthology
more info
  
enables serine-type peptidase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within negative regulation of growth rate ISO
Inferred from Sequence Orthology
more info
 PubMed 
involved_in positive regulation of viral entry into host cell ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of viral entry into host cell ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in protein processing ISO
Inferred from Sequence Orthology
more info
  
involved_in protein processing ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in proteolysis ISO
Inferred from Sequence Orthology
more info
  
involved_in proteolysis ISS
Inferred from Sequence or Structural Similarity
more info
  
acts_upstream_of_or_within regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 PubMed 
acts_upstream_of_or_within response to wounding IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
  
located_in extracellular space ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in secretory granule IDA
Inferred from Direct Assay
more info
 PubMed 
located_in secretory granule ISO
Inferred from Sequence Orthology
more info
 PubMed 

General protein information

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Preferred Names
transmembrane protease serine 4
Names
channel-activating protease 2
channel-activating protease 4
membrane-type serine protease 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001364528.1 → NP_001351457.1  transmembrane protease serine 4 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AK078890, EH103381
    Conserved Domains (2) summary
    smart00020
    Location:62 → 287
    Tryp_SPc; Trypsin-like serine protease
    cl02509
    Location:1 → 55
    SRCR_2; Scavenger receptor cysteine-rich domain

  2. NM_145403.3 → NP_663378.1  transmembrane protease serine 4 isoform 1

    See identical proteins and their annotated locations for NP_663378.1

    Status: VALIDATED

    Source sequence(s)
    AC122305, AC166051
    Consensus CDS
    CCDS40607.1
    UniProtKB/Swiss-Prot
    Q8VCA5
    Related
    ENSMUSP00000034599.9, ENSMUST00000034599.15
    Conserved Domains (4) summary
    smart00020
    Location:202 → 427
    Tryp_SPc; Trypsin-like serine protease
    cd00112
    Location:56 → 90
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
    cd00190
    Location:203 → 430
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
    cl02509
    Location:106 → 195
    SRCR_2; Scavenger receptor cysteine-rich domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    45084024..45115417 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017313272.1 → XP_017168761.1  transmembrane protease serine 4 isoform X1

    Conserved Domains (2) summary
    smart00020
    Location:62 → 287
    Tryp_SPc; Trypsin-like serine protease
    cl02509
    Location:1 → 55
    SRCR_2; Scavenger receptor cysteine-rich domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8VCA5.1 GenPept UniProtKB/Swiss-Prot:Q8VCA5

Gene LinkOut

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