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Bms1 BMS1, ribosome biogenesis factor [ Mus musculus (house mouse) ]

Gene ID: 213895, updated on 27-Nov-2024

Summary

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Official Symbol
Bms1provided by MGI
Official Full Name
BMS1, ribosome biogenesis factorprovided by MGI
Primary source
MGI:MGI:2446132
See related
Ensembl:ENSMUSG00000030138 AllianceGenome:MGI:2446132
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Bms1l; mKIAA0187
Summary
Predicted to enable GTP binding activity; GTPase activity; and U3 snoRNA binding activity. Predicted to be involved in endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) and maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA). Predicted to be located in chromosome; nucleolus; and nucleoplasm. Predicted to be part of small-subunit processome. Human ortholog(s) of this gene implicated in nonsyndromic aplasia cutis congenita. Orthologous to human BMS1 (BMS1 ribosome biogenesis factor). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Broad expression in CNS E11.5 (RPKM 14.2), liver E14 (RPKM 7.5) and 24 other tissues See more
Orthologs
human all
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Genomic context

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See Bms1 in Genome Data Viewer
Location:
6 F1; 6 55.86 cM
Exon count:
23
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (118360342..118396772, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (118383381..118419802, complement)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 30557 Neighboring gene predicted gene, 30498 Neighboring gene STARR-seq mESC enhancer starr_17136 Neighboring gene zinc finger protein 248 Neighboring gene zinc finger protein 9

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Cyclin B1/Cdk1 binds and phosphorylates Filamin A and regulates its ability to cross-link actin. Cukier IH, et al. FEBS Lett, 2007 Apr 17. PMID 17408621
  2. Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. Okazaki N, et al. DNA Res, 2003 Aug 31. PMID 14621295
  3. High-throughput discovery of novel developmental phenotypes. Dickinson ME, et al. Nature, 2016 Sep 22. PMID 27626380, Free PMC Article
  4. A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome. Hansen J, et al. Proc Natl Acad Sci U S A, 2003 Aug 19. PMID 12904583, Free PMC Article
  5. Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Ko MS, et al. Development, 2000 Apr. PMID 10725249

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Targeted (2) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • KIAA0187

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables GTP binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables U3 snoRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in ribosomal small subunit biogenesis ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in chromosome ISO
Inferred from Sequence Orthology
more info
  
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
part_of small-subunit processome ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
ribosome biogenesis protein BMS1 homolog
Names
BMS1 homolog, ribosome assembly protein
BMS1-like, ribosome assembly protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_194339.2 → NP_919320.1  ribosome biogenesis protein BMS1 homolog

    See identical proteins and their annotated locations for NP_919320.1

    Status: VALIDATED

    Source sequence(s)
    AC140466
    Consensus CDS
    CCDS20471.1
    UniProtKB/TrEMBL
    Q6PGF5, Q6ZQH0
    Related
    ENSMUSP00000032237.7, ENSMUST00000032237.8
    Conserved Domains (4) summary
    smart00785
    Location:231 → 317
    AARP2CN; AARP2CN (NUC121) domain
    cd01882
    Location:44 → 273
    BMS1; Bms1, an essential GTPase, promotes assembly of preribosomal RNA processing complexes
    COG5192
    Location:17 → 1275
    BMS1; GTP-binding protein required for 40S ribosome biogenesis [Translation, ribosomal structure and biogenesis]
    pfam04950
    Location:821 → 1108
    RIBIOP_C; 40S ribosome biogenesis protein Tsr1 and BMS1 C-terminal

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    118360342..118396772 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017321497.3 → XP_017176986.1  ribosome biogenesis protein BMS1 homolog isoform X1

    UniProtKB/TrEMBL
    Q6ZQH0
    Conserved Domains (1) summary
    COG5192
    Location:17 → 1301
    BMS1; GTP-binding protein required for 40S ribosome biogenesis [Translation, ribosomal structure and biogenesis]

RNA

  1. XR_377435.5 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version

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