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Dync2li1 dynein cytoplasmic 2 light intermediate chain 1 [ Mus musculus (house mouse) ]

Gene ID: 213575, updated on 4-Jan-2025

Summary

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Official Symbol
Dync2li1provided by MGI
Official Full Name
dynein cytoplasmic 2 light intermediate chain 1provided by MGI
Primary source
MGI:MGI:1913996
See related
Ensembl:ENSMUSG00000024253 AllianceGenome:MGI:1913996
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
LIC3; D2lic; CGI-60; mD2LIC; 4933404O11Rik
Summary
Predicted to enable dynein heavy chain binding activity. Acts upstream of or within cilium assembly and determination of left/right symmetry. Located in apical part of cell; axoneme; and motile cilium. Is expressed in several structures, including gut; heart; lung; metanephros; and node. Human ortholog(s) of this gene implicated in asphyxiating thoracic dystrophy. Orthologous to human DYNC2LI1 (dynein cytoplasmic 2 light intermediate chain 1). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Broad expression in CNS E11.5 (RPKM 9.3), CNS E18 (RPKM 7.9) and 19 other tissues See more
Orthologs
human all
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Genomic context

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See Dync2li1 in Genome Data Viewer
Location:
17 E4; 17 55.02 cM
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (84933903..84962996)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (84626475..84655568)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene pleckstrin homology domain containing, family H (with MyTH4 domain) member 2 Neighboring gene RIKEN cDNA 4930500A05 gene Neighboring gene predicted gene, 26066 Neighboring gene ATP binding cassette subfamily G member 5 Neighboring gene ATP binding cassette subfamily G member 8 Neighboring gene STARR-seq mESC enhancer starr_43448 Neighboring gene leucine-rich PPR-motif containing Neighboring gene STARR-seq mESC enhancer starr_43449 Neighboring gene STARR-positive B cell enhancer ABC_E3219

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. A novel dynein light intermediate chain colocalizes with the retrograde motor for intraflagellar transport at sites of axoneme assembly in chlamydomonas and Mammalian cells. Perrone CA, et al. Mol Biol Cell, 2003 May. PMID 12802074, Free PMC Article
  2. The transcription factor RFX3 directs nodal cilium development and left-right asymmetry specification. Bonnafe E, et al. Mol Cell Biol, 2004 May. PMID 15121860, Free PMC Article
  3. Targeted deletion of the novel cytoplasmic dynein mD2LIC disrupts the embryonic organiser, formation of the body axes and specification of ventral cell fates. Rana AA, et al. Development, 2004 Oct. PMID 15371312
  4. Quantitative Trait Locus Mapping of Macrophage Cholesterol Metabolism and CRISPR/Cas9 Editing Implicate an ACAT1 Truncation as a Causal Modifier Variant. Hai Q, et al. Arterioscler Thromb Vasc Biol, 2018 Jan. PMID 29097366, Free PMC Article
  5. Glomerulocystic kidney disease in mice with a targeted inactivation of Wwtr1. Hossain Z, et al. Proc Natl Acad Sci U S A, 2007 Jan 30. PMID 17251353, Free PMC Article

See all (23) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. required to maintain or establish ventral cell fates and for correct signalling by the organiser and midline
    Title: Targeted deletion of the novel cytoplasmic dynein mD2LIC disrupts the embryonic organiser, formation of the body axes and specification of ventral cell fates.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Targeted (1)  1 citation

Pathways from PubChem

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General gene information

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Markers

Homology

Clone Names

  • MGC7211, MGC40646

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables dynein heavy chain binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables dynein heavy chain binding ISO
Inferred from Sequence Orthology
more info
  
enables dynein heavy chain binding ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within cilium assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within determination of left/right symmetry IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in intraciliary retrograde transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in intraciliary retrograde transport IEA
Inferred from Electronic Annotation
more info
  
involved_in intraciliary transport involved in cilium assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in intraciliary transport involved in cilium assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in intraciliary transport involved in cilium assembly ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of cilium assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of cilium assembly ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in apical part of cell IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in axoneme IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in axoneme IDA
Inferred from Direct Assay
more info
 PubMed 
located_in centrosome ISO
Inferred from Sequence Orthology
more info
  
located_in centrosome ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in ciliary basal body IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in ciliary basal body ISO
Inferred from Sequence Orthology
more info
  
located_in ciliary basal body ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in ciliary transition zone ISO
Inferred from Sequence Orthology
more info
  
located_in ciliary transition zone ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
  
part_of cytoplasmic dynein complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of cytoplasmic dynein complex ISO
Inferred from Sequence Orthology
more info
  
part_of cytoplasmic dynein complex ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in microtubule IEA
Inferred from Electronic Annotation
more info
  
located_in motile cilium IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
cytoplasmic dynein 2 light intermediate chain 1
Names
dynein 2 light intermediate chain

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_172256.2 → NP_758460.1  cytoplasmic dynein 2 light intermediate chain 1

    See identical proteins and their annotated locations for NP_758460.1

    Status: VALIDATED

    Source sequence(s)
    AC132353
    Consensus CDS
    CCDS29000.1
    UniProtKB/Swiss-Prot
    Q3TVA2, Q8K0T2
    Related
    ENSMUSP00000025101.9, ENSMUST00000025101.10
    Conserved Domains (1) summary
    cl21455
    Location:37 → 241
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    84933903..84962996
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8K0T2.1 GenPept UniProtKB/Swiss-Prot:Q8K0T2

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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