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Txndc2 thioredoxin domain containing 2 (spermatozoa) [ Mus musculus (house mouse) ]

Gene ID: 213272, updated on 27-Nov-2024

Summary

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Official Symbol
Txndc2provided by MGI
Official Full Name
thioredoxin domain containing 2 (spermatozoa)provided by MGI
Primary source
MGI:MGI:2389312
See related
Ensembl:ENSMUSG00000050612 AllianceGenome:MGI:2389312
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Trx4; Sptrx1; Sptrx-1
Summary
Enables protein disulfide isomerase activity. Acts upstream of or within cellular response to reactive oxygen species and flagellated sperm motility. Located in sperm flagellum. Orthologous to human TXNDC2 (thioredoxin domain containing 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Restricted expression toward testis adult (RPKM 67.4) See more
Orthologs
human all
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Genomic context

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See Txndc2 in Genome Data Viewer
Location:
17 E1.1; 17 34.99 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (65944498..65955871, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (65637505..65648874, complement)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene protein (peptidyl-prolyl cis/trans isomerase) NIMA-interacting, 4 (parvulin) pseudogene Neighboring gene vesicle-associated membrane protein, associated protein A Neighboring gene predicted gene, 35477 Neighboring gene STARR-seq mESC enhancer starr_43016 Neighboring gene RAB31, member RAS oncogene family Neighboring gene STARR-seq mESC enhancer starr_43017 Neighboring gene STARR-seq mESC enhancer starr_43022 Neighboring gene STARR-seq mESC enhancer starr_43025 Neighboring gene protein phosphatase 4, regulatory subunit 1 Neighboring gene STARR-seq mESC enhancer starr_43027

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Developmental expression of spermatid-specific thioredoxin-1 protein: transient association to the longitudinal columns of the fibrous sheath during sperm tail formation. Yu Y, et al. Biol Reprod, 2002 Nov. PMID 12390887
  2. Cloning, expression and characterization of mouse spermatid specific thioredoxin-1 gene and protein. Jiménez A, et al. Mol Hum Reprod, 2002 Aug. PMID 12149401
  3. Absolute mRNA levels and transcriptional regulation of the mouse testis-specific thioredoxins. Jiménez A, et al. Biochem Biophys Res Commun, 2005 Apr 29. PMID 15781233
  4. Functional deletion of Txndc2 and Txndc3 increases the susceptibility of spermatozoa to age-related oxidative stress. Smith TB, et al. Free Radic Biol Med, 2013 Dec. PMID 23707457
  5. Expression of Arnt and Arnt2 mRNA in developing murine tissues. Aitola MH, et al. J Histochem Cytochem, 2003 Jan. PMID 12502753

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Txndc2 and Txndc3 are critically important in protecting spermatozoa against the increases in oxidative stress associated with paternal age.
    Title: Functional deletion of Txndc2 and Txndc3 increases the susceptibility of spermatozoa to age-related oxidative stress.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (5) 
  • Targeted (2)  1 citation

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein disulfide isomerase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables thioredoxin-disulfide reductase (NADPH) activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in cell differentiation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within cellular response to reactive oxygen species IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within flagellated sperm motility IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in spermatogenesis IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in outer dense fiber ISO
Inferred from Sequence Orthology
more info
  
located_in sperm flagellum IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
thioredoxin domain-containing protein 2
Names
spermatid-specific thioredoxin 1
thioredoxin-4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001146002.2 → NP_001139474.1  thioredoxin domain-containing protein 2 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC166058
    Consensus CDS
    CCDS50165.1
    UniProtKB/Swiss-Prot
    Q6P902, Q8CJD1
    UniProtKB/TrEMBL
    H7BX21
    Related
    ENSMUSP00000054909.6, ENSMUST00000050236.7
    Conserved Domains (2) summary
    PTZ00449
    Location:126 → 395
    PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
    cd02947
    Location:454 → 546
    TRX_family; TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox ...

  2. NM_001404092.1 → NP_001391021.1  thioredoxin domain-containing protein 2 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC166058
    UniProtKB/TrEMBL
    A0A3B2W416

  3. NM_001404098.1 → NP_001391027.1  thioredoxin domain-containing protein 2 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC166058
    UniProtKB/TrEMBL
    A0A3B2W416

  4. NM_153519.3 → NP_705739.2  thioredoxin domain-containing protein 2 isoform 2

    See identical proteins and their annotated locations for NP_705739.2

    Status: VALIDATED

    Source sequence(s)
    AC166058
    Consensus CDS
    CCDS89136.1
    UniProtKB/Swiss-Prot
    Q6P902, Q8CJD1
    UniProtKB/TrEMBL
    A0A3B2W416
    Related
    ENSMUSP00000156697.2, ENSMUST00000233702.2
    Conserved Domains (2) summary
    PTZ00449
    Location:119 → 388
    PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
    cd02947
    Location:447 → 539
    TRX_family; TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    65944498..65955871 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011246354.4 → XP_011244656.1  thioredoxin domain-containing protein 2 isoform X1

    See identical proteins and their annotated locations for XP_011244656.1

    UniProtKB/Swiss-Prot
    Q6P902, Q8CJD1
    UniProtKB/TrEMBL
    A0A3B2W416
    Conserved Domains (2) summary
    PTZ00449
    Location:119 → 388
    PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
    cd02947
    Location:447 → 539
    TRX_family; TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox ...
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6P902.1 GenPept UniProtKB/Swiss-Prot:Q6P902

Gene LinkOut

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