Tmc7 transmembrane channel-like gene family 7 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Tmc7provided by MGI
Official Full Name: transmembrane channel-like gene family 7provided by MGI
Primary source: MGI:MGI:2443317
See related: Ensembl:ENSMUSG00000042246 AllianceGenome:MGI:2443317
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: C230064B05; 1700030H01Rik; C630024K23Rik
Summary: Enables ion channel inhibitor activity. Involved in sensory perception of mechanical stimulus. Predicted to be located in plasma membrane. Orthologous to human TMC7 (transmembrane channel like 7). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in testis adult (RPKM 39.3), cerebellum adult (RPKM 4.2) and 7 other tissues See more
Orthologs: human all
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Genomic context

Location:: 7 F1; 7 63.44 cM

Exon count:: 17

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	7	NC_000073.7 (118135064..118184052, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	7	NC_000073.6 (118535841..118584829, complement)

Chromosome 7 - NC_000073.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

TMC7 deficiency causes acrosome biogenesis defects and male infertility in mice.
Title: TMC7 deficiency causes acrosome biogenesis defects and male infertility in mice.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ion channel inhibitor activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables mechanosensitive monoatomic ion channel activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in sensory perception of mechanical stimulus	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in cellular_component	ND No biological Data available more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: transmembrane channel-like protein 7

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_172476.5 → NP_766064.2 transmembrane channel-like protein 7

See identical proteins and their annotated locations for NP_766064.2

Status: VALIDATED

Source sequence(s)

AC122912, AC124444

Consensus CDS

CCDS21772.1

UniProtKB/Swiss-Prot

Q7TN59, Q7TQ66, Q8C428, Q8C4C3

Related

ENSMUSP00000046927.5, ENSMUST00000044195.6

Conserved Domains (1) summary

pfam07810
Location:489 → 590

TMC; TMC domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000073.7 Reference GRCm39 C57BL/6J

Range

118135064..118184052 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006507550.5 → XP_006507613.1 transmembrane channel-like protein 7 isoform X1

Conserved Domains (1) summary

pfam07810
Location:376 → 487

TMC; TMC domain
XM_036152862.1 → XP_036008755.1 transmembrane channel-like protein 7 isoform X1

Conserved Domains (1) summary

pfam07810
Location:376 → 487

TMC; TMC domain