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Minar1 membrane integral NOTCH2 associated receptor 1 [ Mus musculus (house mouse) ]

Gene ID: 209743, updated on 27-Nov-2024

Summary

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Official Symbol
Minar1provided by MGI
Official Full Name
membrane integral NOTCH2 associated receptor 1provided by MGI
Primary source
MGI:MGI:2667167
See related
Ensembl:ENSMUSG00000039313 AllianceGenome:MGI:2667167
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
DD1; Kiaa1024
Summary
Predicted to be involved in several processes, including negative regulation of TOR signaling; negative regulation of angiogenesis; and negative regulation of protein ubiquitination. Predicted to be active in plasma membrane. Orthologous to human MINAR1 (membrane integral NOTCH2 associated receptor 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Low expression observed in reference dataset See more
Orthologs
human all
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Genomic context

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See Minar1 in Genome Data Viewer
Location:
9 E3.1; 9 47.24 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (89469261..89505940, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (89587208..89623887, complement)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 57551 Neighboring gene STARR-seq mESC enhancer starr_24877 Neighboring gene predicted gene, 47403 Neighboring gene STARR-positive B cell enhancer ABC_E6786 Neighboring gene transmembrane p24 trafficking protein 3 Neighboring gene ankyrin repeat domain 34C

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Brn3a and Nurr1 mediate a gene regulatory pathway for habenula development. Quina LA, et al. J Neurosci, 2009 Nov 11. PMID 19906978, Free PMC Article
  2. Impaired OTUD7A-dependent Ankyrin regulation mediates neuronal dysfunction in mouse and human models of the 15q13.3 microdeletion syndrome. Unda BK, et al. Mol Psychiatry, 2023 Apr. PMID 36604605, Free PMC Article
  3. Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. Okazaki N, et al. DNA Res, 2004 Jun 30. PMID 15368895
  4. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article
  5. Genetic determinants of micronucleus formation in vivo. Adams DJ, et al. Nature, 2024 Mar. PMID 38355793, Free PMC Article

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in angiogenesis IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of TOR signaling IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of TOR signaling ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of TOR signaling ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in negative regulation of angiogenesis ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of angiogenesis ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in negative regulation of cell growth ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of cell growth ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in negative regulation of cell population proliferation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of cell population proliferation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in negative regulation of neuron projection development ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of neuron projection development ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in negative regulation of protein ubiquitination ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of protein ubiquitination ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
major intrinsically disordered Notch2-binding receptor 1
Names
ubiquitination and mTOR signaling protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_153509.2 → NP_705729.1  major intrinsically disordered Notch2-binding receptor 1

    See identical proteins and their annotated locations for NP_705729.1

    Status: PROVISIONAL

    Source sequence(s)
    AC121793
    Consensus CDS
    CCDS23395.1
    UniProtKB/Swiss-Prot
    Q14CG5, Q69ZS9, Q8K3V7
    UniProtKB/TrEMBL
    A0A087WS88
    Related
    ENSMUSP00000046111.7, ENSMUST00000044491.13
    Conserved Domains (1) summary
    pfam06789
    Location:760 → 912
    UPF0258; Uncharacterized protein family (UPF0258)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    89469261..89505940 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036154777.1 → XP_036010670.1  major intrinsically disordered Notch2-binding receptor 1 isoform X1

    UniProtKB/Swiss-Prot
    Q14CG5, Q69ZS9, Q8K3V7
    UniProtKB/TrEMBL
    A0A087WS88
    Conserved Domains (1) summary
    pfam06789
    Location:760 → 912
    UPF0258; Uncharacterized protein family (UPF0258)

  2. XM_036154776.1 → XP_036010669.1  major intrinsically disordered Notch2-binding receptor 1 isoform X1

    UniProtKB/Swiss-Prot
    Q14CG5, Q69ZS9, Q8K3V7
    UniProtKB/TrEMBL
    A0A087WS88
    Conserved Domains (1) summary
    pfam06789
    Location:760 → 912
    UPF0258; Uncharacterized protein family (UPF0258)

  3. XM_006510957.5 → XP_006511020.1  major intrinsically disordered Notch2-binding receptor 1 isoform X1

    See identical proteins and their annotated locations for XP_006511020.1

    UniProtKB/Swiss-Prot
    Q14CG5, Q69ZS9, Q8K3V7
    UniProtKB/TrEMBL
    A0A087WS88
    Conserved Domains (1) summary
    pfam06789
    Location:760 → 912
    UPF0258; Uncharacterized protein family (UPF0258)

  4. XM_017313265.2 → XP_017168754.1  major intrinsically disordered Notch2-binding receptor 1 isoform X1

    UniProtKB/Swiss-Prot
    Q14CG5, Q69ZS9, Q8K3V7
    UniProtKB/TrEMBL
    A0A087WS88
    Conserved Domains (1) summary
    pfam06789
    Location:760 → 912
    UPF0258; Uncharacterized protein family (UPF0258)

RNA

  1. XR_379408.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8K3V7.1 GenPept UniProtKB/Swiss-Prot:Q8K3V7

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