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Btla B and T lymphocyte associated [ Mus musculus (house mouse) ]

Gene ID: 208154, updated on 27-Nov-2024

Summary

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Official Symbol
Btlaprovided by MGI
Official Full Name
B and T lymphocyte associatedprovided by MGI
Primary source
MGI:MGI:2658978
See related
Ensembl:ENSMUSG00000052013 AllianceGenome:MGI:2658978
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
A630002H24
Summary
Enables signaling receptor activity. Acts upstream of or within immune response-regulating cell surface receptor signaling pathway; negative regulation of B cell proliferation; and negative regulation of alpha-beta T cell proliferation. Located in external side of plasma membrane. Is expressed in adipose tissue; chondrocranium; femur; lung; and spleen. Orthologous to human BTLA (B and T lymphocyte associated). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in spleen adult (RPKM 9.3), mammary gland adult (RPKM 3.5) and 3 other tissues See more
Orthologs
human all
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Genomic context

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See Btla in Genome Data Viewer
Location:
16 B5; 16 29.52 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (45043121..45073258)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (45223705..45252895)

Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene autophagy related 3 Neighboring gene STARR-positive B cell enhancer ABC_E1925 Neighboring gene 40S ribosomal protein S24-like Neighboring gene STARR-seq mESC enhancer starr_40914 Neighboring gene STARR-positive B cell enhancer ABC_E8910 Neighboring gene STARR-positive B cell enhancer ABC_E11614 Neighboring gene STARR-seq mESC enhancer starr_40915 Neighboring gene STARR-seq mESC enhancer starr_40916 Neighboring gene STARR-seq mESC enhancer starr_40917 Neighboring gene predicted gene, 30636 Neighboring gene STARR-positive B cell enhancer ABC_E7454 Neighboring gene predicted gene, 30760

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Systemic minor histocompatibility antigen expression in blood endothelial cells prevents T cell-mediated vascular immunopathology. Caviezel-Firner S, et al. Eur J Immunol, 2013 Dec. PMID 23963995
  2. Cutting edge: A critical role of B and T lymphocyte attenuator in peripheral T cell tolerance induction. Liu X, et al. J Immunol, 2009 Apr 15. PMID 19342624, Free PMC Article
  3. Editorial: Therapeutic potential of targeting BTLA. Crawford A, et al. J Leukoc Biol, 2009 Jul. PMID 19567411
  4. Development of autoimmune hepatitis-like disease and production of autoantibodies to nuclear antigens in mice lacking B and T lymphocyte attenuator. Oya Y, et al. Arthritis Rheum, 2008 Aug. PMID 18668554, Free PMC Article
  5. Activation-induced accumulation of B and T lymphocyte attenuator at the immunological synapse in CD4+ T cells. Owada T, et al. J Leukoc Biol, 2010 Mar. PMID 19892849, Free PMC Article

See all (83) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. N-Glycan Branching Regulates BTLA Opposite to PD-1 to Limit T Cell Hyperactivity Induced by Branching Deficiency.
    Title: N-Glycan Branching Regulates BTLA Opposite to PD-1 to Limit T Cell Hyperactivity Induced by Branching Deficiency.
  2. The BTLA-HVEM axis restricts CAR T cell efficacy in cancer.
    Title: The BTLA-HVEM axis restricts CAR T cell efficacy in cancer.
  3. BTLA deficiency promotes HSC activation and protects against hepatic ischemia-reperfusion injury.
    Title: BTLA deficiency promotes HSC activation and protects against hepatic ischemia-reperfusion injury.
  4. BTLA contributes to acute-on-chronic liver failure infection and mortality through CD4[+] T-cell exhaustion.
    Title: BTLA contributes to acute-on-chronic liver failure infection and mortality through CD4(+) T-cell exhaustion.
  5. The HVEM-BTLA Immune Checkpoint Restrains Murine Chronic Cholestatic Liver Injury by Regulating the Gut Microbiota.
    Title: The HVEM-BTLA Immune Checkpoint Restrains Murine Chronic Cholestatic Liver Injury by Regulating the Gut Microbiota.
  6. Simultaneous transduction of dendritic cells with A20 and BTLA genes stimulates the development of stable and efficient tolerogenic dendritic cells and induces regulatory T cells.
    Title: Simultaneous transduction of dendritic cells with A20 and BTLA genes stimulates the development of stable and efficient tolerogenic dendritic cells and induces regulatory T cells.
  7. B and T lymphocyte attenuator regulates autophagy in mycobacterial infection via the AKT/mTOR signal pathway.
    Title: B and T lymphocyte attenuator regulates autophagy in mycobacterial infection via the AKT/mTOR signal pathway.
  8. these results suggest that BTLA functions as a cell-extrinsic suppressor of germinal center B cell lymphomagenesis
    Title: The HVEM-BTLA Axis Restrains T Cell Help to Germinal Center B Cells and Functions as a Cell-Extrinsic Suppressor in Lymphomagenesis.
  9. Soluble BTLA is produced as a result of alternative RNA splicing. This isoform of BTLA has biological significance through changes in cellular proliferation and can predict the diagnosis of sepsis.
    Title: Changes in the process of alternative RNA splicing results in soluble B and T lymphocyte attenuator with biological and clinical implications in critical illness.
  10. these data support a role of BTLA on type I NKT cells in limiting anti-tumor immunity.
    Title: Downregulation of BTLA on NKT Cells Promotes Tumor Immune Control in a Mouse Model of Mammary Carcinoma.
Submit: New GeneRIF Correction See all GeneRIFs (53)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (8) 
  • Targeted (5)  1 citation

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC124217, MGC124218

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables signaling receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables signaling receptor activity IGI
Inferred from Genetic Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in adaptive immune response IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within cell surface receptor signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in immune response-regulating cell surface receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within immune response-regulating cell surface receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within negative regulation of B cell proliferation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within negative regulation of T cell proliferation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within negative regulation of alpha-beta T cell proliferation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in external side of plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane TAS
Traceable Author Statement
more info
  

General protein information

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Preferred Names
B- and T-lymphocyte attenuator
Names
B- and T-lymphocyte-associated protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001037719.2 → NP_001032808.2  B- and T-lymphocyte attenuator isoform 1 precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer transcript and it encodes the longer protein (isoform 1).
    Source sequence(s)
    AK041334, BB123968, BC108964
    Consensus CDS
    CCDS28195.1
    UniProtKB/Swiss-Prot
    Q7TSA3
    UniProtKB/TrEMBL
    E9QNY6
    Related
    ENSMUSP00000067877.5, ENSMUST00000063654.6
    Conserved Domains (2) summary
    smart00410
    Location:50 → 142
    IG_like; Immunoglobulin like
    cl11960
    Location:97 → 143
    Ig; Immunoglobulin domain

  2. NM_177584.3 → NP_808252.1  B- and T-lymphocyte attenuator isoform 2 precursor

    See identical proteins and their annotated locations for NP_808252.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 3' coding region, compared to variant 1, resulting in a shorter protein (isoform 2).
    Source sequence(s)
    AK041334, BB123968
    Consensus CDS
    CCDS28196.1
    UniProtKB/Swiss-Prot
    Q7TSA3
    UniProtKB/TrEMBL
    A0A0R4J1A0
    Related
    ENSMUSP00000099866.4, ENSMUST00000102802.10
    Conserved Domains (2) summary
    smart00410
    Location:50 → 142
    IG_like; Immunoglobulin like
    cl11960
    Location:97 → 143
    Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000082.7 Reference GRCm39 C57BL/6J

    Range
    45043121..45073258
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036159833.1 → XP_036015726.1  B- and T-lymphocyte attenuator isoform X3

    Conserved Domains (2) summary
    cd00096
    Location:42 → 47
    Ig; Ig strand A [structural motif]
    cl11960
    Location:40 → 143
    Ig; Immunoglobulin domain

  2. XM_036159834.1 → XP_036015727.1  B- and T-lymphocyte attenuator isoform X3

    Conserved Domains (2) summary
    cd00096
    Location:42 → 47
    Ig; Ig strand A [structural motif]
    cl11960
    Location:40 → 143
    Ig; Immunoglobulin domain

  3. XM_006521907.5 → XP_006521970.1  B- and T-lymphocyte attenuator isoform X1

  4. XM_006521908.5 → XP_006521971.1  B- and T-lymphocyte attenuator isoform X2

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q7TSA3.2 GenPept UniProtKB/Swiss-Prot:Q7TSA3

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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