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Gtpbp10 GTP-binding protein 10 (putative) [ Mus musculus (house mouse) ]

Gene ID: 207704, updated on 27-Nov-2024

Summary

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Official Symbol
Gtpbp10provided by MGI
Official Full Name
GTP-binding protein 10 (putative)provided by MGI
Primary source
MGI:MGI:2385599
See related
Ensembl:ENSMUSG00000040464 AllianceGenome:MGI:2385599
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
4930545J22Rik
Summary
Predicted to enable GTP binding activity. Predicted to be involved in ribosome biogenesis. Located in mitochondrion. Is expressed in cardiovascular system; genitourinary system; gut; lung; and skin. Orthologous to human GTPBP10 (GTP binding protein 10). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Broad expression in CNS E11.5 (RPKM 6.4), CNS E14 (RPKM 4.3) and 21 other tissues See more
Orthologs
human all
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Genomic context

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See Gtpbp10 in Genome Data Viewer
Location:
5 A1; 5 3.02 cM
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (5587454..5609541, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (5537454..5559541, complement)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 30325 Neighboring gene claudin 12 Neighboring gene family with sequence similarity 237, member B Neighboring gene cilia and flagella associated protein 69

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article
  2. The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data. Koscielny G, et al. Nucleic Acids Res, 2014 Jan. PMID 24194600, Free PMC Article
  3. EUCOMM--the European conditional mouse mutagenesis program. Friedel RH, et al. Brief Funct Genomic Proteomic, 2007 Sep. PMID 17967808
  4. BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain. Pourhaghighi R, et al. Cell Syst, 2020 Apr 22. PMID 32325033, Free PMC Article
  5. Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray. Tanaka TS, et al. Proc Natl Acad Sci U S A, 2000 Aug 1. PMID 10922068, Free PMC Article

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Targeted (2) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC30495

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables GTP binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTP binding IEA
Inferred from Electronic Annotation
more info
  
enables GTPase activity IEA
Inferred from Electronic Annotation
more info
  
enables magnesium ion binding IEA
Inferred from Electronic Annotation
more info
  
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
involved_in ribosome biogenesis IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in mitochondrion HDA PubMed 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleolus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
GTP-binding protein 10

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001357031.1 → NP_001343960.1  GTP-binding protein 10 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate splice junction in the 3' coding sequence compared to variant 1, that causes a frameshift. The resulting isoform (2) has a shorter and distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AC026813, AC068663
    Conserved Domains (1) summary
    cl25666
    Location:15 → 296
    HflX; 50S ribosomal subunit-associated GTPase HflX [Translation, ribosomal structure and biogenesis]

  2. NM_001357032.1 → NP_001343961.1  GTP-binding protein 10 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks two consecutive alternate exons compared to variant 1. The resulting isoform (3) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    AC026813, AC068663
    UniProtKB/TrEMBL
    F8WHJ2
    Related
    ENSMUSP00000113648.3, ENSMUST00000119521.8
    Conserved Domains (2) summary
    cd01898
    Location:108 → 270
    Obg; Obg GTPase
    pfam01018
    Location:16 → 106
    GTP1_OBG; GTP1/OBG

  3. NM_153116.2 → NP_694756.1  GTP-binding protein 10 isoform 1.

    See identical proteins and their annotated locations for NP_694756.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AC026813, AC068663, AK160252
    Consensus CDS
    CCDS39006.1
    UniProtKB/Swiss-Prot
    Q8K013
    Related
    ENSMUSP00000111101.3, ENSMUST00000115441.9
    Conserved Domains (3) summary
    cd01898
    Location:149 → 343
    Obg; Obg GTPase
    TIGR02729
    Location:15 → 343
    Obg_CgtA; Obg family GTPase CgtA
    pfam01018
    Location:15 → 145
    GTP1_OBG; GTP1/OBG

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    5587454..5609541 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8K013.1 GenPept UniProtKB/Swiss-Prot:Q8K013

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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