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PAGE2 PAGE family member 2 [ Homo sapiens (human) ]

Gene ID: 203569, updated on 27-Nov-2024

Summary

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Official Symbol
PAGE2provided by HGNC
Official Full Name
PAGE family member 2provided by HGNC
Primary source
HGNC:HGNC:31804
See related
Ensembl:ENSG00000234068 MIM:300738; AllianceGenome:HGNC:31804
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CT16.4; GAGEC2; GAGEE2; PAGE-2
Expression
Restricted expression toward testis (RPKM 10.7) See more
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Genomic context

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See PAGE2 in Genome Data Viewer
Location:
Xp11.21
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) X NC_000023.11 (55089018..55092842)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) X NC_060947.1 (54382141..54385964)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (55115451..55119275)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene ALAS2 intronic erythroid enhancer Neighboring gene apurinic/apyrimidinic endodeoxyribonuclease 2 Neighboring gene ALAS2 intron 1 and 3 erythroid regulatory elements Neighboring gene 5'-aminolevulinate synthase 2 Neighboring gene PAGE family member 2B Neighboring gene HDGFL3 pseudogene 1 Neighboring gene CRISPRi-validated cis-regulatory element chrX.1184 Neighboring gene component of oligomeric golgi complex 1 pseudogene Neighboring gene H3K4me1 hESC enhancer GRCh37_chrX:55187406-55187906 Neighboring gene VCP nuclear cofactor family member 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Epigenetic mechanisms underlying the dynamic expression of cancer-testis genes, PAGE2, -2B and SPANX-B, during mesenchymal-to-epithelial transition. Yilmaz-Ozcan S, et al. PLoS One, 2014. PMID 25229454, Free PMC Article
  2. PAGE-1, an X chromosome-linked GAGE-like gene that is expressed in normal and neoplastic prostate, testis, and uterus. Brinkmann U, et al. Proc Natl Acad Sci U S A, 1998 Sep 1. PMID 9724777, Free PMC Article
  3. Genome-wide YFP fluorescence complementation screen identifies new regulators for telomere signaling in human cells. Lee OH, et al. Mol Cell Proteomics, 2011 Feb. PMID 21044950, Free PMC Article
  4. The DNA sequence and comparative analysis of human chromosome 10. Deloukas P, et al. Nature, 2004 May 27. PMID 15164054
  5. A proteome-scale map of the human interactome network. Rolland T, et al. Cell, 2014 Nov 20. PMID 25416956, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Epigenetic mechanisms underlying the dynamic expression of cancer-testis genes, PAGE2, -2B and SPANX-B, during mesenchymal-to-epithelial transition
    Title: Epigenetic mechanisms underlying the dynamic expression of cancer-testis genes, PAGE2, -2B and SPANX-B, during mesenchymal-to-epithelial transition.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Clone Names

  • MGC62094

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 

General protein information

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Preferred Names
P antigen family member 2
Names
G antigen family C 2
G antigen, family E, 2
P antigen family, member 2 (prostate associated)
g antigen family E member 2
prostate-associated gene 2 protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_207339.4 → NP_997222.1  P antigen family member 2

    See identical proteins and their annotated locations for NP_997222.1

    Status: VALIDATED

    Source sequence(s)
    AA815378, AL590240, BC054022, BX113994
    Consensus CDS
    CCDS14367.1
    UniProtKB/Swiss-Prot
    Q5JRK7, Q5JRK8, Q7Z2X7
    UniProtKB/TrEMBL
    X6R922
    Related
    ENSP00000364107.4, ENST00000374968.9
    Conserved Domains (1) summary
    pfam05831
    Location:1 → 107
    GAGE; GAGE protein

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p14 Primary Assembly

    Range
    55089018..55092842
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017029353.2 → XP_016884842.1  P antigen family member 2 isoform X1

    UniProtKB/Swiss-Prot
    Q5JRK7, Q5JRK8, Q7Z2X7
    UniProtKB/TrEMBL
    X6R922
    Conserved Domains (1) summary
    pfam05831
    Location:1 → 107
    GAGE; GAGE protein

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060947.1 Alternate T2T-CHM13v2.0

    Range
    54382141..54385964
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q7Z2X7.1 GenPept UniProtKB/Swiss-Prot:Q7Z2X7

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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