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TMEM154 transmembrane protein 154 [ Homo sapiens (human) ]

Gene ID: 201799, updated on 27-Nov-2024

Summary

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Official Symbol
TMEM154provided by HGNC
Official Full Name
transmembrane protein 154provided by HGNC
Primary source
HGNC:HGNC:26489
See related
Ensembl:ENSG00000170006 AllianceGenome:HGNC:26489
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Predicted to be located in membrane. [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in skin (RPKM 20.4), esophagus (RPKM 13.6) and 11 other tissues See more
Orthologs
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Genomic context

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See TMEM154 in Genome Data Viewer
Location:
4q31.3
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 4 NC_000004.12 (152618628..152679997, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 4 NC_060928.1 (155941796..156003145, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (153539780..153601149, complement)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22034 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22035 Neighboring gene RPS3A pseudogene 18 Neighboring gene H3K27ac hESC enhancer GRCh37_chr4:153528082-153528582 Neighboring gene ribosomal protein S14 pseudogene 6 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22036 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22037 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22038 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22039 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22040 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15752 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22041 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:153600783-153601612 Neighboring gene uncharacterized LOC105377495 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22043 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22044 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr4:153621867-153622378 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:153628279-153628780 Neighboring gene NANOG hESC enhancer GRCh37_chr4:153649784-153650339 Neighboring gene H3K27ac hESC enhancer GRCh37_chr4:153661870-153662370 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:153669773-153670273 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22045 Neighboring gene tigger transposable element derived 4

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. The type 2 diabetes risk allele of TMEM154-rs6813195 associates with decreased beta cell function in a study of 6,486 Danes. Harder MN, et al. PLoS One, 2015. PMID 25799151, Free PMC Article
  2. Reduced lentivirus susceptibility in sheep with TMEM154 mutations. Heaton MP, et al. PLoS Genet, 2012 Jan. PMID 22291605, Free PMC Article
  3. Genetic associations of TMEM154, PRC1 and ZFAND6 loci with type 2 diabetes in an endogamous business community of North India. Walia GK, et al. PLoS One, 2023. PMID 37738238, Free PMC Article
  4. Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility. DIAbetes Genetics Replication And Meta-analysis (DIAGRAM) Consortium, et al. Nat Genet, 2014 Mar. PMID 24509480, Free PMC Article
  5. A comprehensive SARS-CoV-2-human protein-protein interactome reveals COVID-19 pathobiology and potential host therapeutic targets. Zhou Y, et al. Nat Biotechnol, 2023 Jan. PMID 36217030, Free PMC Article

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Genetic associations of TMEM154, PRC1 and ZFAND6 loci with type 2 diabetes in an endogamous business community of North India.
    Title: Genetic associations of TMEM154, PRC1 and ZFAND6 loci with type 2 diabetes in an endogamous business community of North India.
  2. the diabetogenic impact of the C-allele of TMEM154-rs6813195 is mediated through reduced beta cell function.
    Title: The type 2 diabetes risk allele of TMEM154-rs6813195 associates with decreased beta cell function in a study of 6,486 Danes.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ32028

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
transmembrane protein 154

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_152680.3 → NP_689893.1  transmembrane protein 154 precursor

    See identical proteins and their annotated locations for NP_689893.1

    Status: VALIDATED

    Source sequence(s)
    AC023424, AC106882
    Consensus CDS
    CCDS3779.1
    UniProtKB/Swiss-Prot
    Q6P9G4, Q8WUT7, Q96MQ8
    UniProtKB/TrEMBL
    B4DKS6
    Related
    ENSP00000302144.3, ENST00000304385.8
    Conserved Domains (1) summary
    pfam15102
    Location:24 → 165
    TMEM154; TMEM154 protein family

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p14 Primary Assembly

    Range
    152618628..152679997 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011531716.4 → XP_011530018.1  transmembrane protein 154 isoform X1

    UniProtKB/TrEMBL
    A0A994J4V3
    Related
    ENSP00000516115.1, ENST00000705347.1
    Conserved Domains (1) summary
    pfam15102
    Location:24 → 124
    TMEM154; TMEM154 protein family

RNA

  1. XR_001741158.3 RNA Sequence

  2. XR_007096383.1 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060928.1 Alternate T2T-CHM13v2.0

    Range
    155941796..156003145 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054349162.1 → XP_054205137.1  transmembrane protein 154 isoform X1

RNA

  1. XR_008486946.1 RNA Sequence

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6P9G4.2 GenPept UniProtKB/Swiss-Prot:Q6P9G4

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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