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SclB Sarcolamban B [ Drosophila melanogaster (fruit fly) ]

Gene ID: 19834948, updated on 4-Jan-2025

Summary

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Official Symbol
SclBprovided by FlyBase
Official Full Name
Sarcolamban Bprovided by FlyBase
Primary source
FLYBASE:FBgn0266492
Locus tag
Dmel_CG45091
See related
AllianceGenome:FB:FBgn0266492
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
BcDNA:RE28911; BEST:LP06756; CG45091; CR31696; Dmel\CG45091; mel2; ORF-B; pcnr003:2L; pncr003; pncr003:2L; pncr003:2L ORFB; pncr:003:2L; scl; SCLB
Summary
Involved in regulation of cardiac muscle contraction. Is expressed in adult heart; embryonic/larval heart; larval muscle system; and larval somatic muscle cell. [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See SclB in Genome Data Viewer
Location:
36B2-36B2; 2-53 cM
Exon count:
7
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (16837972..16841884)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (16837972..16841884)

Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene Aspartyl-tRNA synthetase, mitochondrial Neighboring gene uncharacterized protein Neighboring gene Neprilysin-like 9 Neighboring gene Sarcolamban A Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Neprilysins regulate muscle contraction and heart function via cleavage of SERCA-inhibitory micropeptides. Schiemann R, et al. Nat Commun, 2022 Jul 29. PMID 35906206, Free PMC Article
  2. Neprilysin 4: an essential peptidase with multifaceted physiological relevance. Buhr A, et al. Biol Chem, 2023 Apr 25. PMID 36653344
  3. Functions of long non-coding RNAs in human disease and their conservation in Drosophila development. Rogoyski OM, et al. Biochem Soc Trans, 2017 Aug 15. PMID 28673935
  4. small ORFs: A new class of essential genes for development. Albuquerque JP, et al. Genet Mol Biol, 2015 Jul-Sep. PMID 26500431, Free PMC Article
  5. A segmentation gene in tribolium produces a polycistronic mRNA that codes for multiple conserved peptides. Savard J, et al. Cell, 2006 Aug 11. PMID 16901788

See all (28) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Gene Ontology Provided by FlyBase

Process Evidence Code Pubs
involved_in regulation of cardiac muscle contraction IMP
Inferred from Mutant Phenotype
more info
 PubMed 

General protein information

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Preferred Names
sarcolamban B
Names
CG45091-PA
CG45091-PB
CG45091-PC
CG45091-PD
SclB-PA
SclB-PB
SclB-PC
SclB-PD
sarcolamban

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033779.5 Reference assembly

    Range
    16837972..16841884
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001299063.1 → NP_001285992.1  sarcolamban B, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001285992.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    C0HJH3, X2JAM8
    Conserved Domains (1) summary
    cd20274
    Location:2 → 28
    Sarcolamban; Sarcolamban A and B bioactive peptides and similar proteins

  2. NM_001299062.1 → NP_001285991.1  sarcolamban B, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001285991.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    C0HJH3, X2JAM8
    Conserved Domains (1) summary
    cd20274
    Location:2 → 28
    Sarcolamban; Sarcolamban A and B bioactive peptides and similar proteins

  3. NM_001299064.1 → NP_001285993.1  sarcolamban B, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001285993.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    C0HJH3, X2JAM8
    Conserved Domains (1) summary
    cd20274
    Location:2 → 28
    Sarcolamban; Sarcolamban A and B bioactive peptides and similar proteins

  4. NM_001299061.1 → NP_001285990.1  sarcolamban B, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001285990.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    C0HJH3, X2JAM8
    Conserved Domains (1) summary
    cd20274
    Location:2 → 28
    Sarcolamban; Sarcolamban A and B bioactive peptides and similar proteins
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
C0HJH3.1 C0HJH3

Gene LinkOut

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