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CG44249 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

Gene ID: 19834761, updated on 4-Jan-2025

Summary

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Official Symbol
CG44249provided by FlyBase
Official Full Name
uncharacterized proteinprovided by FlyBase
Primary source
FLYBASE:FBgn0265184
Locus tag
Dmel_CG44249
See related
AllianceGenome:FB:FBgn0265184
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
65K; cg11478; CG11478; CG30327; CG42257; Dm65K; Dmel\CG44249
Summary
Predicted to enable U12 snRNA binding activity and pre-mRNA intronic binding activity. Involved in alternative mRNA splicing, via spliceosome. Part of U11/U12 snRNP; U12 snRNP; and U12-type spliceosomal complex. Human ortholog(s) of this gene implicated in panhypopituitarism. Orthologous to human RNPC3 (RNA binding region (RNP1, RRM) containing 3). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
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Genomic context

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See CG44249 in Genome Data Viewer
Location:
58B1-58B2; 2-98 cM
Exon count:
1
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (22066883..22068372)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (17954388..17955877)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene Gustatory receptor-like 58a Neighboring gene uncharacterized protein Neighboring gene Snipper Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Minor Spliceosomal 65K/RNPC3 Interacts with ANKRD11 and Mediates HDAC3-Regulated Histone Deacetylation and Transcription. Li CH, et al. Adv Sci (Weinh), 2024 Aug. PMID 38837887, Free PMC Article
  2. Identification of an evolutionarily divergent U11 small nuclear ribonucleoprotein particle in Drosophila. Schneider C, et al. Proc Natl Acad Sci U S A, 2004 Jun 29. PMID 15210936, Free PMC Article
  3. Defective minor spliceosomes induce SMA-associated phenotypes through sensitive intron-containing neural genes in Drosophila. Li L, et al. Nat Commun, 2020 Nov 5. PMID 33154379, Free PMC Article
  4. The drosophila melanogaster genome: translation factors and RNA binding proteins. Lasko P. J Cell Biol, 2000 Jul 24. PMID 10908586, Free PMC Article
  5. Transcription elongation rate has a tissue-specific impact on alternative cleavage and polyadenylation in Drosophila melanogaster. Liu X, et al. RNA, 2017 Dec. PMID 28851752, Free PMC Article

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables U12 snRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables nucleic acid binding ISM
Inferred from Sequence Model
more info
  
enables pre-mRNA intronic binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in alternative mRNA splicing, via spliceosome IC
Inferred by Curator
more info
 PubMed 
involved_in alternative mRNA splicing, via spliceosome IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in mRNA splicing, via spliceosome IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of U11/U12 snRNP IDA
Inferred from Direct Assay
more info
 PubMed 
part_of U12 snRNP IDA
Inferred from Direct Assay
more info
 PubMed 
part_of U12-type spliceosomal complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of U12-type spliceosomal complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of U12-type spliceosomal complex ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 

General protein information

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Preferred Names
uncharacterized protein
Names
CG44249-PA

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    22066883..22068372
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001299774.1 → NP_001286703.1  uncharacterized protein Dmel_CG44249 [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001286703.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4LGA2, Q29QR9
    Conserved Domains (2) summary
    COG0724
    Location:317 → 401
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
    cd12239
    Location:325 → 404
    RRM2_RBM40_like; RNA recognition motif 2 in RNA-binding protein 40 (RBM40) and similar proteins
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A0A0B4LGA2 A0A0B4LGA2

Gene LinkOut

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Research Materials
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