Rbmx RNA binding motif protein, X chromosome [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Rbmxprovided by MGI
Official Full Name: RNA binding motif protein, X chromosomeprovided by MGI
Primary source: MGI:MGI:1343044
See related: Ensembl:ENSMUSG00000031134 AllianceGenome:MGI:1343044
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: hnRNP G
Summary: Predicted to enable several functions, including chromatin binding activity; identical protein binding activity; and nucleic acid binding activity. Predicted to be involved in several processes, including RNA metabolic process; cellular response to interleukin-1; and regulation of RNA metabolic process. Predicted to be located in euchromatin; extracellular exosome; and nucleus. Predicted to be part of catalytic step 2 spliceosome and supraspliceosomal complex. Predicted to be active in glutamatergic synapse and postsynaptic density. Is expressed in several structures, including central nervous system; female reproductive system; gut; sensory organ; and thymus. Human ortholog(s) of this gene implicated in X-linked mental retardation Gustavson type and syndromic X-linked intellectual disability Shashi type. Orthologous to human RBMX (RNA binding motif protein X-linked). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Broad expression in CNS E14 (RPKM 55.1), CNS E11.5 (RPKM 51.1) and 20 other tissues See more
Orthologs: human all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: X A6; X 31.64 cM

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	X	NC_000086.8 (56428708..56438405, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	X	NC_000086.7 (57383348..57393046, complement)

Chromosome X - NC_000086.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help

See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

These results indicate a major role for SAFB1 in the activation of Srebp-1c through its interaction with RBMX.
Title: SAFB1, an RBMX-binding protein, is a newly identified regulator of hepatic SREBP-1c gene.
RBMX may control SREBP-1c expression in mouse liver in response to high-fructose diet.
Title: RBMX is a novel hepatic transcriptional regulator of SREBP-1c gene response to high-fructose diet.

Submit: New GeneRIF Correction

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3)
Targeted (3)

Interactions

Go to the top of the page Help

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

Go to the top of the page Help

Markers

Rbmx (e-PCR), detects polymorphism
- UniSTS:479240

G42696 (e-PCR)
- UniSTS:140883

MARC_10315-10316:998935409:1 (e-PCR)
- UniSTS:267109

NoName (e-PCR)
- UniSTS:238029

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables RNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA binding	ISO Inferred from Sequence Orthology more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
enables chromatin binding	IEA Inferred from Electronic Annotation more info
enables chromatin binding	ISO Inferred from Sequence Orthology more info
enables identical protein binding	IEA Inferred from Electronic Annotation more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables mRNA binding	IEA Inferred from Electronic Annotation more info
enables mRNA binding	ISO Inferred from Sequence Orthology more info
enables protein domain specific binding	IEA Inferred from Electronic Annotation more info
enables protein domain specific binding	ISO Inferred from Sequence Orthology more info
enables single-stranded RNA binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in RNA splicing	IEA Inferred from Electronic Annotation more info
involved_in cellular response to interleukin-1	IEA Inferred from Electronic Annotation more info
involved_in cellular response to interleukin-1	ISO Inferred from Sequence Orthology more info
involved_in mRNA processing	IEA Inferred from Electronic Annotation more info
involved_in mRNA splice site recognition	ISO Inferred from Sequence Orthology more info
involved_in membrane protein ectodomain proteolysis	IEA Inferred from Electronic Annotation more info
involved_in membrane protein ectodomain proteolysis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of mRNA splicing, via spliceosome	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in regulation of alternative mRNA splicing, via spliceosome	IEA Inferred from Electronic Annotation more info
involved_in regulation of alternative mRNA splicing, via spliceosome	ISO Inferred from Sequence Orthology more info
involved_in regulation of postsynapse organization	ISO Inferred from Sequence Orthology more info
involved_in transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info
involved_in transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of catalytic step 2 spliceosome	IEA Inferred from Electronic Annotation more info
part_of catalytic step 2 spliceosome	ISO Inferred from Sequence Orthology more info
located_in euchromatin	IEA Inferred from Electronic Annotation more info
located_in euchromatin	ISO Inferred from Sequence Orthology more info
located_in extracellular exosome	IEA Inferred from Electronic Annotation more info
located_in extracellular exosome	ISO Inferred from Sequence Orthology more info
is_active_in glutamatergic synapse	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
is_active_in postsynaptic density	ISO Inferred from Sequence Orthology more info
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info
part_of spliceosomal complex	IBA Inferred from Biological aspect of Ancestor more info
part_of supraspliceosomal complex	IEA Inferred from Electronic Annotation more info
part_of supraspliceosomal complex	ISO Inferred from Sequence Orthology more info

General protein information

Go to the top of the page Help

Preferred Names: RNA-binding motif protein, X chromosome

Names: heterogeneous nuclear ribonucleoprotein G

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001166623.2 → NP_001160095.1 RNA-binding motif protein, X chromosome

See identical proteins and their annotated locations for NP_001160095.1

Status: VALIDATED

Description

Transcript Variant: This variant (3) uses a different splice site in the 5' UTR versus variant 1. Variants 1, 3, 4, and 5 all encode the same protein.

Source sequence(s)

AL672106

Consensus CDS

CCDS30153.1

UniProtKB/Swiss-Prot

Q8C2U6, Q9R0Y0, Q9WV02

UniProtKB/TrEMBL

A0A2I3BRL8

Related

ENSMUSP00000110374.2, ENSMUST00000114726.8

Conserved Domains (3) summary

PRK14086
Location:167 → 306

dnaA; chromosomal replication initiator protein DnaA

pfam08081
Location:173 → 217

RBM1CTR; RBM1CTR (NUC064) family

cd12382
Location:7 → 86

RRM_RBMX_like; RNA recognition motif (RRM) found in heterogeneous nuclear ribonucleoprotein G (hnRNP G), Y chromosome RNA recognition motif 1 (hRBMY), testis-specific heterogeneous nuclear ribonucleoprotein G-T (hnRNP G-T) and similar proteins
NM_001425953.1 → NP_001412882.1 RNA-binding motif protein, X chromosome

Status: VALIDATED

Source sequence(s)

AL672106

UniProtKB/Swiss-Prot

Q8C2U6, Q9R0Y0, Q9WV02
NM_001425954.1 → NP_001412883.1 RNA-binding motif protein, X chromosome

Status: VALIDATED

Source sequence(s)

AL672106

UniProtKB/Swiss-Prot

Q8C2U6, Q9R0Y0, Q9WV02
NM_011252.5 → NP_035382.1 RNA-binding motif protein, X chromosome

See identical proteins and their annotated locations for NP_035382.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) is the more frequently occurring transcript. Variants 1, 3, 4, and 5 all encode the same protein.

Source sequence(s)

AL672106

Consensus CDS

CCDS30153.1

UniProtKB/Swiss-Prot

Q8C2U6, Q9R0Y0, Q9WV02

UniProtKB/TrEMBL

A0A2I3BRL8

Related

ENSMUSP00000110378.2, ENSMUST00000114730.8

Conserved Domains (3) summary

PRK14086
Location:167 → 306

dnaA; chromosomal replication initiator protein DnaA

pfam08081
Location:173 → 217

RBM1CTR; RBM1CTR (NUC064) family

cd12382
Location:7 → 86

RRM_RBMX_like; RNA recognition motif (RRM) found in heterogeneous nuclear ribonucleoprotein G (hnRNP G), Y chromosome RNA recognition motif 1 (hRBMY), testis-specific heterogeneous nuclear ribonucleoprotein G-T (hnRNP G-T) and similar proteins

RNA

NR_029425.2 RNA Sequence

Status: VALIDATED

Description

Transcript Variant: This variant (2) has alternate 3' sequence, as compared to variant 1. The transcript is a nonsense-mediated mRNA decay (NMD) candidate, probably not making a protein.

Source sequence(s)

AL672106

Related

ENSMUST00000140384.8
NR_189635.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

AL672106
NR_189636.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

AL672106
NR_189637.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

AL672106
NR_189638.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

AL672106

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000086.8 Reference GRCm39 C57BL/6J

Range

56428708..56438405 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036161864.1 → XP_036017757.1 RNA-binding motif protein, X chromosome isoform X1

UniProtKB/Swiss-Prot

Q8C2U6, Q9R0Y0, Q9WV02

UniProtKB/TrEMBL

A0A2I3BRL8

Conserved Domains (3) summary

PRK14086
Location:167 → 306

dnaA; chromosomal replication initiator protein DnaA

pfam08081
Location:173 → 217

RBM1CTR; RBM1CTR (NUC064) family

cd12382
Location:7 → 86

RRM_RBMX_like; RNA recognition motif (RRM) found in heterogeneous nuclear ribonucleoprotein G (hnRNP G), Y chromosome RNA recognition motif 1 (hRBMY), testis-specific heterogeneous nuclear ribonucleoprotein G-T (hnRNP G-T) and similar proteins
XM_036161865.1 → XP_036017758.1 RNA-binding motif protein, X chromosome isoform X1

UniProtKB/Swiss-Prot

Q8C2U6, Q9R0Y0, Q9WV02

UniProtKB/TrEMBL

A0A2I3BRL8

Conserved Domains (3) summary

PRK14086
Location:167 → 306

dnaA; chromosomal replication initiator protein DnaA

pfam08081
Location:173 → 217

RBM1CTR; RBM1CTR (NUC064) family

cd12382
Location:7 → 86

RRM_RBMX_like; RNA recognition motif (RRM) found in heterogeneous nuclear ribonucleoprotein G (hnRNP G), Y chromosome RNA recognition motif 1 (hRBMY), testis-specific heterogeneous nuclear ribonucleoprotein G-T (hnRNP G-T) and similar proteins