Rangap1 RAN GTPase activating protein 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Rangap1provided by MGI
Official Full Name: RAN GTPase activating protein 1provided by MGI
Primary source: MGI:MGI:103071
See related: Ensembl:ENSMUSG00000022391 AllianceGenome:MGI:103071
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Fug1; mKIAA1835
Summary: Predicted to enable GTPase activator activity; RNA binding activity; and enzyme binding activity. Involved in nuclear export. Located in perinuclear region of cytoplasm. Is expressed in several structures, including brain; genitourinary system; liver; lung; and primitive streak. Orthologous to human RANGAP1 (Ran GTPase activating protein 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in testis adult (RPKM 67.3), CNS E11.5 (RPKM 30.0) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 15 E1; 15 38.21 cM

Exon count:: 18

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	15	NC_000081.7 (81588449..81614120, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	15	NC_000081.6 (81704248..81730798, complement)

Chromosome 15 - NC_000081.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

RanGAP1 maintains chromosome stability in limb bud mesenchymal cells during bone development.
Title: RanGAP1 maintains chromosome stability in limb bud mesenchymal cells during bone development.
Loss of RanGAP1 drives chromosome instability and rapid tumorigenesis of osteosarcoma.
Title: Loss of RanGAP1 drives chromosome instability and rapid tumorigenesis of osteosarcoma.
T-cell receptor (TCR) signaling promotes the assembly of RanBP2/RanGAP1-SUMO1/Ubc9 nuclear pore subcomplex via PKC-theta-mediated phosphorylation of RanGAP1.
Title: T-cell receptor (TCR) signaling promotes the assembly of RanBP2/RanGAP1-SUMO1/Ubc9 nuclear pore subcomplex via PKC-θ-mediated phosphorylation of RanGAP1.
data suggest that remodeling of the RanGAP-mediated nuclear transport system plays a key role in cell cycle exit for terminal differentiation of cortical neurons
Title: Terminal differentiation of cortical neurons rapidly remodels RanGAP-mediated nuclear transport system.
nuclear localization of Ran was strongly increased in MYCBP2-deficient DRGs
Title: MYCBP2 Is a Guanosine Exchange Factor for Ran Protein and Determines Its Localization in Neurons of Dorsal Root Ganglia.
immune cell adaptor SLP-76 binds directly to SUMO-RanGAP1 of cytoplasmic fibrils of the nuclear pore complex, and this interaction is needed for optimal NFATc1 and NF-kappaB p65 nuclear entry in T cells
Title: The Immune Adaptor SLP-76 Binds to SUMO-RANGAP1 at Nuclear Pore Complex Filaments to Regulate Nuclear Import of Transcription Factors in T Cells.
Protection from isopeptidase-mediated deconjugation regulates paralog-selective sumoylation of RanGAP1.
Title: Protection from isopeptidase-mediated deconjugation regulates paralog-selective sumoylation of RanGAP1.
These data suggest a dual function of the Nup358-RanGAP1 complex as a coordinator of importin beta recycling and reformation of novel import complexes.
Title: The Nup358-RanGAP complex is required for efficient importin alpha/beta-dependent nuclear import.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Gene trapped (1) 1 citation
Targeted (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

NoName (e-PCR)
- UniSTS:225124

Rangap1 (e-PCR), detects polymorphism
- UniSTS:527514

RH126910 (e-PCR)
- UniSTS:209121

U08110 (e-PCR)
- UniSTS:160487

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables GTPase activator activity	IBA Inferred from Biological aspect of Ancestor more info
enables GTPase activator activity	IEA Inferred from Electronic Annotation more info
enables GTPase activator activity	ISO Inferred from Sequence Orthology more info
enables RNA binding	IEA Inferred from Electronic Annotation more info
enables RNA binding	ISO Inferred from Sequence Orthology more info
enables small GTPase binding	IBA Inferred from Biological aspect of Ancestor more info
enables small GTPase binding	IEA Inferred from Electronic Annotation more info
enables small GTPase binding	ISO Inferred from Sequence Orthology more info
enables ubiquitin protein ligase binding	IEA Inferred from Electronic Annotation more info
enables ubiquitin protein ligase binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in activation of GTPase activity	ISO Inferred from Sequence Orthology more info
involved_in cellular response to peptide hormone stimulus	ISO Inferred from Sequence Orthology more info
involved_in cellular response to vasopressin	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of protein export from nucleus	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of protein export from nucleus	ISO Inferred from Sequence Orthology more info
involved_in nuclear export	EXP Inferred from Experiment more info	PubMed
involved_in nuclear export	IBA Inferred from Biological aspect of Ancestor more info
involved_in nuclear export	ISO Inferred from Sequence Orthology more info
involved_in protein sumoylation	ISO Inferred from Sequence Orthology more info
involved_in response to axon injury	IEA Inferred from Electronic Annotation more info
involved_in signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of SUMO ligase complex	ISO Inferred from Sequence Orthology more info
located_in aggresome	IEA Inferred from Electronic Annotation more info
located_in aggresome	ISO Inferred from Sequence Orthology more info
located_in axon cytoplasm	IEA Inferred from Electronic Annotation more info
located_in axon cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasmic periphery of the nuclear pore complex	IEA Inferred from Electronic Annotation more info
located_in cytoplasmic periphery of the nuclear pore complex	ISO Inferred from Sequence Orthology more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in dendrite	IEA Inferred from Electronic Annotation more info
located_in dendrite	ISO Inferred from Sequence Orthology more info
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info
colocalizes_with kinetochore	ISO Inferred from Sequence Orthology more info
colocalizes_with kinetochore	ISS Inferred from Sequence or Structural Similarity more info
located_in mitotic spindle	IEA Inferred from Electronic Annotation more info
located_in mitotic spindle	ISO Inferred from Sequence Orthology more info
located_in nuclear envelope	ISO Inferred from Sequence Orthology more info
located_in nuclear membrane	IEA Inferred from Electronic Annotation more info
located_in nuclear membrane	ISO Inferred from Sequence Orthology more info
part_of nuclear pore	ISO Inferred from Sequence Orthology more info
part_of nuclear pore	NAS Non-traceable Author Statement more info	PubMed
part_of nuclear pore cytoplasmic filaments	IEA Inferred from Electronic Annotation more info
part_of nuclear pore cytoplasmic filaments	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
is_active_in perinuclear region of cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in perinuclear region of cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in perinuclear region of cytoplasm	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: ran GTPase-activating protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001146174.1 → NP_001139646.1 ran GTPase-activating protein 1 isoform 1

See identical proteins and their annotated locations for NP_001139646.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR and has multiple coding region differences, compared to variant 3. These differences cause translation initiation at a downstream AUG and result in an isoform (1) with a shorter N-terminus, compared to isoform 2.

Source sequence(s)

AK159525, BY287991, BY438103

Consensus CDS

CCDS27670.1

UniProtKB/Swiss-Prot

P46061, Q60801, Q6NZB5

UniProtKB/TrEMBL

Q91YS2

Related

ENSMUSP00000057771.6, ENSMUST00000052374.13

Conserved Domains (3) summary

cd00116
Location:21 → 358

LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

sd00033
Location:51 → 81

LRR_RI; leucine-rich repeat [structural motif]

pfam07834
Location:408 → 587

RanGAP1_C; RanGAP1 C-terminal domain
NM_001358622.1 → NP_001345551.1 ran GTPase-activating protein 1 isoform 2

Status: VALIDATED

Description

Transcript Variant: This variant (3) encodes the longer isoform (2).

Source sequence(s)

AC102262, AC158970

UniProtKB/TrEMBL

Q91YS2

Conserved Domains (3) summary

cd00116
Location:69 → 406

LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

sd00033
Location:99 → 129

LRR_RI; leucine-rich repeat [structural motif]

pfam07834
Location:456 → 635

RanGAP1_C; RanGAP1 C-terminal domain
NM_011241.4 → NP_035371.4 ran GTPase-activating protein 1 isoform 1

See identical proteins and their annotated locations for NP_035371.4

Status: VALIDATED

Description

Transcript Variant: This variant (1) differs in the 5' UTR and has multiple coding region differences, compared to variant 3. These differences cause translation initiation at a downstream AUG and result in an isoform (1) with a shorter N-terminus, compared to isoform 2.

Source sequence(s)

AK146670, AK159525, BY287991, BY438103

Consensus CDS

CCDS27670.1

UniProtKB/Swiss-Prot

P46061, Q60801, Q6NZB5

UniProtKB/TrEMBL

Q91YS2

Related

ENSMUSP00000126849.2, ENSMUST00000170134.9

Conserved Domains (3) summary

cd00116
Location:21 → 358

LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

sd00033
Location:51 → 81

LRR_RI; leucine-rich repeat [structural motif]

pfam07834
Location:408 → 587

RanGAP1_C; RanGAP1 C-terminal domain

RNA

NR_152441.1 RNA Sequence

Status: VALIDATED

Description

Transcript Variant: This variant (4) uses an alternate 5' and 3' exon structure, compared to variant 3. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 3, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).

Source sequence(s)

AC102262, AC158970